Identification of a specific DNA region required for enhanced transcription of HER2/neu in the MDA-MB453 breast cancer cell line

DNA and Cell Biology

Volumn 15, Issue 9, 1996, Pages 749-757

  Miller, Susan J ^a,b   Xing, Xiangming ^a   Xi, Larry ^a,c   Hung, Mien Chie ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Energy BioSystems Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE;

ARTICLE; BREAST CANCER; CANCER CELL; GENE AMPLIFICATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; METHYLATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; RNA TRANSLATION;

EID: 0029763569     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1996.15.749     Document Type: Article

References (17)

1. AUSUBEL, F.M., BRENT, R., KINGSTON, R.E., MOORE, D.D., SEIDMAN, J.G., SMITH, J.A., and STRUHL, K. (1989). Current Protocols in Molecular Biology. (Wiley-Interscience, New York, NY).
2. BARGMANN, C.I., and WEINBERG, R.A. (1988). Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion. EMBO J. 7, 2043-2052.
3. BARGMANN, C.I., HUNG, M.-C., and WEINBERG, R.A. (1986a). Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 45, 649-657.
4. BARGMANN, C.I., HUNG, M.-C., and WEINBERG, R.A. (1986b). The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature 319, 226-230.
5. BERCHUCK, A., KAMEL, A., WHITAKER, R., KERNS, B., OLT, G., KINNEY, R., SOPER, J.T., DODGE, R., CLARKE-PEARSON, D.L., MARKS, P., MCKENZIE, S., YIN, S., and BAST, R.C., JR. (1990). Overexpression of HER2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res. 50, 4087-4091.
6. BERGER, M.S., LOCHER, G.W., SAURER, S., GULLICK, W.J., WATERFIELD, M.D., CORNER, B., and HYNES, N.B. (1988). Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading. Cancer Res. 48, 1238-1243.
7. BOSHER, J.M., WILLIAMS, T., and HURST, H.C. (1995). The developmentally regulated transcription factor AP-2 is involved in cerbB-2 overexpression in human mammary carcinoma. Proc. Natl. Acad. Sci. USA 92, 744-747.
8. BRANDT-RAUF, P.W., RACKOVSKY, S., and PINCUS, M.R. (1990). Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p 185 protein with its function. Proc. Natl. Acad. Sci. USA 87, 8660-8664.
9. COUSSENS, L., YANG-FENG, T.L., LIAO, Y.-C., CHEN, E., GRAY, A., McGRATH, J., SEEBURG, P.H., LIBERMANN, T.A., SCHLESSINGER, J., FRANCKE, U., LEVINSON, A., and ULLRICH, A. (1985). Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 230, 1132-1139.
10. DI FIORE, P.P., PIERCE, J.H., KRAUS, M.H., SEGATTO, O., KING, C.R., and AARONSON, S.A. (1987). erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science 237, 178-182.
11. GUERIN, M., BARROIS, M., TERRIER, M.J., SPIELMANN, M., and RIOU, G. (1988). Overexpression of either c-myc or c-erbB-2/neu proto-oncogenes in human breast carcinomas: correlation with poor prognosis. Oncogene Res. 3, 21-31.
12. HER2 causes transformation and tumorigenesis of NIH 3T3 cells. Proc. Natl. Acad. Sci. USA 84, 7159-7163.
13. neu expression in human lung carcinomas predicts shortened survival. Cancer Res. 50, 5184-5191.
14. KING, C.R., BORRELLO, I., PORTER, L., COMOGLIO, P., and SCHLESSINGER, J. (1989). Ligand-independent tyrosine phosphorylation of EGF receptor and the erbB-2/neu proto-oncogene product is induced by hyperosmotic shock. Oncogene 4, 13-18.
15. KING, C.R., KRAUS, M.H., and AARONSON, S.A. (1985). Amplification of a novel v-ereB-related gene in a human mammary carcinoma. Science 229, 974-976.
16. KRAUS, M.H., POPESCU, N.C., AMBAUGH, S.C., and KING, C.R. (1987). Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J. 6, 605-610.
17. LACROIX, H., IGLEHART, J.D., SKINNER, M.A., and KRAUS, M.H. (1989). Overexpression of erbB-2 or EGF receptor proteins present in early stage mammary carcinoma is detected simultaneously in matched primary tumors and regional metastases. Oncogene 4, 145-151.