Differences between the structure and activity of potentially antimycobacterial and antifungal compounds: 3-Aryl-2H-1,3-benzoxazine-2,4(3H)-diones. Comparison of the Topliss approach with regression analysis

Scientia Pharmaceutica

Volumn 64, Issue 3-4, 1996, Pages 701-707

  Waisser, K ^a   Hladuvkova J ^a   Kubicova L ^a   Klimesova V ^a   Buchta, V ^a   Odlerova Z ^b  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

Author keywords

antifungal activity; antimycobacterial activity; benzoxazine; QSAR; tuberculostatics

Indexed keywords

3 PHENYL 2H 1,3 BENZOXAZINE 2,4(3H) DIONE DERIVATIVE; ANTIFUNGAL AGENT; BENZOXAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; DRUG STRUCTURE; FUNGUS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM; NONHUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

EID: 0029762760     PISSN: 00368709     EISSN: 22180532     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Kubicová L., Waisser K. (1992), Česk. Farm. 41: 208.
2. Waisser K., Kubicová L., Klimešová V., Odlerová Ž. (1993), Collect. Czech. Commun. 58: 2977.
3. Waisser K., Kubicová L. (1993), Česk. Farm. 42: 218.
4. Waisser K., Jílek P., Buchta VI. (1994), Relationships between the chemical structure and antimycobacterial and antimycotic activity of substances, Proceedings of Hammett Day (Ed. Holík M.), Masaryk University, Brno, p. 65.
5. Waisser K. (1995), Folia Pharm. Univ. Carol. 19: 79.
6. Waisser K., Kuchař M., Tichý M. (1985), QSAR in Examples, Charles University, Prague, p. 88.
7. Hansch C., Leo A. (1995), Exploring QSAR, vol. 2, American Chemical Society, Washington.
8. Topliss J C. (1977), J. Med. Chem. 20: 463.