메뉴 건너뛰기




Volumn 94, Issue 4, 1996, Pages 763-774

Computer simulation of systemic circulation and clot lysis dynamics during thrombolytic therapy that accounts for inner clot transport and reaction

Author keywords

fibrinolysis; hemodynamics; pharmacokinetics; plasminogen activators; thrombolysis

Indexed keywords

ALTEPLASE; ANTIPLASMIN; MACROGLOBULIN; PLASMINOGEN; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE;

EID: 0029763116     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.4.763     Document Type: Article
Times cited : (45)

References (60)
  • 1
    • 0025907705 scopus 로고
    • Dependence of blood clot lysis on the mode of transport of urokinase into the clot: A magnetic resonance imaging study in vitro
    • Blinc A, Planinsic G, Keber D, Jarh O, Lahajnar G, Zidansek A, Demsar F. Dependence of blood clot lysis on the mode of transport of urokinase into the clot: a magnetic resonance imaging study in vitro. Thromb Haemost. 1991;65:549-552.
    • (1991) Thromb Haemost , vol.65 , pp. 549-552
    • Blinc, A.1    Planinsic, G.2    Keber, D.3    Jarh, O.4    Lahajnar, G.5    Zidansek, A.6    Demsar, F.7
  • 2
    • 0026487245 scopus 로고
    • Lysing patterns of retracted blood clots with diffusion or bulk flow transport of plasma with urokinase into clots: A magnetic resonance imaging study in vitro
    • Blinc A, Keber D, Lahajnar G, Stegnar M, Zidansek A, Demsar F. Lysing patterns of retracted blood clots with diffusion or bulk flow transport of plasma with urokinase into clots: a magnetic resonance imaging study in vitro. Thromb Haemost. 1992;68:667-671.
    • (1992) Thromb Haemost , vol.68 , pp. 667-671
    • Blinc, A.1    Keber, D.2    Lahajnar, G.3    Stegnar, M.4    Zidansek, A.5    Demsar, F.6
  • 3
    • 0028270974 scopus 로고
    • Transport phenomena and clot dissolution therapy: An experimental investigation of diffusion-controlled and permeation-enhanced fibrinolysis
    • Wu JH, Siddiqui K, Diamond SL. Transport phenomena and clot dissolution therapy: an experimental investigation of diffusion-controlled and permeation-enhanced fibrinolysis. Thromb Haemost. 1994;72:105-112.
    • (1994) Thromb Haemost , vol.72 , pp. 105-112
    • Wu, J.H.1    Siddiqui, K.2    Diamond, S.L.3
  • 4
    • 0027141112 scopus 로고
    • Inner clot diffusion and permeation during fibrinolysis
    • Diamond SL, Anand S. Inner clot diffusion and permeation during fibrinolysis. Biophys J. 1993;65:2622-2643.
    • (1993) Biophys J , vol.65 , pp. 2622-2643
    • Diamond, S.L.1    Anand, S.2
  • 5
    • 0029056293 scopus 로고
    • Enzyme-mediated proteolysis of fibrous biopolymers: Dissolution front movement in fibrin and collagen under conditions of diffusive and convective transport
    • Anand S, Wu JH, Diamond SL. Enzyme-mediated proteolysis of fibrous biopolymers: dissolution front movement in fibrin and collagen under conditions of diffusive and convective transport. Biotech Bioeng. 1995;48:89-107.
    • (1995) Biotech Bioeng , vol.48 , pp. 89-107
    • Anand, S.1    Wu, J.H.2    Diamond, S.L.3
  • 6
    • 0028909160 scopus 로고
    • Thrombolytic therapy in cardiogenic shock: Effect of increased aortic pressure and rapid tPA administration
    • Garber PJ, Mathieson AL, Ducas J, Patton JN, Geddes JS, Prewitt RM. Thrombolytic therapy in cardiogenic shock: effect of increased aortic pressure and rapid tPA administration. Can J Cardiol. 1995;11:30-36.
    • (1995) Can J Cardiol , vol.11 , pp. 30-36
    • Garber, P.J.1    Mathieson, A.L.2    Ducas, J.3    Patton, J.N.4    Geddes, J.S.5    Prewitt, R.M.6
  • 7
    • 0027098105 scopus 로고
    • Marked systemic hypotension depresses coronary thrombolysis induced by intracoronary administration of recombinant tissue-type plasminogen activator
    • Prewitt RM, Gu S, Garber PJ, Ducas J. Marked systemic hypotension depresses coronary thrombolysis induced by intracoronary administration of recombinant tissue-type plasminogen activator. J Am Coll Cardiol. 1992;20:1626-1633.
    • (1992) J Am Coll Cardiol , vol.20 , pp. 1626-1633
    • Prewitt, R.M.1    Gu, S.2    Garber, P.J.3    Ducas, J.4
  • 8
    • 0028210501 scopus 로고
    • Intraaortic balloon counter-pulsation enhances coronary thrombolysis induced by intraveneous administration of a thrombolytic agent
    • Prewitt RM, Gu S, Schick U, Ducas J. Intraaortic balloon counter-pulsation enhances coronary thrombolysis induced by intraveneous administration of a thrombolytic agent. J Am Coll Cardiol. 1994;23:794-798.
    • (1994) J Am Coll Cardiol , vol.23 , pp. 794-798
    • Prewitt, R.M.1    Gu, S.2    Schick, U.3    Ducas, J.4
  • 9
    • 0007362658 scopus 로고
    • Myocardial infarction with and without acute coronary occlusion: A pathological study
    • Miller RD, Burchell HB, Edwards JE. Myocardial infarction with and without acute coronary occlusion: a pathological study. Arch Intern Med. 1951;88:597-611.
    • (1951) Arch Intern Med , vol.88 , pp. 597-611
    • Miller, R.D.1    Burchell, H.B.2    Edwards, J.E.3
  • 10
    • 0025881577 scopus 로고
    • The influence of transport parameters and enzyme kinetics of the fibrinolytic system thrombolysis: Mathematical modeling of two idealized cases
    • Zidansek A, Blinc A. The influence of transport parameters and enzyme kinetics of the fibrinolytic system thrombolysis: mathematical modeling of two idealized cases. Thromb Haemost. 1991;65:553-559.
    • (1991) Thromb Haemost , vol.65 , pp. 553-559
    • Zidansek, A.1    Blinc, A.2
  • 12
    • 0020472522 scopus 로고
    • Kinetics of the activation of plasminogen by human tissue plasminogen activator
    • Hoylaerts M, Rijken DC, Lijnen HR, Collen D. Kinetics of the activation of plasminogen by human tissue plasminogen activator. J Biol Chem. 1982;257:2912-2919.
    • (1982) J Biol Chem , vol.257 , pp. 2912-2919
    • Hoylaerts, M.1    Rijken, D.C.2    Lijnen, H.R.3    Collen, D.4
  • 13
    • 0024387115 scopus 로고
    • Single bolus injection of recombinant tissue-type plasminogen activator in acute myocardial infarction
    • Tebbe U, Tanswell P, Seifried E, Feuerer W, Scholz KH, Herrman KS. Single bolus injection of recombinant tissue-type plasminogen activator in acute myocardial infarction. Am J Cardiol. 1989;64:448-453.
    • (1989) Am J Cardiol , vol.64 , pp. 448-453
    • Tebbe, U.1    Tanswell, P.2    Seifried, E.3    Feuerer, W.4    Scholz, K.H.5    Herrman, K.S.6
  • 16
    • 0026699163 scopus 로고
    • Penetration of macromolecules into contracted blood clots
    • Matveyev MY, Domogatsky SP. Penetration of macromolecules into contracted blood clots. Biophys J. 1992;63:862-863.
    • (1992) Biophys J , vol.63 , pp. 862-863
    • Matveyev, M.Y.1    Domogatsky, S.P.2
  • 17
    • 0022613702 scopus 로고
    • Dispersion in flow through porous media: One-phase flow
    • Sahimi M, Hughes BD, Scriven LE, Davis HT. Dispersion in flow through porous media: one-phase flow. Chem Eng Sci. 1986;41:2103-2122.
    • (1986) Chem Eng Sci , vol.41 , pp. 2103-2122
    • Sahimi, M.1    Hughes, B.D.2    Scriven, L.E.3    Davis, H.T.4
  • 19
    • 85054218128 scopus 로고
    • Control of t-PA mediated fibrinolysis
    • Kluft C, ed. Boca Raton, Fla: CRC Press
    • Ranby M, Brandstrom A. Control of t-PA mediated fibrinolysis. In: Kluft C, ed. Tissue-Type Plasminogen Activator (t-PA). Boca Raton, Fla: CRC Press; 1988:211-224.
    • (1988) Tissue-Type Plasminogen Activator (T-PA) , pp. 211-224
    • Ranby, M.1    Brandstrom, A.2
  • 20
    • 0025770332 scopus 로고
    • A pilot study of the efficacy and safety of bolus administration of alteplase in acute myocardial infarction
    • Gemmill JD, Hogg KJ, MacIntyre PD, Booth N, Rae AP, Dunn FG, Hillis WS. A pilot study of the efficacy and safety of bolus administration of alteplase in acute myocardial infarction. Br Heart J. 1991;66:134-138.
    • (1991) Br Heart J , vol.66 , pp. 134-138
    • Gemmill, J.D.1    Hogg, K.J.2    MacIntyre, P.D.3    Booth, N.4    Rae, A.P.5    Dunn, F.G.6    Hillis, W.S.7
  • 21
    • 0023181333 scopus 로고
    • Thrombolysis in Myocardial Infarction (TIMI): Comparative studies of coronary reperfusion and systemic fibrinolysis with two forms of recombinant tissue-type plasminogen activator
    • Mueller HS, Rao AK, Forman SA, and the TIMI Investigators. Thrombolysis in Myocardial Infarction (TIMI): comparative studies of coronary reperfusion and systemic fibrinolysis with two forms of recombinant tissue-type plasminogen activator. J Am Coll Cardiol. 1987;10:479-490.
    • (1987) J Am Coll Cardiol , vol.10 , pp. 479-490
    • Mueller, H.S.1    Rao, A.K.2    Forman, S.A.3
  • 22
    • 0023122647 scopus 로고
    • A kinetic analysis of fibrinolysis during plasminogen activator therapy
    • Noe DA, Bell WR. A kinetic analysis of fibrinolysis during plasminogen activator therapy. Clin Pharm Ther. 1987;41:297-303.
    • (1987) Clin Pharm Ther , vol.41 , pp. 297-303
    • Noe, D.A.1    Bell, W.R.2
  • 23
    • 0022576043 scopus 로고
    • Analysis of coagulation and fibrinolysis during intravenous infusion of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction
    • Collen D, Bounameaux H, DeCock F, Lijnen HR, Verstraete M. Analysis of coagulation and fibrinolysis during intravenous infusion of recombinant human tissue-type plasminogen activator in patients with acute myocardial infarction. Circulation. 1986;73:511-518.
    • (1986) Circulation , vol.73 , pp. 511-518
    • Collen, D.1    Bounameaux, H.2    DeCock, F.3    Lijnen, H.R.4    Verstraete, M.5
  • 24
    • 0020596647 scopus 로고
    • The binding of human plasminogen to fibrin and fibrinogen
    • Lucas MA, Fretto LJ, McKee PA. The binding of human plasminogen to fibrin and fibrinogen. J Biol Chem. 1983;258:4249-4256.
    • (1983) J Biol Chem , vol.258 , pp. 4249-4256
    • Lucas, M.A.1    Fretto, L.J.2    McKee, P.A.3
  • 25
    • 0028793649 scopus 로고
    • Impedance of a fibrin clot in a cylindrical tube: Relation to clot permeability and viscoelasticity
    • Thurston GB, Henderson NM. Impedance of a fibrin clot in a cylindrical tube: relation to clot permeability and viscoelasticity. Biorheology. 1995;32:503-520.
    • (1995) Biorheology , vol.32 , pp. 503-520
    • Thurston, G.B.1    Henderson, N.M.2
  • 26
    • 0026533894 scopus 로고
    • The amount of plasminogen, tissue-type plasminogen activator, and plasminogen activator inhibitor type 1 in human thrombi and the relation to ex-vivo lysibility
    • Potter van Loon BJ, Rijken DC, Brommer EJP, van der Maas APC. The amount of plasminogen, tissue-type plasminogen activator, and plasminogen activator inhibitor type 1 in human thrombi and the relation to ex-vivo lysibility. Thromb Haemost. 1992;67:101-105.
    • (1992) Thromb Haemost , vol.67 , pp. 101-105
    • Potter van Loon, B.J.1    Rijken, D.C.2    Brommer, E.J.P.3    Van der Maas, A.P.C.4
  • 28
    • 0025810227 scopus 로고
    • Bolus, front-loaded, and accelerated thrombolytic infusions for myocardial infarction and pulmonary embolism
    • Le vine MN. Bolus, front-loaded, and accelerated thrombolytic infusions for myocardial infarction and pulmonary embolism. Chest. 1991;99:128S-134S.
    • (1991) Chest , vol.99
    • Le Vine, M.N.1
  • 30
    • 85035173184 scopus 로고
    • Simulations of systemic circulation dynamics and consequent thrombi dissolution rates during intravenous thrombolytic therapy
    • November 13, Abstract
    • Anand S, Diamond SL. Simulations of systemic circulation dynamics and consequent thrombi dissolution rates during intravenous thrombolytic therapy. American Institute of Chemical Engineering 1995 Annual Meeting, November 13, 1995, 478. Abstract.
    • (1995) American Institute of Chemical Engineering 1995 Annual Meeting , pp. 478
    • Anand, S.1    Diamond, S.L.2
  • 33
    • 0027255041 scopus 로고
    • Thrombolytic therapy in patients where hypotension and cardiogenic shock complicate acute myocardial infarction
    • Prewitt RM. Thrombolytic therapy in patients where hypotension and cardiogenic shock complicate acute myocardial infarction. Can J Cardiol. 1993;9:155-157.
    • (1993) Can J Cardiol , vol.9 , pp. 155-157
    • Prewitt, R.M.1
  • 35
    • 0026024215 scopus 로고
    • Effects of hydralazine and increased cardiac output on recombinant tissue plasminogen activator-induced thrombolysis in canine pulmonary embolism
    • Prewitt RM, Downes AM, Gu SA, Chan SM, Ducas J. Effects of hydralazine and increased cardiac output on recombinant tissue plasminogen activator-induced thrombolysis in canine pulmonary embolism. Chest. 1991;99:708-714.
    • (1991) Chest , vol.99 , pp. 708-714
    • Prewitt, R.M.1    Downes, A.M.2    Gu, S.A.3    Chan, S.M.4    Ducas, J.5
  • 36
    • 9544220830 scopus 로고
    • The effect of a moderate increase in a low coronary artery inflow pressure on coronary thrombolysis induced by intraveneous administration of recombinant tissue plasminogen activator
    • Abstract
    • Prewitt RM, Gu S, Schick U, Wiens A, Ducas J. The effect of a moderate increase in a low coronary artery inflow pressure on coronary thrombolysis induced by intraveneous administration of recombinant tissue plasminogen activator. Thromb Haemost. 1993;69:1353. Abstract.
    • (1993) Thromb Haemost , vol.69 , pp. 1353
    • Prewitt, R.M.1    Gu, S.2    Schick, U.3    Wiens, A.4    Ducas, J.5
  • 38
    • 0027286644 scopus 로고
    • Characterization of ultrasound-potentiated fibrinolysis in vitro
    • Blinc A, Francis CW, Trudnowski JL, Carstensen EL. Characterization of ultrasound-potentiated fibrinolysis in vitro. Blood. 1993;81:2636-2643.
    • (1993) Blood , vol.81 , pp. 2636-2643
    • Blinc, A.1    Francis, C.W.2    Trudnowski, J.L.3    Carstensen, E.L.4
  • 42
    • 0024371085 scopus 로고
    • Thrombolysis in unstable angina: Will the beneficial effects of thrombolytic therapy in myocardial infarction apply to patients with unstable angina?
    • Ambrose JA, Alexopoulos D. Thrombolysis in unstable angina: will the beneficial effects of thrombolytic therapy in myocardial infarction apply to patients with unstable angina? J Am Coll Cardiol. 1989;13:1661-1671.
    • (1989) J Am Coll Cardiol , vol.13 , pp. 1661-1671
    • Ambrose, J.A.1    Alexopoulos, D.2
  • 43
    • 0022471046 scopus 로고
    • Fiberoptic observation of thrombosis and thrombolysis in isolated human coronary arteries
    • Uchida Y, Masuo M, Tomaru T, Kato A, Sugimoto T. Fiberoptic observation of thrombosis and thrombolysis in isolated human coronary arteries. Am Heart J. 1986;112:691-696.
    • (1986) Am Heart J , vol.112 , pp. 691-696
    • Uchida, Y.1    Masuo, M.2    Tomaru, T.3    Kato, A.4    Sugimoto, T.5
  • 44
    • 0020380731 scopus 로고
    • Local low-dose thrombolytic therapy of peripheral arterial occlusions
    • Hess H, Ingrisch H, Mietaschk T, Rath H. Local low-dose thrombolytic therapy of peripheral arterial occlusions. N Engl J Med. 1982;307:1627-1636.
    • (1982) N Engl J Med , vol.307 , pp. 1627-1636
    • Hess, H.1    Ingrisch, H.2    Mietaschk, T.3    Rath, H.4
  • 45
    • 0021803131 scopus 로고
    • Thrombolysis of peripheral arterial and graft occlusion
    • McNamara TO, Fischer JR. Thrombolysis of peripheral arterial and graft occlusion. Am J Radiol. 1985;144:769-775.
    • (1985) Am J Radiol , vol.144 , pp. 769-775
    • McNamara, T.O.1    Fischer, J.R.2
  • 46
    • 0028263098 scopus 로고
    • Iliofemoral deep venous thrombosis: Aggressive therapy with catheter-directed thrombolysis
    • Semba CP, Dake MD. Iliofemoral deep venous thrombosis: aggressive therapy with catheter-directed thrombolysis. Radiology. 1994;191:487-494.
    • (1994) Radiology , vol.191 , pp. 487-494
    • Semba, C.P.1    Dake, M.D.2
  • 47
    • 0023000367 scopus 로고
    • Concentration of protein in fibrin fibers and fibrinogen polymers determined by refractive index matching
    • Voter WA, Lucaveche C, Erickson HP. Concentration of protein in fibrin fibers and fibrinogen polymers determined by refractive index matching. Biopolymers. 1986;25:2375-2384.
    • (1986) Biopolymers , vol.25 , pp. 2375-2384
    • Voter, W.A.1    Lucaveche, C.2    Erickson, H.P.3
  • 51
    • 0021749404 scopus 로고
    • Sequence of formation of molecular forms of plasminogen and plasmin-inhibitor complexes in plasma activated by urokinase or tissue-type plasminogen activator
    • Thorsen S, Mullertz S, Suenson E, Kok P. Sequence of formation of molecular forms of plasminogen and plasmin-inhibitor complexes in plasma activated by urokinase or tissue-type plasminogen activator. Eur J Biochem. 1984;223:179-187.
    • (1984) Eur J Biochem , vol.223 , pp. 179-187
    • Thorsen, S.1    Mullertz, S.2    Suenson, E.3    Kok, P.4
  • 52
    • 0024361838 scopus 로고
    • Differences between binding of one-chain and two-chain tissue plasminogen activators to noncross-linked and cross-linked fibrin clots
    • Husain SS, Hasan AAK, Budzynski AZ. Differences between binding of one-chain and two-chain tissue plasminogen activators to noncross-linked and cross-linked fibrin clots. Blood. 1989;74:999-1006.
    • (1989) Blood , vol.74 , pp. 999-1006
    • Husain, S.S.1    Hasan, A.A.K.2    Budzynski, A.Z.3
  • 53
    • 0021351054 scopus 로고
    • Kinetics of the activation of plasminogen by natural and recombinant tissue type plasminogen activator
    • Zamarron C, Lijnen HR, Collen D. Kinetics of the activation of plasminogen by natural and recombinant tissue type plasminogen activator. J Biol Chem. 1984;259:2080-2093.
    • (1984) J Biol Chem , vol.259 , pp. 2080-2093
    • Zamarron, C.1    Lijnen, H.R.2    Collen, D.3
  • 55
    • 0019752371 scopus 로고
    • Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates
    • Lottenberg R, Christensen U, Jackson CM, Coleman PL. Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates. Methods Enzymol. 1981;80:341-361.
    • (1981) Methods Enzymol , vol.80 , pp. 341-361
    • Lottenberg, R.1    Christensen, U.2    Jackson, C.M.3    Coleman, P.L.4
  • 56
    • 0028878752 scopus 로고
    • A fluorescence quench and dequench assay of fibrinogen polymerization, fibrinogenolysis, and fibrinolysis
    • Wu JH, Diamond SL. A fluorescence quench and dequench assay of fibrinogen polymerization, fibrinogenolysis, and fibrinolysis. Anal Biochem. 1995;224:83-91.
    • (1995) Anal Biochem , vol.224 , pp. 83-91
    • Wu, J.H.1    Diamond, S.L.2
  • 57
    • 0018101441 scopus 로고
    • On the kinetics of the reaction between human antiplasmin and plasmin
    • Wiman B, Collen D. On the kinetics of the reaction between human antiplasmin and plasmin. Eur J Biochem. 1978;84:573-578.
    • (1978) Eur J Biochem , vol.84 , pp. 573-578
    • Wiman, B.1    Collen, D.2
  • 59
    • 0025797042 scopus 로고
    • On the reversible interaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator and with urokinase-type plasminogen activator
    • Lijnen HR, Van Hoef B, Collen D. On the reversible interaction of plasminogen activator inhibitor-1 with tissue-type plasminogen activator and with urokinase-type plasminogen activator. J Biol Chem. 1991;266:4041-4044.
    • (1991) J Biol Chem , vol.266 , pp. 4041-4044
    • Lijnen, H.R.1    Van Hoef, B.2    Collen, D.3
  • 60
    • 0018774402 scopus 로고
    • On the specific interaction between the lysine-binding sites in plasmin and complementary sites in a2-antiplasmin and in fibrinogen
    • Wiman B, Lijnen HR, Collen D. On the specific interaction between the lysine-binding sites in plasmin and complementary sites in a2-antiplasmin and in fibrinogen. Biochim Biophys Acta. 1979;579:142-154.
    • (1979) Biochim Biophys Acta , vol.579 , pp. 142-154
    • Wiman, B.1    Lijnen, H.R.2    Collen, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.