Exploitation of hypoxia for radiation therapy: A lesson from phenothiazines

Medical Hypotheses

Volumn 47, Issue 2, 1996, Pages 107-110

  Kale, R K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

FERRIC ION; FERRITIN; FERROUS ION; PHENOTHIAZINE DERIVATIVE;

ANIMAL CELL; CANCER RADIOTHERAPY; CHEMOSENSITIVITY; DRUG MECHANISM; HYPOTHESIS; HYPOXIC CELL; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RADIATION PROTECTION; RADIOSENSITIZATION; REACTION ANALYSIS; SHORT SURVEY;

ANIMALIA;

EID: 0029761304     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-9877(96)90448-X     Document Type: Article

References (31)

1. Bergonie J, Tribondeau L. Interpretation of some results of radiotherapy and an attempt at determining a logical technique of treatment. Radiat Res 1959; 11: 587-588.
2. Thomlinson R H, Gray L H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9: 539-549.
3. Brown J M, Giaccia A J. Tumour hypoxia: the picture has changed in the 1990s. Int J Radiat Biol 1994; 65; 95-102.
4. von Sonntag G. The Chemical Basis of Radiation Biology. London: Taylor & Francis, 1987: 295-374.
5. Yuhas J M, Yurconic M, Kligerman M, West G, Peterson D F. Combined use of radioprotective and radiosensitizing drug in experimental radiotherapy. Radiat Res 1977; 70: 433-443.
6. Koch C J. Radiosensitization/protection: methods of analysis. Int J Radiat Biol 1985; 48: 651-659.
7. Sugahara T. Modification of radiosensitivity in the cancer treatment. New York: Academic Press, 1984.
8. Shenoy M A, Singh B B. Non-nitro radiation sensitizers. Int J Radiat Biol 1985; 48: 315-326.
9. Shenoy M A, Biaglow J W, Varnes M E, Daniel J W. A biochemical basis for the radiosensitizing and cytotoxic effects of chloropromazine hydrochloride in vitro and in vivo. Int J Radiat Oncol Biol Phys 1982; 8: 725-728.
10. Singh B B. Radiation sensitizers for tumour therapy. In: Jain V, Goel O, Pohlit W, eds. Recent advances in radiation oncology. New Delhi: Indian Council of Medical Research, 1990: 67-77.
11. George K C, Singh B B. Hyperthermic response of a mouse fibrosarcome as modified by phenothiazine drugs. Br J Cancer 1985; 51: 737-738.
12. George K C, Singh B B. Trimeprazine modified chemotherapeutic and hyperthermic response of a fibrosarcoma. Indian J Exper Biol 1988; 26: 341-344.
13. Shenoy M A, George K C, Singh B B, Gopal-Ayengar A R. Modification of radiation effect in single-cell systems by membrane binding agents. Int J Radiat Biol 1975; 28: 519-526.
14. Maniar H S, Singh B B. Modification of radiation response of E. coli B/r cells by phenothiazines. Int J Radiat Biol 1983; 44: 399-404.
15. Maniar H S, Nair C K K, Singh B B. Radioprotection of euoxic bacteria by phenothiazine drugs. Radiat Environ Biophys 1984; 23: 279-285.
16. Yonei S, Mitsutani C Y, Todo T, Niwa O. Modification of radiosensitivity of bacteria and mammalian cells by membrane-specific drugs. In: Sugahara T, ed. Modification of radiosensitivity in cancer treatment. New York: Academic Press, 1984: 291-311.
17. Kale R K, Sitasawad S L. Modification of radiation induced lipid peroxidation by calmodulin antagonists. Indian J Exper Biol 1990; 28: 757-761.
18. Varshney R, Kale R K. Effect of calmodulin antagonists on radiation-induced lipid peroxidation in microsomes. Int J Radiat Biol 1990; 58: 733-743.
19. Song C W. Effect of local hyperthermia on blood flow and microenvironment. Cancer Res 1984; 44: 4721S-4730S.
20. Cohen C, Shulman G, Bydgeon L R. Immunohistological ferritin in testicular seminoma. Cancer 1984; 54: 2190-2194.
21. Bezkorovainy A. Biochemistry of nonheme iron in Man. I. Iron protein and cellular iron metabolism. Clin Physiol Biochem 1989; 7: 1-17.
22. Kale R K, Sitasawad S L. Radiation induced iron release from transferrin. In: Chapman J D, Dewey W C, Whitmore G F, eds. Radiation Research: A Twentieth-Century Perspective. New York: Academic Press, 1991: 204.
23. Sitasawad S L. Investigation into radiation-induced lipid peroxidation. PhD thesis, New Delhi: Jawaharlal Nehru University, 1992.
24. Thornalley P J. The glyoxalase system in health and disease. Mol Aspects Med 1993; 14: 287-371.
25. McLellan A C, Thornalley P J. Glyoxalase activity in human red blood cells fractionated by age. Mech Ageing Dev 1989; 48: 63-71.
26. Hooper N I, Tisadale M J, Thornalley P J. Modification of the glyoxalase system in human HL60 promyelocytic leukemia cells during differentiation to neutrophils in vitro. Biochem Biophys Acta 1988; 966: 362-369.
27. Sharma R, Kale R K. Effect of radiation on glyoxalase I and glyoxalase II activities in spleen and liver of mice. Int J Radiat Biol 1993; 63: 233-238.
28. Kale R K. Radiation induced lipid peroxidation and phenothiazines. In: Singh B B, Bhatacharjee D, eds. Biological Concepts in Radiotherapy. New Delhi: Narosa, 1995: 165-174.
29. Kale R K. Methylglyoxalase system: a biochemical indicator for radiation protection studies. In: Proceedings of Second Meeting on Role of Biological Radiation Protection. INMAS, Delhi, 1995; in press.
30. Sharma-Luthra R, Kale R K. Inhibition of radiation-induced changes of glyoxalase I activity in mouse spleen and liver by phenothiazines. Int J Radiat Biol 1995; 67:403-410.
31. O'Connell M J, Ward R J, Baum H, Peters T J. The role of iron in ferritin and hemosiderin-mediated lipid peroxidation in liposomes. Biochem J 1985; 229: 135-139.