Electrophysiological changes of CA1 pyramidal neurons following transient forebrain ischemia: An in vivo intracellular recording and staining study

Journal of Neurophysiology

Volumn 76, Issue 3, 1996, Pages 1689-1697

  Xu, Z C ^a   Pulsinelli, W A ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIAL; FOREBRAIN; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; INTRACELLULAR RECORDING; MALE; MEMBRANE RESISTANCE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SPIKE; STAINING;

EID: 0029761570     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1996.76.3.1689     Document Type: Article

References (49)

1. BALESTRINO, M., AITKEN, P. G., AND SOMJEN, G. G. Spreading depression-like depolarization in CA1and fascia dentata of hippocampal slices: relationship to selective vulnerability. Brain Res. 497: 102-107, 1989.
2. BENVENISTE, H., DREJER, J., SCHOUSBOE, A., AND DIEMER, N. H. Elevation of the extracellular concentration of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374, 1984.
3. B receptor subtypes. Trends Neurosci. 11: 112-116, 1988.
4. BROWN, T. H., FRUCKE, R. A., AND PERKEL, D. H. Passive electrical constants in three classes of hippocampal neurons. J. Neurophysiol. 46: 812-827, 1981.
5. BUZSÁI, G., FREUND, T. F., BAYARDO, F., AND SOMOOYI, P. Ischemia-induced changes in the electrical activity of the hippocampus. Exp. Brain Res. 78: 268-278, 1989.
6. CHANG, H. S., SASAKI, T., AND KASSELL, N. F. Hippocampal unit activity after transient ischemia in rats. Stroke 20: 1051-1058, 1989.
7. CHERUBINI, E., BEN-ARI, Y., AND KRNJEVIC, K. Anoxia produces smaller changes in synaptic transmission, membrane potential, and input resistance in immature rat hippocampus. J. Neurophysiol. 62: 882-895, 1989.
8. CHOI, D. W. Ionic dependence of glutamate neurotoxicity in cortical cell culture. J. Neurosci. 7: 369-379, 1987.
9. CHOI, D. W. AND ROTHMAN, S. M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annu. Rev. Neurosci. 13: 171-182, 1990.
10. CONGAR, P., KHAZIPOV, R., AND BEN-ARI, Y. Direct demonstration of functional disconnection by anoxia of inhibitory interneurons from excitatory inputs in rat hippocampus. J. Neurophysiol. 73: 421-426, 1995.
11. 2 deprivation: in vitro intracellular studies. Am. J. Physiol. 262 (Lung Cell. Mol. Physiol. 6): L549-L554, 1992.
12. ECCLES, R. M., LØYNING, Y., AND OSHIMA, T. Effects of hypoxia on the monosynaptic reflex pathway in cat spinal cord. J. Neurophysiol. 29: 315-332, 1966.
13. FUJIWARA, N., HIGASHI, H., SHIMOJI, K., AND YOSHIMURA, M. Effects of hypoxia on rat hippocampal neurons in vitro. J. Physiol. Lond. 384: 131-151, 1987.
14. FURUKAWA, K., YAMANA, K., AND KOGURE, K. Postischemic alterations of spontaneous activities in rat hippocampal CA1 neurons. Brain Res. 530: 257-260, 1990.
15. GROSSMAN, R. G. AND WILLIAMS, V. F. Electrical activity and ultrastructure of cortical neurons and synapses in ischemia. In: Brain Hypoxia, edited by J. B. Brierley and B. S. Meldrum. London: Heinemann, 1971, p. 61-75.
16. HAGBERG, H., LEHMANN, A., SANDBERG, M., NYSTROM, B., AND JACOBSON, I. Ischemia-induced shift of inhibitory and excitatory amino acids from intra- to extracellular compartments. J. Cereb. Blood Flow Metab. 5: 413-419, 1985.
17. HANSEN, A. J., HOUNSGAARD, J., AND JAHNSEN, H. Anoxia increases potassium conductance in hippocampal nerve cells. Acta Physiol. Scand. 115: 301-310, 1982.
18. HERSHKOWITZ, N., KATCHMAN, A. N., AND VEREGGE, S. Site of synaptic depression during hypoxia: a patch-clamp analysis. J. Neurophysiol. 69: 432-441, 1993.
19. HORI, N., DOI, N., MIYAHARA, S., SHINODA, Y., AND CARPENTER, D. O. Appearance of NMDA receptors triggered by anoxia independent of voltage in vivo and in vitro. Exp. Neurol. 112: 304-311, 1991.
20. IMON, H., MITANI, A., ANDOU, Y., ARAI, T., AND KATAOKA, K. Delayed neuronal death is induced without postischemic hyperexcitability: continuous multiple-unit recording from ischemic CA1 neurons. J. Cereb. Blood Flow Metab. 11: 819-823, 1991.
21. JENSEN, M.S., LAMBERT, J. D. C., AND JOHANSEN, F. F. Electrophysiological recordings from rat hippocampus slices following in vivo brain ischemia. Brain Res. 554: 166-175, 1991.
22. 2 deprivation in the human and rat. J. Neurophysiol. 68: 2165-2173, 1992.
23. KATCHMAN, A. N., VICINI, S., AND HERSHKOWITZ, N. Mechanism of early anoxia-induced suppression of the GABAA-mediated inhibitory postsynaptic current. J. Neurophysiol. 71: 1128-1138, 1994.
24. KHAZIPOV, R., BREGESTOVSKI, P., AND BEN-ARI, Y. Hippocampal inhibitory interneurons are functionally disconnected from excitatory inputs by anoxia. J. Neurophysiol. 70: 2251-2259, 1993.
25. KIRINO, T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239: 57-69, 1982.
26. KIRINO, T., ROBINSON, H. P. C., MIWA, A., TAMURA, A., AND KAWAI, N. Disturbance of membrane function preceding ischemic delayed neuronal death in the gerbil hippocampus. J. Cereb. Blood Flow Metab. 12: 408-417, 1992.
27. KRNJEVIC, K. AND LEBLOND, J. Changes in membrane currents of hippocampal neurons evoked by brief anoxia. J. Neurophysiol. 62: 15-30, 1989.
28. KRNJEVIC, K., Xu, Y. Z., AND ZHANG, L. Anoxic block of GABAergic IPSPs. Neurochem. Res. 16: 279-284, 1991.
29. LEBLOND, J. AND KRNJEVIC, K. Hypoxic changes in hippocampal neurons. J. Neurophysiol. 62: 1-14, 1989.
30. LUHMANN, H. J. AND HEINEMANN, U. Hypoxia-induced functional alterations in adult rat neocortex. J. Neurophysiol. 67: 798-811, 1992.
31. MIYAZAKI, S., KATAYAMA, Y., FURUICHI, M., KINOSHITA, K., KAWAMATA, T., AND TSUBOKAWA, T. Post-ischemic potentiation of Schaffer collateral/ CA1 pyramidal cell responses of the rat hippocampus in vivo: involvement of N-methyl-D-aspartate receptors. Brain Res. 611: 155-159, 1993.
32. OLNEY, J. W., PRINCE, M. T., AND, SAMSON, L., AND LABRUYERE, J. The role of specific ions in glutamate neurotoxicity. Neurosci. Lett. 65: 65-71, 1986.
33. PULSINELLI, W. A. AND BRIERLEY, J. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10: 267-272, 1979.
34. PULSINELLI, W. A., BRIERLEY, J. B., AND PLUM, F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11: 491-498, 1982.
35. RICHTER, D. W., BISCHOFF, A., ANDERS, K., BELLINGHAM, M., AND WINDHORST, U. Response of the medullary respiratory network of the cat to hypoxia. J. Physiol. Lond. 443: 231-256, 1991.
36. ROSEN, A. S. AND MORRIS, M. E. Depolarizing effects of anoxia on pyramidal cells of rat neocortex. Neurosci. Lett. 124: 169-173, 1991.
37. ROSEN, A. S. AND MORRIS, M. E. Anoxic depression of excitatory and inhibitory postsynaptic potentials in rat neocortical slices. J. Neurophysiol. 69: 109-117, 1993.
38. ROTHMAN, S. M. Synaptic activity mediates death of hypoxic neurons. Science Wash. DC 220: 536-537, 1983.
39. ROTHMAN, S. M. Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death. J. Neurosci. 4: 1884-1891, 1984.
40. ROTHMAN, S. M. AND OLNEY, J. W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19: 105-111, 1986.
41. SCHMIDT-KASTNER, R. AND FREUND, T. F. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 40: 599-636, 1991.
42. SCHURR, A. AND RIGOR, B. M. The mechanism of cerebral hypoxic-ischemic damage. Hippocampus 2: 221-228, 1992.
43. 2+] in hypoxia and ischemia in rat brain in vivo. J. Gen. Physiol. 95: 837-866, 1990.
44. +] in the hippocampus during recovery from short-term, transient ischemia. J. Cereb. Blood Flow Metab. 12: 759-772, 1992.
45. SUZUKI, R., YAMAGUCHI, T., LI, C. L., AND KLATZO, I. The effects of 5-minute ischemia in mongolian gerbils. II. changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus. Acta Neuropathol. (Berl) 60: 217-222, 1983.
46. URBAN, L., NEILL, K. H., CRAIN, B. J., NADLER, J. V., AND SOMJEN, G. G. Postischemic synaptic physiology in area CA1 of the gerbil hippocampus studied in vitro. J. Neurosci. 9: 3966-3975, 1989.
47. XU, Z. C. Neurophysiological changes of spiny neurons in rat neostriatum after transient forebrain ischemia: an in vivo intracellular recording and staining study. Neuroscience 67: 823-836, 1995.
48. XU, Z. C. AND PULSINELLI, W. A. Responses of CA1 pyramidal neurons in rat hippocampus to transient forebrain ischemia: an in vivo intracellular recording study. Neurosci. Lett. 171: 187-191, 1994.
49. YOUNG, J. N. AND SOMJEN, G. G. Suppression of presynaptic calcium currents by hypoxia in hippocampal tissue slices. Brain Res. 573: 70-76, 1992.