Effects of local and systemic budesonide on allergen-induced airway reactions in the pig

British Journal of Pharmacology

Volumn 118, Issue 4, 1996, Pages 989-997

  Fornhem, Cecilia ^a   Dahlbäck, Magnus ^b   Kumlin, Maria ^a   Lundberg, Jan M ^a   Alving, Kjell ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Allergy; Ascaris suum; Bronchial circulation; Budesonide; Cysteinyl leukotrienes; Histamine; Late airways obstruction; Sensitized minipigs

Indexed keywords

ALLERGEN; BUDESONIDE; CATECHOLAMINE; HISTAMINE; HISTAMINE DERIVATIVE; LEUKOTRIENE E4; PEPTIDOLEUKOTRIENE;

AIRWAY CONSTRICTION; ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTERIAL GAS; ARTICLE; ASCARIS SUUM; BLOOD PH; CATECHOLAMINE BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; DRUG TISSUE LEVEL; INHALATIONAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LUNG CIRCULATION; LUNG RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; URINE LEVEL; VASODILATATION;

EID: 0029767882     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15497.x     Document Type: Article

References (26)

1. ALVING, K., MATRAN, R., FORNHEM, C. & LUNDBERG, J.M. (1991a). Late phase bronchial and vascular responses to allergen in actively-sensitized pigs. Acta Physiol. Scand., 143, 137-138.
2. 2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. Acta Physiol. Scand., 143, 93-103.
3. BOOIJ-NOORD, H., ORIE, N.G.M. & DE VRIES, K. (1971). Immediate and late obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J. Allergy Clin. Immunol., 48, 344-354.
4. BRATTSAND, R., THALEN, A., ROEMPKE, K., KÄLLSTRÖM, L. & GRUVSTAD, E. (1982). Development of new glucocorticosteroids with a very high ratio between topical and systemic activities. Eur. J. Respir. Dis. Suppl., 122, 62-73.
5. BROGDEN, R.N. & MCTAVISH, D. (1992). Budesonide. An updated review of its pharmacological properties, and therapeutic efficacy in asthma and rhinitis. Drugs, 44, 375-407.
6. DAHLBÄCK, M., MATTSSON, H., PRYTZ, M., HJERTBERG, E., TUNEK, A., MILLER-LARSON, A. & BRATTSAND, R. (1994). Uptake of a glucocorlicoid, budesonide, in rat airways and lung after inhalation and intravenous infusion. Eur. Respir. J., 7, 381s.
7. DANDURAND, R.J., WANG, C.G., LABERGE, S., MARTIN, J.G. & EIDELMAN, D.H. (1994). In vitro allergic bronchoconstriction in the Brown Norway rat. Am. J. Respir. Crit. Care Med., 149, 1499-1505.
8. ERJEFÄLT, I. & PERSSON, C.G.A. (1986). Anti-asthma drugs attenuate inflammatory leakage of plasma into airway lumen. Acta Physiol. Scand., 128, 653-654.
9. FORNHEM, C., KUMLIN, M., LUNDBERG, J.M. & ALVING, K. (1995a). Allergen-induced late-phase airways obstruction in the pig: mediator release and eosinophil recruitment. Eur. Respir. J., 8, 1100-1109.
10. FORNHEM, C., LUNDBERG, J.M. & ALVING, K. (1995b). Allergen-induced late-phase airways obstruction in the pig: the role of endogenous cortisol. Eur. Respir. J., 8, 928-937.
11. FORNHEM, C., PETERSON, C.G.B., DAHLBÄCK, M., SCHEYNIUS, A. & ALVING, K. (1996). Granulocyte function in the airways of allergen-challenged pigs: Effects of inhaled and systemic budesonide. Clin. Exp. Allergy (in press).
12. HJEMDAHL, P. (1987). Catecholamine measurements in plasma by high-performance liquid chromatography with electrochemical detection. Methods Enzymol., 142, 521-534.
13. JOHANSSON, S.-A., ANDERSSON, K.-E., BRATTSAND, R., GRUVSTAD, E. & HEDNER, P. (1982). Topical and system glucocorticoid potencies of budesonide, beclomethasone dipropionate and prednisolone in man. Eur. J. Respir. Dis. Suppl., 122, 74-82.
14. MEAD, J. (1961). Mechanical properties of lungs. Physiol. Rev., 41, 281-330.
15. PAGGIARO, P.L., DENTE, F.L., MORELLI, M.C., BANCALARI, L., FRANCO, A.D., GIANNINI, D., VAGAGGINI, B., BACCI, E., FABBRI, L.M. & GIUNTINI, C. (1994). Postallergen inhaled budesonide reduces late asthmatic response and inhibits the associated increase of airway responsiveness to methacholine in asthmatics. Am. J. Respir. Crit. Care. Med., 149, 1447-1451.
16. 2: Apparent correlation with in vivo modulation of mediator release. Proc. Natl. Acad. Sci. U.S.A., 85, 2315-2319.
17. RYRFELDT, Å., ANDERSSON, P., EDSBÄCKER, S., TÖNNESSON, M., DAVIES, D. & PAUWELS, R. (1982). Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid. Eur. J. Respir. Dis. Suppl., 122, 86-95.
18. RYRFELDT, Å., PERSSON, G. & NILSSON, E. (1989). Pulmonary deposition of the potent glucocorticoid budesonide, evaluated in an isolated perfused rat lung model. Biochem. Pharmacol., 38, 17-22.
19. SASAKI, H., YANAI, M., SHIMURA, S., OKAYAMA, H., AIKAWA, T., SASAKI, T. & TAKISHIMA, T. (1987). Late asthmatic response to Ascaris antigen challenge in dogs treated with metyrapone. Am. Rev. Respir. Dis., 136, 1459-1465.
20. SCHLEIMER, R.P., DAVIDSON, D.A., LICHTENSTEIN, L.M. & ADKINSON, JR, N.F. (1986). Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. J. Immunol., 136, 3006-3011.
21. SOARES, M.F.M., MOTA, I. & MACEDO, M.S. (1992). Isolation of Ascaris suum components which suppress IgE antibody responses. Int. Arch. Allergy Immunol., 97, 37-43.
22. STEVENS, W.H.M., ADELROTH, E, WATTIE, J., WOOLLEY, M.J., ELLIS, R., DAHLBÄCK, M. & O'BYRNE, P. (1994). Effect of inhaled budesonide on ozone-induced airway hyperresponsiveness and bronchoalveolar lavage cells in dogs. J. Appl. Physiol., 77, 2578-2583.
23. TOOGOOD, J.H., FRANKISH, C.W., JENNINGS, B.H., BASKERVILLE, J.C., BORGA, O., LEFCOE, N.M. & JOHANSSON, S.-A. (1990). A study of the mechanism of the antiasthmatic action of inhaled budesonide. J. Allergy Clin. Immunol., 85, 872-880.
24. TURNER, D.J., MYRON, P. & MARTIN, J.G. (1994). The role of endogenous corticosterone in the late response to allergen challenge in the Brown Norway (BN) rat. Am. J. Respir. Crit. Care Med., 149, A531.
25. WOOLLEY, M.J., DENBURG, J.A., ELLIS, R., DAHLBÄCK, M. & O'BYRNE, P.M. (1994a). Allergen-induced changes in bone marrow progenitors and airway responsiveness in dogs and the effect of inhaled budesonide on these parameters. Am. J. Respir. Cell Mol. Biol., 11, 600-606.
26. WOOLLEY, M.J., WATTIE, J., ELLIS, R., LANE, C.G., STEVENS, W.H.M., WOOLLEY, K.L., DAHLBÄCK, M. & O'BYRNE. P.M. (1994b). Effect of an inhaled corticosteroid on airway eosinophils and allergen-induced airway hyperresponsiveness in dogs. J. Appl. Physiol., 77, 1303-1308.