Malignant conversion of human cells by antisense cDNA to a putative tumor suppressor gene

Carcinogenesis

Volumn 17, Issue 8, 1996, Pages 1751-1755

  Li, Dawei ^a   Yan, Hua ^a   Chen, Jucheng ^a   Casto, Bruce C ^a   Theil, Karl S ^a   Milo, George E ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; COMPLEMENTARY DNA; PROTEIN P53;

ARTICLE; CARCINOGENESIS; CARCINOGENICITY; CELL TRANSFORMATION; CHROMOSOME 7Q; CHROMOSOME ANALYSIS; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCATION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ONCOGENE H RAS; PHENOTYPE; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

EID: 0029760619     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.8.1751     Document Type: Article

References (12)

1. Milo, G.E., Shuler, C.F., Stoner, G. and Chen, J.-C. (1992) Conversion of premalignant human cells to tumorigenic cells by methylmethane sulfonate and methylnitronitrosoguanidine. Cell Biol. Toxicol., 8, 193-205.
2. Milo, G.E., Shuler, C., Kurian, P. et al. (1990) Nontumorigenic squamous cell carcinoma line converted to tumorigenicity with methyl methanesulfonate without activation of HRAS or MYC. Proc. Natl Acad. Sci. USA, 87, 1268-1272.
3. Li, D., Noyes, I., Shuler, C. and Milo, G.E. (1995) Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion. Proc. Natl Acad. Sci. USA, 92, 6409-6413.
4. Milo, G.E., Li, D., Casto, B.C., Theil, K.S., Shuler, C., Noyes, I. and Chen, J.-C. (1996) Malignant conversion of chemically-transformed normal human cells. Proc. Natl Acad. Sci. USA, in press.
5. n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. Proc. Natl Acad. Sci. USA, 91, 12155-12158.
6. Bieche, I., Champeme, M.H., Matifas, F., Hacene, K., Callahan, R. and Lidereau, R. (1992) Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet, 339, 139-143.
7. Takahashi, S., Shan, A.L., Ritland, S.R., Delacey, K.A., Bostwick, D.G., Lieber, M.M., Thibodeau, S.N. and Jenkins, R.B. (1995) Frequent loss of heterozygosity at 7q31.1 in primary prostate cancer is associated with tumor aggressiveness and progression. Cancer Res., 55, 4114-4119.
8. Zenklusen, J.C., Thompson, J.C., Troncoso, P., Kagan, J. and Conti, C.J. (1994) Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. Cancer Res., 54, 6370-6373.
9. Collard, J.G., van de Poll, M., Scheffer, A., Roos, E., Hopman, A.H., Guerts van Kessel, A.H. and van Dongen, J.J. (1987) Location of genes involved in invasion and metastasis on human chromosome 7. Cancer Res., 47, 6666-6670.
10. Pedersen, B. and Ellegaard, J. (1994) A factor encoded by 7q31 suppresses expansion of the 7q-clone and delays cytogenetic progression. Cancer Genet. Cytogenet., 78, 181-188.
11. Denhardt, D.T. (1992) Mechanism of action of antisense RNA. Sometime inhibition of transcription, processing, transport, or translation. Annls NY Acad. Sci., 660, 70-76.
12. Murphy, L.D., Herzog, C.E., Rudick, J.B., Fojo, A.T. and Bates, S.E. (1990) Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression. Biochemistry, 29, 10351-10356.