Estrogen-induced cell transformation and DNA adduct formation in cultured syrian hamster embryo cells

Molecular Carcinogenesis

Volumn 16, Issue 3, 1996, Pages 149-156

  Hayashi, Nobuko ^a   Hasegawa, Koko ^a   Komine, Akiko ^a   Tanaka, Yuriko ^a   McLachlan, John A ^b   Barrett, J Carl ^b   Tsutsui, Takeki ^a  

^a NIPPON DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYESTRADIOL; 4 HYDROXYESTRADIOL; DIENESTROL; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; DNA ADDUCT; DNA DAMAGE; DNA DETERMINATION; EMBRYO; EMBRYO CELL; ESTROGEN ACTIVITY; NONHUMAN; PRIORITY JOURNAL; SYRIAN HAMSTER;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CRICETINAE; DIETHYLSTILBESTROL; DNA ADDUCTS; DNA DAMAGE; DNA, NEOPLASM; EMBRYO; ESTROGENS; MESOCRICETUS; TUMOR CELLS, CULTURED;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0029766576     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199607)16:3<149::AID-MC5>3.0.CO;2-C     Document Type: Article

References (59)

1. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 21, Sex Hormones II. IARC, Lyon, 1979.
2. Lillehaug JR, Djurhuus R. Effect of diethylstilbestrol on the transformable mouse embryo fibroblast C3H/10T1 /2C18 cells. Tumor promotion, cell growth, DNA synthesis, and ornithine decarboxylase. Carcinogenesis 3:797-799, 1982.
3. Schuppler J, Dammè J, Schulte-Hermann R. Assay of some endogenous and synthetic sex steroids for tumor-initiating activity in rat liver using the Solt-Farber system. Carcinogenesis 4:239-241, 1983.
4. Siegfried JM, Nelson KG, Martin JL, et al. Promotional effect of diethylstilbestrol on human endometrial stromal cells pretreated with a direct-acting carcinogen. Carcinogenesis 5:641-646, 1984.
5. Kirkman H. Estrogen-induced tumors of the kidney in the Syrian hamster. III. Growth characteristics in the Syrian hamster. Monogr Natl Cancer Inst 1:1-59, 1959.
6. McLachlan JA, Wong A, Degen GH, et al. Morphological and neoplastic transformation of Syrian hamster embryo fibroblasts by diethylstilbestrol and its analogs. Cancer Res 42:3040-3045, 1982.
7. Liehr JG. 2-Fluoroestradiol: Separation of estrogenicity from carcinogenicity. Mol Pharmacol 23:278-281, 1983.
8. Li JJ, Li SA, Klicka JK, et al. Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney. Cancer Res 43:5200-5204, 1983.
9. Li JJ, Li SA. Estrogen-induced tumorigenesis in hamsters: Roles for hormonal and carcinogenic activities. Arch Toxicol 55:110-118, 1984.
10. Martin CN, McDermid AC, Garner RC. Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells. Cancer Res 38:2621-2627, 1978.
11. +/- mouse lymphoma mutagen assay system. Mutat Res 59:61-108, 1979.
12. Rüdiger HW, Haenish F, Metzler M, et al. Metabolites of diethylstilbestrol induce sister chromatid exchange in human cultured fibroblasts. Nature 281:392-394, 1979.
13. Bishun N, Forster S, Valera N, et al. The clastogenic effects of diethylstilbestrol on ascitic tumor cell in vivo. Microbios Lett 13:27-31, 1980.
14. Ivett JL, Tice RR. Diethylstilbestrol-diphosphate induces chromosomal aberrations but not sister chromatid exchanges in murine bone marrow cells in vivo. Environ Mutagen 3:445-452, 1981.
15. Hill A, Wolff S. Increased induction of sister chromatid exchange by diethylstilbestrol in lymphocytes from pregnant and premenopausal women. Cancer Res 42:893-896, 1982.
16. Martin CN, McDermid AC. Testing of 42 coded compounds for their ability to induce unscheduled DNA repair synthesis in the HeLa cells. In: deSerres FJ, Ashby J (eds), Evaluation of Short-Term Tests for Carcinogens. Elsevier/North Holland, New York, 1982, pp. 533-537.
17. Robinson DE, Mitchell AD. Unscheduled DNA synthesis response to human fibroblast WI-38 cells to 20 coded chemicals. In: deSerres FJ, Ashby J (eds), Evaluation of Short-Term Tests for Carcinogens. Elsevier/North Holland, New York, 1982, pp. 517-527.
18. Buenaventura SK, Jacobson-Kram D, Dearfield KL, et al. Induction of sister chromatid exchange by diethylstilbestrol in metabolically competent hepatoma cell lines but not in fibroblasts. Cancer Res 44:3851-3855, 1984.
19. Tsutsui T, Degen GH, Schiffmann D, et al. Dependence on exogenous metabolic activation for induction of unscheduled DNA synthesis in Syrian hamster embryo cells by diethylstilbestrol and related compounds. Cancer Res 44:184-189, 1984.
20. Tsutsui T, Suzuki N, Maizumi H, et al. Alteration in diethylstilbestrol-induced mutagenicity and cell transformation by exogenous metabolic activation. Carcinogenesis 7:1415-1418, 1986.
21. Liehr JG, Avitts TA, Randerath E, et al. Estrogen-induced endogenous DNA adduction: Possible mechanism of hormonal cancer. Proc Natl Acad Sci USA 83:5301-5305, 1986.
22. Gladek A, Liehr JG. Mechanism of genotoxicity of diethylstilbestrol in vivo. J Biol Chem 264:16847-16852, 1989.
23. Liehr JG. Genotoxic effects of estrogens. Mutat Res 238:269-276, 1990.
24. Barrett JC, Wong A, McLachlan JA. Diethylstilbestrol induces neoplastic transformation without measurable gene mutation at two loci. Science 212:1402-1404, 1981.
25. Tsutsui T, Maizumi H, McLachlan JA, et al. Aneuploidy induction and cell transformation by diethylstilbestrol: A possible chromosomal mechanism in carcinogenesis. Cancer Res 43:3814-3821, 1983.
26. Oshimura M, Barrett JC. Chemically induced aneuploidy in mammalian cells: Mechanisms and biological significance in cancer. Environ Mutagen 8:129-159, 1986.
27. Tsutsui T, Suzuki N, Fukuda S, et al. 17β-Estradiol-induced cell transformation and aneuploidy of Syrian hamster embryo cells in culture. Carcinogenesis 8:1715-1719, 1987.
28. Glatt HR, Metzler M, Oesch F. Diethylstilbestrol and 11 derivatives: A mutagenicity study with Salmonella typhimurium. Mutat Res 67:113-121, 1974.
29. Drevon C, Piccoli C, Montesano R. Mutagenicity assays of estrogenic hormones in mammalian cells. Mutat Res 89:83-90, 1981.
30. Althaus FR, Lawrence SD, Sattler GL, et al. Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens. Cancer Res 42:3010-3015, 1982.
31. Kinsella AR. Elimination of metabolic co-operation and the induction of sister chromatid exchanges are not properties common to all promoting or co-carcinogenic agents. Carcinogenesis 3:499-503, 1982.
32. Barrett JC, McLachlan JA, Elmore E. Inability of diethylstilbestrol to induce 6-thioguanine-resistant mutants and to inhibit metabolic co-operation of V79 Chinese hamster cells. Mutat Res 107:427-432, 1983.
33. Satya-Prakash KL, Hsu TC, Wheeler WJ. Metaphase arrest, anaphase recovery and aneuploidy induction in cultured Chinese hamster cells following exposure to mitotic arrestants. Anticancer Res 4:351-356, 1984.
34. Sato Y, Murai T, Tsumuraya M, et al. Disruptive effect of diethylstilbestrol on microtubules. Gann 75:1046-1048, 1984.
35. Sharp DC, Parry JM. Diethylstilbestrol: The binding and effects of diethylstilbestrol upon the polymerisation and depolymerisation of purified microtubule protein in vitro. Carcinogenesis 6:865-872, 1985.
36. Tucker RW, Barrett JC. Decreased numbers of spindle and cytoplasmic microtubules in hamster embryo cells treated with a carcinogen, diethylstilbestrol. Cancer Res 46:2088-2095, 1986.
37. Tsutsui T, Suzuki N, Maizumi H, et al. Characterization of an unscheduled DNA synthesis assay with Syrian hamster embryo cells. Mutat Res 129:111-117, 1984.
38. Matsushima T, Sawamura M, Hara K, et al. A safe substitute for polychlorinated biphenyls as an inducer of metabolic activation system. In: deSerres FJ, Fouts JR, Bend JR, Philpot PM (eds), In Vitro Metabolic Activation in Mutagenesis Testing, Elsevier/North-Holland, Amsterdam, 1976, pp. 85-88.
39. Kuroki T, Malaveille C, Drevon C, et al. Critical importance of microsome concentration in mutagenesis assay with V79 Chinese hamster cells. Mutat Res 63:259-272, 1979.
40. Berwald Y, Sachs L. In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons. J Natl Cancer Inst 35:641-661, 1965.
41. Barrett JC, Ts'o POP. Evidence for the progressive nature of neoplastic transformation in vitro. Proc Natl Acad Sci USA 75:3761-3765, 1978.
42. Tsutsui T, Barrett JC, Ts'o POP. Morphological transformation, DNA damage, and chromosomal aberrations induced by a direct DNA perturbation of synchronized Syrian hamster embryo cells. Cancer Res 39:2356-2365, 1979.
43. Tsutsui T, Maizumi H, Barrett JC. Colcemid-induced neoplastic transformation and aneuploidy in Syrian hamster embryo cells. Carcinogenesis 5:89-93, 1984.
44. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis 7:1543-1551, 1986.
45. 32P-postlabeling analysis of non-radioactive aromatic carcinogen-DNA adducts. Carcinogenesis 3:1081-1092, 1982.
46. Haaf H, Metzler M. Covalent binding of diethylstilbestrol to microsomal protein in vitro correlates with the organotropism of its carcinogenicity. Carcinogenesis 6:659-660, 1985.
47. Epe B, Hegler J, Metzler M. Site-specific covalent binding of stilbene-type and steroidal estrogens to tubulin following metabolic activation in vitro. Carcinogenesis 8:1271-1275, 1987.
48. Epe B, Harttig U, Stopper H, et al. Covalent binding of reactive estrogen metabolites to microtubular protein as a possible mechanism of aneuploidy induction and neoplastic cell transformation. Environ Health Perspect 88:123-127, 1990.
49. Metzler M, Biochemical toxicology of diethylstilbestrol. In: Hodgson E, Bend JR, Philipot RM (eds), Reviews in Biochemical Toxicology Vol. 6, Elsevier Science Publishing Company Inc., New York, 1984, pp. 191-220.
50. Degen GH, Metzler M, Sivarajah KS. Co-oxidation of diethylstilbestrol and structural analogs by prostaglandin synthase. Carcinogenesis 7:137-142, 1986.
51. Ross D, Mehlhorn RJ, Modeus P, et al. Metabolism of diethylstilbestrol by horseradish peroxidase and prostaglandin-H synthase. J Biol Chem 260:16210-16214, 1985.
52. Epe B, Schiffmann D, Metzler M. Possible role of oxygen radicals in cell transformation by diethylstilbestrol and related compounds. Carcinogenesis 7:1329-1334, 1986.
53. Liehr JG, Ulubelen AA, Strobel HW. Cytochrome P-450-mediated redox cycling of estrogens. J Biol Chem 261:16865-16870, 1986.
54. Roy D, Liehr JG. Temporary decrease in renal quinone reductase activity induced by chronic administration of estradiol to male Syrian hamsters: Increased superoxide formation by redox cycling of estrogen. J Biol Chem 263:3646-3651, 1988.
55. Liehr JG, Roy D. Free radical generation by redox cycling of estrogens. Free Radical Biol Med 8:415-423, 1990.
56. Roseier JA, Van Peteghem CH. Peroxidative in vitro metabolism of diethylstilbestrol induces formation of 8-hydroxy-2′-deoxyguanosine. Carcinogenesis 10:405-406, 1989.
57. Roy D, Froyd RA, Liehr JG. Elevated 8-hydroxydeoxy-guanosine levels in DNA of diethylstilbestrol-treated Syrian hamsters: Covalent DNA damage by free radicals generated by redox cycling of diethylstilbestrol. Cancer Res 51:3882-3885, 1991.
58. 32P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds. Muta Res 250:135-144, 1991.
59. 32P-postlabeling of DNA adducts induced by a Fenton-type oxygen radical-generating system. Carcinogenesis 13:1127-1135, 1992.