Vitamin E ameliorates adverse effects of endothelial injury in brain arterioles

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 2 40-2, 1996, Pages

  Rosenblum, William I ^a   Nelson, Guy H ^b   Bei, Robert A ^b   Brandt, Richard B ^b   Chan, Winnie ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

endothelium dependent dilation; laser Evans blue; platelet adhesion aggregation

Indexed keywords

ACETYLCHOLINE; ALPHA TOCOPHEROL; ENDOTHELIUM DERIVED RELAXING FACTOR; N(G) METHYLARGININE;

ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; BRAIN INJURY; BRAIN PROTECTION; CONTROLLED STUDY; ENDOTHELIUM INJURY; HELIUM NEON LASER; MALE; MOUSE; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0029758190     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.2.h637     Document Type: Article

References (26)

1. Baez, S. Recording of microvascular dimensions with an image-splitter television microscope. J. Appl. Physiol. 21: 299-301, 1966.
2. Buettner, G. R. The pecking order of free radicals and antioxidants: Lipid peroxidation, α-toeopherol and ascorbate. Arch. Biochem. Biophys. 300: 535-543, 1993.
3. Diplock, A. T. (Editor). Vitamin E. In: Fat Soluble Vitamins. Lancaster, PA: Technomic Publishing, 1985, p. 154-224.
4. Dyson, J. Precise measurement by image splitting. J. Opt. Soc. Am. 50: 754-757, 1960.
5. Elliott, K. A. C., and H. H. Jasper. Physiologic salt solutions for brain surgery. J. Neurosurg. 6: 140-152, 1949.
6. Honour, A. J., and J. R. A. Mitchell. Platelet clumping in injured vessels. Br. J. Exp. Pathol 45: 75-87, 1964.
7. Hubel, C. A., K. C. Griggs, and M. K. McLaughlin. Lipid peroxidation and altered vascular function in vitamin E-deficient rats. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1539-H1545, 1989.
8. Kayden, H. J., and R. Silber. The role of vitamin E deficiency in abnormal autohaemolysis and acanthocytosis. Trans. Assoc. Am. Physicians 28: 334-331, 1965.
9. Moncada, S., M. W. Radomski, and R. M. J. Palmer. Endothelium derived relaxing factor, identification as nitric oxide and role in the control of vascular tone and platelet function. Biochem. Pharmacol. 37: 2495-2501, 1988.
10. Nishimura, H., W. I. Rosenblum, G. H. Nelson, and S. Boynton. Agents that modify EDRF formation alter antiplatelet properties of brain arteriolar endothelium in vivo. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H15-H21, 1991.
11. Ringstead, A. A preliminary note on the appearance of paresis in adult rats suffering from chronic avitaminosis E. Biochem. J. 29: 788-795, 1935.
12. Rosenblum, W. I. Endothelial dependent relaxation demonstrated in vivo in cerebral arterioles. Stroke 17: 494-497, 1986.
13. Rosenblum, W. I. Endothelium derived relaxing factor in brain blood vessels is not nitric oxide. Stroke 23: 1527-1532, 1992.
14. Rosenblum, W. I., S. Murata, G. H. Nelson, P. K. Werner, R. Ranken, and R. C. Harman. Anti CD31 delays platelet adhesion/aggregation at sites of endothelial injury in mouse cerebral arterioles. Am. J. Pathol. 145: 33-36, 1994.
15. Rosenblum, W. I., and G. H. Nelson. Singlet oxygen scavengers affect laser-dye impairment of endothelium-dependent responses of brain arterioles. Am. J. Physiol. 270 (Heart Circ. Physiol. 39): H1258-H1263, 1996.
16. Rosenblum, W. I., G. H. Nelson, C. S. Cockrell, and E. F. Ellis. Some properties of mouse platelets. Thromb. Res. 30: 347-355, 1982.
17. Rosenblum, W. I., G. H. Nelson, and J. T. Povlishock. Laser induced endothelial damage inhibits endothelium dependent relaxation in the cerebral microcirculation of the mouse. Circ. Res. 60: 169-176, 1987.
18. Rosenblum, W. I., H. Nishimura, and G. H. Nelson. Endothelium-dependent L-Arg- and L-NMMA-sensitive mechanisms regulate tone of brain microvessels. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1396-H1401, 1990.
19. Rosenblum, W. I., T. Shimizu, and G. H. Nelson. Endothelium dependent effects of substance P and calcitonin gene related peptide on mouse pial arterioles. Stroke 24: 1043-1048, 1993.
20. Rosenblum, W. I., and B. W. Zweifach. Cerebral microcirculation in the mouse brain. Arch. Neurol. 9: 414-423, 1963.
21. Rubanyi, G. M., J. C. Romero, and P. M. Vanhoutte. Flow-induced release of endothelium-derived relaxing factor. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H1145-H1149, 1986.
22. Rubino, A., and G. Burnstock. Recovery after dietary vitamin E supplementation of impaired endothelial function in vitamin E deficient rats. Br. J. Pharmacol. 112: 515-518, 1994.
23. Said, S., W. I. Rosenblum, J. T. Povlishock, and G. H. Nelson. Correlations between morphological changes in platelet aggregation and underlying endothelial damage in cerebral microcirculation of mice. Stroke 24: 1968-1976, 1993.
24. 1 when endothelium is intact. Am. J. Physiol. 264 (Heart Circ. Physiol. 33): H665-H669, 1983.
25. Towfighi, J. Aspects of chronic vitamin E deficiency on the nervous system of the rat. Acta Neuropathol. 54: 261-267, 1981.
26. Urano, S., Y. Inomori, T. Sugawara, Y. Kato, M. Kitahara, Y. Hasegawa, M. Matsuo, and K. Mukai. Vitamin E: inhibition of retinal-induced hemolysis and membrane-stabilizing behavior. J. Biol. Chem. 267: 18365-18370, 1992.