Hepatic conjugation/deconjugation cycling pathways. Computer simulations examining the effect of Michaelis-Menten parameters, enzyme distribution patterns, and a diffusional barrier on metabolite disposition

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 24, Issue 2, 1996, Pages 219-243

  Hansel, Steven B ^a,b   Morris, Marilyn E ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

Author keywords

conjugation deconjugation; diffusional barrier; enzyme distribution; futile cycling; p nitrophenol; reversible conjugation

Indexed keywords

NITROPHENOL;

ARTICLE; COMPUTER SIMULATION; DRUG CONJUGATION; DRUG DISPOSITION; DRUG GLUCURONIDATION; DRUG METABOLISM; ENZYME LOCALIZATION; HYDROLYSIS; MICHAELIS MENTEN KINETICS; PRIORITY JOURNAL;

EID: 0029760423     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02353490     Document Type: Article

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