The challenges of recombinant adeno-associated virus manufacturing: Alternative use of adeno-associated virus plasmid/liposome complexes for gene therapy applications

Current Topics in Microbiology and Immunology

Volumn 218, Issue , 1996, Pages 51-59

  Lebkowski, J S ^a   Okarma, T B ^a   Philip, R ^a  

^a Applied Immune Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOSOME;

ADENO ASSOCIATED VIRUS; GENE THERAPY; GENE TRANSFER; NONHUMAN; PLASMID; PRIORITY JOURNAL; REVIEW; VIRUS RECOMBINANT;

ADENO-ASSOCIATED VIRUS;

EID: 0029762365     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-80207-2_4     Document Type: Review

References (11)

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3. Holscher C, Hoier M, Kleinschmidt JA, Zentgral H, Burkle A, Heilbronn R (1994) Cell lines inducibly expressing the adeno-associated virus (AAV) rep genes: requirements for productive replication of rep-negative AAV mutants. J Virol 68(11): 7169-7177
4. Lebkowski JS, McNally M, Okarma TB, Lerch LB (1988) Adeno-associated virus: a vector system for efficient introduction and integration of DNA into a variety of mammalian cell types. Mol Cell Biol 8: 3988-3996
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8. Rolling F, Samulski RJ (1995) AAV as a viral vector for human gene therapy. Generation of recombinant virus. Mol Biotechnol 3(1): 9-16
9. Sugden B, Marsh K, Yates J (1985) A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus. Mol Cell Biol 5: 410-413
10. Yang Q, Chen F, Trempe JB (1994) Characterization of cell lines that inducibly express the adeno-associated virus rep proteins. J Virol 68(8): 4847-4856
11. Yates JL, Warren N, Sugden B (1985) Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells. Nature 313: 812-815