Evidence for a mechanism of demyelination by human JC virus: Negative transcriptional regulation of RNA and protein levels from myelin basic protein gene by large tumor antigen in human glioblastoma cells

Journal of Medical Virology

Volumn 49, Issue 3, 1996, Pages 205-211

  Devireddy, Laxminarayana R ^a   Kumar, Kotlo U ^a,b   Pater, Mary M ^a   Pater, Alan ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

brain; mRNA accumulation; neurotropism; progressive multifocal leukoencephalopathy; protein accumulation; transcriptional regulation

Indexed keywords

MESSENGER RNA; MYELIN BASIC PROTEIN; VIRUS LARGE T ANTIGEN;

ARTICLE; CONTROLLED STUDY; DEMYELINATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; JC VIRUS; PROMOTER REGION; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION; TUMOR CELL LINE;

JC VIRUS; MUS MUSCULUS; POLYOMAVIRUS;

EID: 0029762454     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-9071(199607)49:3<205::aid-jmv8>3.0.co;2-8     Document Type: Article

References (35)

1. Allinquant B, Staugaitis SM, D'Urso D, Colman DR (1991): The ectopic expression of myelin basic protein isoforms in shiverer oligodendrocytes: Implications for myelinogenesis. Journal of Cell Biology 113:393-403.
2. Åström K-E, Mancall EL, Richardson EP (1958): Progressive multifocal leukoencephalopathy: Hitherto unrecognized complication of chronic lymphatic leukaemia and Hodgkin's disease. Brain 81:93-111.
3. 0 gene expression: A mechanism for papovaviral T-antigen-mediated demyelination. Neuron 12: 627-637.
4. Brophy PJ, Boccaccio GL, Colman DR (1993): The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes. Trends in Neurosciences 16:515-521.
5. Chang CF, Tada H, Khalili K (1994): The role of a pentanucleotide repeat sequence, AGGGAAGGGA, in the regulation of JC virus DNA replication. Gene 148:309-314.
6. Chowdhury M, Taylor JP, Tada H, Rappaport J, Wong-Staal F, Amini S, Khalili K (1990): Regulation of the human neurotropic virus promoter by JCV-T-antigen and HIV-1 tat protein. Oncogene 5:1737-1742.
7. Demel RA, London Y, Geurts Van Kessel WSM, Vossenberg FGA, Van Deenen LLM (1973): The specific interaction of myelin basic protein with lipids at the air-water interface. Biochimica et Biophysica Acta 311:507-519.
8. Dyson N, Bernards R, Friend SH, Gooding LR, Hassel JA, Major EO, Pipas JM, Vandyke T, Harlow E (1990): Large T-antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. Journal of Virology 64:1353-1356.
9. Frisque RJ, White FA (1992): The molecular biology of JC virus, causative agent of progressive multifocal leukoencephalopathy. In Roos RP (ed): "Molecular Neurovirology." Totowa, NJ: Humana Press.
10. Gorman CM, Moffat LF, Howard BH (1982): Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Molecular and Cellular Biology 2:1044-1051.
11. Grass C, Wetzel E, Baack M, Mock U, Knippers R (1988): High affinity SV40 T-antigen binding sites in the human genome. Virology 167:349-360.
12. Haas S, Haque NS, Beggs AH, Khalili K, Knobler RL, Small JA (1994): Expression of the myelin basic protein gene in transgenic mice expressing human neurotropic virus, JCV, early protein. Virology 202:89-96.
13. Haggerty S, Walker D, Frisque RJ (1989): JC virus-simian virus 40 genomes containing heterologous regulatory signals and chimeric early regions: Identification of regions restricting transformation by JC virus. Journal of Virology 63:2180-2190.
14. Harlow E, Lane D (1988): Cell staining. In: "Antibodies: A Laboratory Manual." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp 359-420.
15. Jensen NA, Smith GM, Shine HD, Garvey JS, Hood L (1993): Distinct hypomyelinated phenotypes in MBP-SV40 large T transgenic mice. Journal of Neuroscience Research 34:257-264.
16. Johnson RT (1983): Evidence for polyomavirus in human neurological diseases. In Sever JL, Madden DL (eds): "Polyomaviruses and Human Neurological Diseases." New York: Alan R. Liss, pp 183-190.
17. Kumar KU, Pater A, Pater MM (1993): Human JC virus perfect palindromic nuclear factor-1 binding sequences important for glial cell-specific expression in differentiating embryonal carcinoma cells. Journal of Virology 67:572-576.
18. Lane DP, Simanis V, Bartsch R, Yewdell J, Gannan J, Mole S (1985): Cellular targets for SV40 large T-antigen. Proceedings of the Royal Society of London (B) 266:25-42.
19. London WT, Houff SA, Madden DL, Fuccillo DA, Gravell M, Wallen WC, Palmer AE, Sever JL, Padgett BL, Walker DL, ZuRhein GM, Ohashi T (1978): Brain tumors in owl monkeys inoculated with a human polyomavirus (JC virus). Science 201:1246-1249.
20. Major EO, Amemiya K, Tornatore C, Houff S, Berger J (1992): Pathogenesis and molecular biology of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clinical Microbiological Reviews 5:49-73.
21. Maniatis T, Fritsch EF, Sambrook J (1982): "Molecular Cloning: A Laboratory Manual." Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
22. Mitchell PJ, Wang C, Tjian R (1987): Positive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T-antigen. Cell 50:847-861.
23. Miura M, Tamura T-A, Aoyama A, Mikoshiba K (1989): The promoter elements of the mouse myelin basic protein gene function efficiently in NG108-15 neuronal/glial cells. Gene 75:31-38.
24. Nakshatri H, Pater A, Pater MM (1990): Activity and enhancer binding factors for JC virus regulatory elements in differentiating embryonal carcinoma cells. Virology 177:784-789.
25. Padgett BL, Rogers CM, Walker DL (1977): JC virus, a human polyomavirus associated with progressive multifocal leukoencephalopathy: Additional biological characteristics and antigenic relationships. Infection and Immunity 15:656-662.
26. Quinlivan EB, Norris M, Bouldin TW, Suzuki K, Meeker R, Smith MS, Hall C, Kenney S (1992): Subclinical central nervous system infection with JC virus in patients with AIDS. Journal of Infectious Diseases 166:80-85.
27. Roach A, Boylan K, Horvath S, Prusiner SB, Hood LE (1983): Characterization of cloned cDNA representing rat myelin basic protein: Absence of expression in brain of shiverer mutant mice. Cell 34:799-806.
28. Sima AAF, Finkelstein SD, McLachlan DR (1983): Multiple malignant astrocytomas in a patient with spontaneous progressive multifocal leukoencephalopathy. Annals of Neurology 14:183-188.
29. Small JA, Scangos GA, Cork L, Jay G, Khoury G (1986): The early region of human papovavirus JC induces dysmyelination in transgenic mice. Cell 46:13-18.
30. Tasset D, Tora L, Fromental C, Scheer E, Chambon P (1990): Distinct classes of transcriptase activating domains function by different mechanisms. Cell 62:1177-1187.
31. Tevethia SS, Epler M, Georgoff I, Teresky A, Marlow M, Levine AJ (1992): Antibody response to human papovavirus JC (JCV) and simian virus 40 (SV40) T antigens in SV40 T antigen-transgenic mice. Virology 190:459-464.
32. Tjian R (1978): The binding site of SV40 DNA for a T-antigen related protein. Cell 13:165-179.
33. Trapp BD, Small JA, Pulley M, Khoury G, Scangos GA (1988): Dysmyelination in transgenic mice containing JC virus early region. Annals of Neurology 23:38-48.
34. Ueno S, Foster L, Hifumi GT, Tennekoon GI, Campagnoni AT (1995): The simian virus 40 large T-antigen does not inhibit translation of the 14-kDa myelin basic protein mRNA in reticulocyte lysates or in transfected cells. Journal of Neurochemistry 64:928-931.
35. Verdi JM, Campagnoni AT (1990): Translational regulation by steroids. Identification of a steroid modulatory element in the 5′-untranslated region of the myelin basic protein messenger RNA. Journal of Biological Chemistry 265:20314-20320.