Characterization of lipophosphoglycan from a ricin-resistant mutant of Leishmania major

Glycobiology

Volumn 6, Issue 4, 1996, Pages 387-397

  Opat, Andrew ^b   Ng, Ken ^b   Currie, Graeme ^b   Handman, Emanuela ^a   Bacic, Antony ^b  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Glycolipid; Glycosylation mutants; Leishmania major; Lipophosphoglycan

Indexed keywords

GLYCOLIPID; LIPOPHOSPHOGLYCAN; RICIN;

ANIMAL EXPERIMENT; ARTICLE; GLYCOSYLATION; LEISHMANIA MAJOR; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; ARA; LEISHMANIA MAJOR; PROTOZOA;

EID: 0029761956     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/6.4.387     Document Type: Article

References (42)

1. Aebischer, T., Morris, L. and Handman, E. (1994) Intravenous injection of irradiated Leishmania major into susceptible BALB/c mice: immunisation or protective tolerance. Int. Immunol., 6, 1535-1543.
2. Alexander, J., and Russell, D G. (1992) The interaction of Leishmania species with macrophases. Adv. Parasitol., 31, 175-254.
3. Cappai, R., Morris, L., Aebischer, T., Bacic, A., Curtis, J.M., Kelleher, M., McLeod, K.S., Moody, S.F., Osborn, A.H. and Handman, E. (1994) Ricin-resistant mutants of Leishmania major which express modified lipophosphoglycan remain infective for mice. Parasitology, 108, 397-405.
4. Cenini, P., Bolognesi, A. and Stirpe, F. (1988) Ribosome-inactivating proteins from plants inhibit ribosome activity of Trypanosome and Leishmania. J. Protozool. 35, 384-387
5. Chaplain, M F. (1982) A rapid and sensitive method for the analysis of carbohydrate components in glycoproteins using gas-liquid chromatography. Anal. Biochem., 123, 336-341.
6. Ciucanu, I. and Kerek, F. (1984) A simple and rapid method for the permethylation of carbohydrates Carbohydr. Res., 131, 209-217.
7. Dell, A. and Thomas-Oates, J.E. (1989) Fast atom bombardment-mass spectrometry (FAB-MS), sample preparation and analytical stratagies. In: Biermann, C.J. and McGinnis, G.D. (eds). Analysis of Carbohydrates by GLC and MS. CRC Press, Boca Raton, FL, pp 217-235.
8. El-On, J., Bradley, D.J. and Freeman, J.C. (1980) Leishmania donovani: action of excreted factor on hydrolytic enzyme activity of macrophages from mice with genetically different resistance to infection. Exp. Parasitol., 49, 167-174.
9. Elhay, M., Kelleher, M., Bacic, A., McConville, M.J., Tolson, D.L., Pearson, T.W. and Handman, E. (1990) Lipophosphoglycan expression and virulence in ricin-resistant variants of Leishmania major. Mol. Biochem. Parasitol., 40, 255-267.
10. Ferguson, M.A.J. (1993) GPI membrane anchors: isolation and analysis. In: Fukuda, M. and Kobata, A. (eds). Glycobiology: A Practical Approach. IRL Press. Oxford, pp 349-382.
11. Ferguson, M.A.J., Homans, S.W., Dwek, R.A. and Rademacher, T.W. (1988) Glycosyl-phosphatidyl inositol moiety that anchors Trypanosoma brucei variant surface protein to the membrane Science, 239, 753-759.
12. Fox, J.D. and Robyt, J.F. (1991) Miniaturization of three carbohydrate analyses using a microsample plate reader Anal. Biochem., 195, 93-96.
13. Handman, E., Ceredig, R. and Mirehell, G.F. (1979) Marine cutaneous leishmaniasis; disease patterns in intact and nude mice of various genotypes and examination of some differences between normal and infected macrophages. Aust. J. Exp. Biol. Med. Sci., 57, 9-29.
14. Handman, E., Greenblat, C.L. and Watson, J.W. (1984) An amphipathic sulphated glycoconjugate of Leishmania major: characterisation with monoclonal antibodies EMBO J., 3, 2301-2306.
15. Handman, E., Schnur, L.F., Spithill, T.W. and Mitchell, G.F. (1986) Passive transfer of Leishmania lipophosphoglycan confers parasite survival in macrophages. J. Immunol., 137, 3608-3614.
16. Homans, S.W., Melhert, A. and Turco, S. (1992) Solution structure of the lipophosphoglycan of Leishmania donovani. Biochemistry, 31, 654-661.
17. Huang, C. and Turco, S.J. (1993) Defective galactofuranose addition in lipophosphoglycan biosynthesis in a mutant of Leishmania donovani. J. Biol. Chem., 268, 24060-24066.
18. Ilg, T., Stierhof, Y.-D., McConville, M.J. and Overath, P. (1995) Purification, partial characterisation and immunolocalisation of a proteophosphoglycan secreted by Leishmania mexicana amastigotes. Eur. J. Cell Biol., 66, 205-215.
19. Kelleher, M., Bacic, A. and Handman, E. (1992) Identification of a macrophage-binding determinant on lipophosphoglycan from Leishmania major promastigotes. Proc. Natl. Acad. Sci. USA, 89, 6-10.
20. Kelleher, M., Curtis, J.M., Sacks, D.L., Handman, E. and Bacic, A. (1994) Epitope mapping of monoclonal antibodies directed against lipophosphoglycan of Leishmania major promastigotes. Mol. Biochem. Parasitol. 66, 187-200.
21. Kelleher, M, Moody, S.F , Mirabile, P., Osborn, A.H., Bacic, A. and Handman, E. (1995) Lipophosphoglycan blocks attachment of Leishmania major amstigotes to macrophages. Infect. Immun., 63, 43-50.
22. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
23. McConville, M.J. and Bacic, A. (1989) A family of glycoinositol phospholipids from Leishmania major. J. Biol. Chem., 264, 757-766.
24. McConville, M.J. and Blackwell, J.M. (1991) Developmental changes in the glycosylated phosphatidylinositols of Leishmania donovani. Characterization of the promastigote and amastigote glycolipids J. Biol. Chem., 266, 15170-15179.
25. McConville, M.J. and Ferguson, M.A.J. (1993) The structure, biosynthesis and function of glycosylated-phosphatidylinositols in the parasitic protozoa and higher eukaryotes. Biochem. J., 294, 305-324.
26. McConville, M.J. and Homans, S.W. (1992) Identification of the defect in lipophosphoglycan biosynthesis in a non-pathogenic strain of Leishmania major. J. Biol. Chem., 267, 5855-5861.
27. McConville, M.J., Thomas-Oates, J.E., Ferguson, M.A.J and Homans, S.W. (1990) Structure of the lipophosphoglycan from Leishmania major. J. Biol. Chem., 265, 19611-19623.
28. McConville, M.J., Bacic, A., Mitchell, G.F and Handman, E. (1987) Lipophosphoglycan of Leishmania major that vaccinates against cutaneous leishmaniasis contains an alkylglycerophosphoinosityl lipid anchor. Proc Natl. Acad. Sci. USA, 84, 8941-8945.
29. McConville, M.J., Turco, S.J., Ferguson, M.A.J. and Sacks, D.L. (1992) Developmental modification of lipophosphoglycan during the differentiation of Leishmania major promastisotes to an infectious stage. EMBO J., 11, 3593-3600.
30. Mitchell, G.F , Curtis, J.M , Handman, E. and McKenzie, I.F.C. (1980) Cutaneous leishmaniasis in mice: disease patterns m reconstituted nude mice of several genotypes infected with Leishmania tropica. Aust. J. Exp. Biol. Med. Sci , 58, 521.
31. Moody, S.F., Handman, E., McConville, M.J. and Bacic, A. (1993) The structure of Leishmania major amastigote lipophosphoglycan. J. Biol. Chem., 268, 18457-18466
32. Pimenta, P.F., Saraiva, E.B.B. and Sacks, D.L. (1991) The comparative fine structure and surface glycoconjugate expression of three life stages of Leishmania major. Exp. Parasitol., 72, 191-204.
33. Pimenta, P.F.P., Turco, S.J., McConville, M.J., Lawyer, P.G., Perkins, P.V. and Sacks, D.L. (1992) Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. Science, 256, 1812-1815.
34. Puentes, S.M., Sacks, D.L., da Silva, R.P. and Joiner, K.A. (1988) Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan. J. Exp. Med., 167, 887-902.
35. Russell, D.G. and Wilheim, H. (1986) The involvement of the major surface glycoprotein (sp63) of Leishmania promastigotes in attachment to macrophages. J. Immunol., 136, 2613-2620.
36. Russell, D.G. and Wright, S.D. (1988) Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63. of Leishmania promastigotes. J. Exp. Med., 168, 279-292.
37. Ryan, K.A., Garraway, L.A., Descoteaux, A., Turco, S.J. and Beverley, S.M. (1993) Isolation of virulence genes directing surface glycosylphosphatidylinositol synthesis by functional complementation of Leishmania. Proc. Natl. Acad. Sci. USA, 90, 8609-8613.
38. Sacks, D. (1989) Metacyclogenesis in Leishmania promastigotes. Exp. Parasitol., 69, 100-103.
39. Shankar, A., Mitchen, T.K., Hall, L.R., Turco, S.J. and Titus, R.G. (1993) Reversion to virulence in Leishmania major correlates with expression of surface lipophosphoglycan. Mol. Biochem. Parasitol., 61, 207-216.
40. Thomas, J.R., McConville, M.J., Thomas-Oates, J., Homans, S.W., Ferguson-,M.A.J., Govin, P.A.J., Greis, K. and Turco, S.J. (1992) The refined structure of Leishmania donovani lipophosphoglycan. J. Biol. Chem., 267, 6829-6833.
41. Towbin, H., Staehelin, T. and Gordon, J. (1979) Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA, 76, 4350-4354.
42. Turco, S.J. and Descoteaux, A. (1992) The lipophosphoglycan of Leishmania parasites. Annu. Rev. Microbiol., 46, 65-94.