Transcription, adipocyte differentiation and obesity;Transcription, differenciation adipocytaire et obesite

Medecine/Sciences

Volumn 12, Issue 8-9, 1996, Pages 885-890

  Martin, Geneviève ^a   Staels, Bart ^a   Guerre Millo, Michèle ^b   Auwerx, Johan ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; PEROXISOME PROLIFERATOR; TRANSCRIPTION FACTOR;

ADIPOCYTE; CELL DIFFERENTIATION; DIETARY INTAKE; HUMAN; OBESITY; PHARMACOLOGY; REVIEW; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

EID: 0029760727     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/845     Document Type: Review

References (53)

1. Seidell JC. Obesity in Europe: scaling an epidemic. Int J Obes 1995; 19: S1-4.
2. Martin LF, Hunter S, Lauve RM, O'Leary JP. Severe obesity; expensive to society, frustrating to treat, but important to confront. South Med J 1995; 88: 895-902.
3. Desvergne B, Wahli W. PPAR: a key nuclear factor in nutrient/gene interactions. In: Bauerle P, ed. Inducible gene expression, vol 1. Boston: Birkhauser, 1994: 142-76.
4. Schoonjans K, Staels B, Auwerx J. Role of the peroxisome proliferator activated receptor (PPAR) in mediating effects of fibrates and fatty acids on gene expression. J Lipid Res 1995; sous presse.
5. Gottlicher M, Widmark E, Li Q, Gustafsson JA. Fatty acids activate chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc Natl Acad Sci USA 1992; 89: 4653-7.
6. Keller H, Dreyer C, Medin J, Mahfoudi A, Ozato K, Wahli W. Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci USA 1993; 90: 2160-4.
7. Yu K, Bayona W, Kallen CB, Harding HP, Ravera CP, McMahon G, Brown M, Lazar MA. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 1995; 270: 23975-83.
8. Amri EZ, Bonino F, Ailhaud G, Abumrad NA, Grimaldi PA. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. J Biol Chem 1995; 270:2367-71.
9. Tontonoz P, Hu E, Graves RA, Budavari AI, Spiegelman BM. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 8: 1224-34.
10. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W. Differential expression of peroxisome proliferator-activated receptors: tissue distribution of PPARα, β and γ in the adult rat. Endocrinology 1996; 137: 354-66.
11. Zhu Y, Alvares K, Huang Q, Rao MS, Reddy JK. Cloning of a new member of the peroxisome proliferator activated receptor gene family from mouse liver. J Biol Chem 1993; 268: 26817-20.
12. Zhu Y, Qi C, Korenberg JR, Chen XN, Nova D, Rao MS, Reddy JK. Structural organization of mouse peroxisome proliferator activated receptor γ (mPPARγ) gene: alternative promoter use and different splicing yield two mPPARγ isoforms. Proc Natl Acad Sci USA 1995; 92: 7921-5.
13. Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor. Cell 1994; 79: 1147-56.
14. Hu E, Tontonoz P, Spiegelman BM. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARgamma and C/EBPalpha. Proc Natl Acad Sci USA 1995; 92: 9856-60.
15. Amri EZ, Bertrand B, Ailhaud G, Grimaldi P. Regulation of adipose cell differentiation. I. Fatty acids are inducers of the aP2 gene expression. J Lipid Res 1991; 32: 1449-56.
16. Tontonoz P, Hu E, Devine J, Beale EG, Spiegelman BM. PPARγ2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol Cell Biol 1995; 15: 351-7.
17. Amri EZ, Ailhaud G, Grimaldi P. Regulation of adipose cell differentiation. II. Kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone. J Lipid Res 1991; 32: 1457-63.
18. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 1995; 270: 12953-6.
19. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM. 15-Deoxy-Δ12,14 prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 1995; 83: 803-12.
20. Kliewer SA, Lenhard JM, Willson TM, Patel I, Morris DC, Lehmann JM. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation. Cell 1995; 83: 813-9.
21. Chawla A, Lazar MA. Peroxisome proliferator and retinoid signaling pathways co-regulate preadipocyte phenotype and survival. Proc Natl Acad Sci USA 1994; 91: 1786-90.
22. Gaillard D, Negrel R, Lagarde M, Ailhaud G. Requirement and role of arachidonic acid in the differentiation of pre-adipose cells. Biochem J 1989; 257: 389-97.
23. Ibrahimi A, Teboul L, Gaillard D, Amri EZ, Ailhaud G, Young P, Cawthorne MA, Grimaldi P. Evidence for a common mechanism of action for fatty acids and thiazolidinedione antidiabetic agents on gene expression in preadipose cells. Mol Pharmacol 1994; 46: 1070-6.
24. Johnson PF, Landschulz WH, Graves BJ, McKnight SL. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev 1987; 1: 133-46.
25. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 1991; 5: 1538-52.
26. Roman C, Platero JS, Shuman J, Calame K. Ig/EBP-1: a ubiquitously expressed immunoglobulin enhancer binding protein that is similar to C/EBP and heterodimerizes with C/EBP. Genes Dev 1990; 4: 1404-15.
27. Williams SC, Cantwell CA, Johnson PF. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev 1991; 5: 1553-67.
28. Darlington GJ, Wang N, Hanson RW. C/EBPα: a critical regulator of genes governing metabolic processes. Curr Op Genet Dev 1995; 5: 565-70.
29. Christy RJ, Yang VW, Ntambi JM, Geiman DE, Landschulz WH, Friedman AD, Nakabeppu Y, Kelly TJ, Lane MD. Differentiation-induced gene expression in 3T3-L1 pre-adipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes. Genes Dev 1989; 3: 1323-35.
30. Lin FT, Lane MD. Antisense CCAAT/enhancer binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 adipocytes. Genes Dev 1992; 6: 533-44.
31. Samuelson L, Stromberg K, Vikman K, Bjursell G, Enerback S. The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte differentiation. EMBO J 1995; 10: 3787-93.
32. Freytag SO, Geddes TJ. Reciprocal regulation of adipogenesis by Myc and C/EBPα. Science 1992; 256: 379-82.
33. Lin FT, Lane MD. CCAAT/enhancer binding protein a is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 1994; 91: 8757-61.
34. Wang N, Finegold MJ, Bradley A, Ou C, Abdelsayed SV, Wilde MD, Taylor LR, Wilson DR, Darlington GJ. Impaired energy homeostasis in C/EBPα knockout mice. Science 1995; 269: 1108-12.
35. Yeh WC, Cao Z, Classon M, McKnight S. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995; 9: 168-81.
36. Wu Z, Xie Y, Bucher NLR, Farmer SR. Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev 1995; 9: 2350-63.
37. Descombes P, Schibler U. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 1991; 57: 569-79.
38. Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-53.
39. Fornace AJ, Neibert DW, Hollander MC, Luethy JD, Papathanasiou M, Fragoli J, Holbrook NT. Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents. Mol Cell Biol 1989; 9: 4196-203
40. Batchvarova N, Wang XZ, Ron D. Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J 1995; 14: 4654-61.
41. Tontonoz P, Kim JB, Graves RA, Spiegelman BM. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol Cell Biol 1993; 13: 4753-9.
42. Wang X, Sato R, Brown MS, Hua X, Goldstein JL. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 1994; 77: 53-62.
43. Lovell-Badge R. Living with bad architecture. Nature 1995; 376: 725-6.
44. Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJW. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nature Genet 1995; 10: 436-43.
45. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcner JA, Weremowicz S, Morton CC, Chada K. Disruption of the architectural factor HMGI-C: DNA binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 1995; 82: 57-65.
46. Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 1995; 376: 771-4.
47. Auwerx J, Leroy P, Schoonjans K. Lipoprotein lipase: recent contributions from molecular biology. Crit Rev Clin Lab Sci 1992; 29: 243-68.
48. Enerback S, Ohlsson BG, Samuelson L, Bjursell G. Characterization of the human lipoprotein lipase (LPL) promotor; evidence of two cis-regulatory regions, LP-a and LP-b, of importance for the differentiation-linked induction of the LPL gene during adipogenesis. Mol Cell Boil 1992; 12: 4622-33.
49. Swick AG, Lane MD. Identification of a transcriptional repressor down-regulated during adipocyte differentiation. Proc Natl Acad Sci USA 1992; 89: 7895-9.
50. Yang VW, Christy RJ, Cook JS, Kelly TJ, Lane MD. Mechanism of regulation of the 422(aP2) gene by cAMP during preadipocyte differentiation. Proc Natl Acad Sci USA 1989; 86: 3629-33.
51. Ro HS, Roncari DAK. The C/EBP-binding region and adjacent sites regulate expression of the adipose P2 gene in human preadipocytes. Mol Cell Biol 1991; 11: 2303-6.
52. Platt KA, Min HY, Ross SR. Spiegelman BM. Obesity-linked regulation of the adipsin gene promoter in transgenic mice. Proc Natl Acad Sci USA 1989; 86: 7490-4.
53. Platt KA, Claffey KP, Wilkison WO, Spiegelman BM, Ross SR. Independent regulation of adipose tissue-specificity and obesity response of the adipsin promoter in transgenic mice. J Biol Chem 1994; 269: 28558-62.