Cupric ion/ascorbate/hydrogen peroxide-induced DNA damage: DNA-bound copper ion primarily induces base modifications

Free Radical Biology and Medicine

Volumn 21, Issue 3, 1996, Pages 261-273

  Drouin, Regen ^a,e   Rodriguez, Henry ^b   Gao, Shu Wei ^a   Gebreyes, Zewdu ^a   O'Connor, Timothy R ^c   Holmquist, Gerald P ^a   Akman, Steven A ^b,d  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Dept of Med Oncol/Therapeut R ^*  (United States)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d WAKE FOREST BAPTIST HEALTH   (United States)

^e LAVAL UNIVERSITY   (Canada)

Author keywords

DNA strand breaks; Free radicals; Oxidized DNA bases; Reactive oxygen species; Transition metals

Indexed keywords

ASCORBIC ACID; BACTERIAL ENZYME; COPPER; DNA BASE; EDETIC ACID; GLYOXAL; HYDROGEN PEROXIDE;

ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA DEGRADATION; DNA STRAND BREAKAGE; ESCHERICHIA COLI; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; MALE; METAL BINDING; PRIORITY JOURNAL; SKIN FIBROBLAST;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0029764611     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/0891-5849(96)00037-8     Document Type: Article

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