Altered dermatan sulfate proteoglycan synthesis in fibroblast cultures established from skin of patients with systemic sclerosis

Journal of Rheumatology

Volumn 23, Issue 8, 1996, Pages 1398-1406

  Westergren Thorsson, Gunilla ^a   Cöster, Lars ^a   Åkesson, Anita ^a   Wollheim, Frank A ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Connective tissue; Proteoglycans; Scleroderma

Indexed keywords

DERMATAN SULFATE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROTEOGLYCAN SYNTHESIS; SYSTEMIC SCLEROSIS;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CELLS, CULTURED; CHROMATOGRAPHY, GEL; CONNECTIVE TISSUE; DERMATAN SULFATE; FEMALE; FIBROBLASTS; HUMANS; MALE; MIDDLE AGED; PROTEOCHONDROITIN SULFATES; PROTEOGLYCANS; RNA, MESSENGER; SCLERODERMA, SYSTEMIC;

EID: 0029758544     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Black CM: The aetiopathogenesis of systemic sclerosis. J Intern Med 1993;234:3-8.
2. LeRoy EC, Black C, Fleishmajer R, et al: Scleroderma (systemic sclerosis): Classification, subsets and pathogenesis. J Rheumatol 1985;15:202-5.
3. Jiminez SA, Feldman G, Bashley RI, Bienkowski R, Rosenblom J: Co-ordinate increase in the expression of type I and type III collagen genes in progressive systemic sclerosis fibroblasts. Biochem J 1986;237:837-43.
4. Scharfetter K, Lanhat-Buttgereit B, Krieg T: Localisation of collagen mRNA in normal and scleroderma skin by in-situ hybridisation. Eur J Clin Invest 1988;18:9-17.
5. Peltonen J, Kähäri L, Uitto J, Jimenez SA: Increased expression of type VI collagen genes in systemic sclerosis. Arthritis Rheum 1990;33:1829-35.
6. Rudnicka L, Varga J, Chritiano AM, Iozzo RV, Jimenez SA, Uitto J: Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. J Clin Invest 1994;93:1709-15.
7. Kähäri K, Multimäki P, Vuorio E: Elevated proα2(I)collagen mRNA levels in cultured scleroderma fibroblasts result from an increased transcription rate of the corresponding gene. FEBS Lett 1987;215:331-4.
8. Kikuchi K, Hartl CW, Smith EA, LeRoy EC, Trojanowska M: Direct demonstration of transcriptional activation of collagen gene expression in systemic sclerosis fibroblasts: Insensitivity to TGFß1 stimulation. Biochim Biophys Res Com 1992;187:45-50.
9. 2 integrins, intercellular adhesion molecule 1, and endothelial leucocyte adhesion molecule 1 in the skin of patients with systemic sclerosis of recent onset. Arthritis Rheum 1992;35:390.
10. Majewski S, Hunzelmann N, Schirren CG, Mauch C, Aumailley M, Krieg T: Increased adhesion of fibroblasts from patients with scleroderma to extracellular matrix components: In vitro modulation by IFN-γ but not to TGF-β. J Invest Dermatol 1992,98:86-91.
11. Ivarsson M, McWhirter A, Black CM, Rubin K: Impaired regulation of collagen pro-α1(I) mRNA and change in pattern of collagen-binding integrins on scleroderma fibroblasts. J Invest Dermatol 1993;101:216-21.
12. Cöster L: Structure and properties of dermatan sulphate proteoglycans. Biochem Soc Trans 1991;19:866-8.
13. Scott J, Orford C: Dermatan sulphate-rich proteoglycan associate with rat tail tendon collagen at the d-band in the gap region. Biochem J 1981;197:213-6.
14. Hedbom E, Heinegård D: Interactions of a 59kD connective tissue matrix protein with collagen I and collagen II. J Biol Chem 1989;264:6898-905.
15. Fisher L, Termine JD, Young MF: Deduced protein sequence of bone small proteoglycan I (Biglycan) shows homology with proteoglycan II (Decorin) and several non-connective tissue proteins in a variety of species. J Biol Chem 1989;264:4571-6.
16. Uitto J, Helin G, Helin P, Lorenzen I: Connective tissue in scleroderma. Acta Dermatovener 1971;51:401-6.
17. Fleischmajer R, Perlish J: Glycosaminoglycans in scleroderma and scleredema. J Invest Dermatol 1972,58:129-32.
18. Ishikawa H, Horiushi R: Initial change of glycosaminoglycans in systemic scleroderma. Dermatologica 1975;150:334-5.
19. Buckingham RB, Prince RK, Rodnan GP: Progressive systemic sclerosis (PSS, scleroderma) dermal fibroblasts synthesize increased amounts of glycosaminoglycan. J Lab Clin Med 1983;101:659-69.
20. Whiteside TL, Worrall JG, Prince RK, Buckingham RB, Rodnan GP: Soluble mediators from mononuclear cells increase the synthesis of glycosaminoglycan by dermal fibroblast cultures derived from normal subjects and progressive systemic sclerosis patients. Arthritis Rheum 1985;28:188-97.
21. Whiteside T, Ferrarini M, Hebda P, Buckingham RB: Heterogeneous synthetic phenotype of cloned scleroderma fibroblasts may be due to aberrant regulation in the synthesis of connective tissue. Arthritis Rheum 1988;31:1221-9.
22. Akimoto S, Hayashi H, Ishikawa H: Disaccharide analysis of the skin glycosaminoglycans in systemic sclerosis. Br J Dermatol 1992;126:29-34.
23. Bashey RI, Perlish JS, Nochumson S, Stephens RE, Fleischmajer R: Connective tissue synthesis by cultured scleroderma fibroblasts. Arthritis Rheum 1977;20:879-85.
24. Vuorio TK, Kähäri VM, Lehtonen A, Vuorio E: Fibroblast activation in scleroderma. Scand J Rheumatol 1984;13:229-37.
25. Vuorio T, Kähäri V-M, Black C, Vuorio E: Expression of osteonectin, decorin and transforming growth factor-β1 genes in fibroblasts cultured from patients with systemic sclerosis and morphea. J Rheumatol 1991;18:247-51.
26. Masi AT, Rodnan GP, Medsger TA: Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee: Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980;23:581-90.
27. Åkesson A, Wollheim FA: Organ manifestations in 100 patients with progressive systemic sclerosis. A comparison between the CREST syndrome and diffuse scleroderma. Br J Rheumatol 1989;28:281-6.
28. Cöster L, Carlstedt I, Malmström A, Särnstrand B: Biosynthesis and secretion of dermatan sulphate proteoglycans in cultures of human skin fibroblasts. Biochem J 1984;220:5575-82.
29. Westergren-Thorsson G, Särnstrand B, Fransson L-Å, Malmström A: TGF-β enhances the production of hyaluronan in human lung but not in skin fibroblasts. Exp Cell Res 1990;186:192-5.
30. Westergren-Thorsson G, Fransson L-Å, Särnstrand B, Malmström A: Transforming growth factor-β induces selective increase of proteoglycan production and changes in the copolymeric structure of dermatan sulphate in human skin fibroblasts. Eur J Biochem 1992;205:277-86.
31. Lindblom A, Carlstedt I, Fransson L-Å: Identification of the core proteins in proteoglycans synthesized by vascular endothelial cells. Biochem J 1989;261:145-53.
32. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1979;227:680-5.
33. Chamberlain JP: Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. Anal Biochem 1979;98:132-5.
34. Westergren-Thorsson G, Antonsson P, Malmström A, Heinegård D, Oldberg Å: The synthesis of a family of structurally related proteoglycans in fibroblasts is differently regulated by TGF-β. Matrix 1991;11:177-83.
35. Chomchynski P, Sacchi N: Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987;162:156-9.
36. Westergren-Thorsson G, Hernnäs J, Särnstrand B, Oldberg Å, Heinegård D, Malmström A: Altered expression of small proteoglycans, collagen and transforming growth factor-β in developing bleomycin-induced pulmonary fibrosis in rats. J Clin Invest 1993;92:632-1.
37. Cöster L, Fransson L-Å: Isolation and characterization of dermatan sulphate proteoglycans from bovine sclera. Biochem J 1981;193:143-53.
38. Dours-Zimmerman MT, Zimmerman DR: A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican. J Biol Chem 1994;52:32992-8.
39. Norling B, Glimelius B, Westermark B, Wasteson Å: A chondroitin sulphate proteoglycan from human cultured glial cells aggregates with hyaluronic acid. Biochem Biophys Res Commun 1978;84:914-21.
40. Cöster L, Fransson L-Å, Sheen J, Nieduszynski IA, Phelps CF: Self-association of dermatan sulphate proteoglycans from bovine sclera. Biochem J 1981;197:483-90.
41. Chandrasekaran L, Tanzer ML: Molecular cloning of chicken aggrecan. Biochem J 1992;288:903-10.
42. Rauch U, Karthikeyan L, Maurel P, Margolis RU, Margolis RK: Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. J Biol Chem 1992;267:19536-47.
43. Yamada H, Watanabe K, Shimonaka M, Yamaguchi Y: Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/ versican family. J Biol Chem 1994;269:10119-26.
44. Vogel KG, Paulsson M, Heinegård D: Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J 1984;223:587-97.
45. Hedbom E, Timpl R, Heinegård D: Selective binding of biglycan to collagen VI (thesis). Lund, Sweden: Lund University, 1993.
46. Perlish JS, Lemlich G, Fleischmajer R: Identification of collagen fibrils in scleroderma skin. J Invest Dermatol 1988;90:48-54.
47. Smith G, Robenek H, Harrach B, et al: Interaction of small dermatan sulfate proteoglycan from fibroblasts with fibronectin. J Cell Biol 1987;104:1683-91.
48. Bidanset DJ, LeBaron R, Rosenberg L, Murphy-Ullrich JE, Höök M: Regulation of cell substrate adhesion: Effects of small galactosaminoglycan-containing proteoglycans. J Cell Biol 1992;118:1523-31.
49. Klareskog L, Gustavsson R, Scheynius A, Hällgren R: Increased expression of platelet-derived growth factor type b receptors in the skin of patients with systemic sclerosis. Arthritis Rheum 1990;33:1534-41.
50. Claman HN, Giorni RC, Siebold JR: Endothelial and fibroblastic activation in scleroderma; the myth of the "uninvolved skin." Arthritis Rheum 1991;34:1495-501.
51. LeRoy EC, Mercurio S, Sherer GK: Replication and phenotypic expression of control and sclerodermal human fibroblasts: Responses to growth factors. Proc Nat Acad Sci USA 1982;79:1286-90.
52. Needleman BW, Ordonez JV, Taramelli D, Alms W, Gayer K, Choi J: In vitro identification of a subpopulation of fibroblasts that produces high levels of collagen in scleroderma patients. Arthritis Rheum 1990a;33:842-52.
53. Yao LY, Moody C, Schonherr E, Wight TN, Sandell LJ: Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry. Matrix Biol 1994;14:213-25.
54. Briggs D, Black CM, Welsh KI: Genetic factors in scleroderma. Rheum Dis Clin North Am 1990;16:31-51.