Antitumor activity of phenothiazine-related compounds

Anticancer Research

Volumn 16, Issue 4 A, 1996, Pages 1915-1918

  Nagy, Sylvia ^a   Argyelan, George ^a   Molnár, Joseph ^a   Kawase, Masami ^b   Motohashi, Noboru ^c  

^a UNIVERSITY OF SZEGED   (Hungary)

^b JOSAI UNIVERSITY   (Japan)

^c MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Antitumor activity; HEp 2 tumor cells; Phenothiazines; TCID50

Indexed keywords

PHENOTHIAZINE DERIVATIVE; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG POTENCY; HEP 2 CELL; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CELL LINE; CELL SURVIVAL; HUMANS; PHENOTHIAZINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0029766160     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Molnár J, Taródi B, Gálfi M, Matkovics B and Motohashi N: In vitro antiproliferative effects of tricyclic psychopharmaceutical agents and synergism with some resistance modifiers. Anticancer Res 12: 273-280, 1992.
2. Molnár J, Sakagami H and Motohashi N: Diverse biological activities displayed by phenothiazines, benzo[a]phenothiazines and benz[c]acridines. Anticancer Res 13: 1019-1026, 1993.
3. Molnár J, Földeák, S, Nakamura MJ, Kaizer F and Gutmann F: The influence of charge transfer complex formation on the antibacterial activity of tricyclic drugs. Xenobiotica 21: 309-316, 1991.
4. Molnár J: The role of charge distribution of tricyclic compounds in the antibacterial, antiviral and antiplasmid effects. In: Eckert GM, Gutmann F and Keyzer H (eds) Electropharmacology. CRC press, 1990, pp 206-218.
5. Molnár J, Petöfi S, Kurihara T, Sakagami H and Motohashi N: Antiplasmid and carcinogenic molecular orbitals of benz[c]acridine and related compounds. Anticancer Res 13: 263-266, 1993.
6. Motohashi N, Sakagami H, Kamata K and Yamamoto T: Cytotoxicity and differentiation-inducing activity of phenothiazine and benzo[a]phenothiazine derivatives. Anticancer Res 11: 1933-1938, 1991.
7. Motohashi N: Phenothiazines and calmodulin. Anticancer Res 11: 1125-1164, 1991.
8. Cohen MH: Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-1-nitrosourea by chlorpromazine and caffein. J Natl Cancer Inst 51: 1323-1325, 1973.
9. Osieka R, Glatte P, Pannenbäcker R and Schmidt CG: Enhancement of semustine-induced cytotoxicity by chlorpromazine and coffeine in a human melanoma xenograft. Cancer Treat Rep 70(10): 1167-1171, 1986.
10. Motohashi N, Kawase M, Kurihara T, Hevér A, Nagy S, Tanaka M and Molnár J : Synthesis and antitumor activity of 1-[2-(chloroethyl)-3-(2-substituted-10H-phenothiazin-10-yl)alkyl-1-ureas as potential anticancer agents. Anticancer Res, in press.
11. Reed LJ and Muench MA: A simple method of estimating fifty percent end points. Amer J Hyg 27: 493-497, 1938.
12. Edwin HL: General principles underlying laboratory diagnosis of virus and rickettsial infections. In: Francis TJ ed, Diagnostic procedures for virus and rickettsial diseases. 2nd ed., Broadway, New York City, American Public Health Association, 1956, pp.1-51.