Treatment of human fetuses and induction of immunological tolerance in humans by in utero transplantation of stem cells into fetal recipients

Acta Haematologica

Volumn 96, Issue 3, 1996, Pages 115-119

  Touraine, Jean Louis ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

Fetal stem cells; Human fetuses; Immunological tolerance; In utero transplantation

Indexed keywords

ABORTION; ARTICLE; BETA THALASSEMIA; CLINICAL ARTICLE; FEMALE; FETUS; FETUS SURGERY; HUMAN; IMMUNOLOGICAL TOLERANCE; MALE; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME;

BETA-THALASSEMIA; FEMALE; FETAL DISEASES; GRANULOMATOUS DISEASE, CHRONIC; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNE TOLERANCE; IMMUNOLOGIC DEFICIENCY SYNDROMES; LIVER; MALE; NIEMANN-PICK DISEASES; T-LYMPHOCYTES;

EID: 0029757661     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203741     Document Type: Article

References (15)

1. Uphoft DE: Preclusion of secondary phase of irradiation syndrome by inoculation of fetal hematopoietic tissue following total-body X-irradiation. J Natl Cancer Inst 1958,20:625-632.
2. Touraine JL: Bone marrow and fetal liver transplantation in immunodeficiencies and inborn errors of metabolism: Lack of significant restriction of T-cell function in long-term chimeras despite HLA-mismatch. Immunol Rev 1983;71:103-121.
3. Touraine JL, Roncarolo MG, Royo C, Touraine F: Fetal tissue transplantation, bone marrow transplantation and prospective gene therapy in severe immunodeficiencies and enzyme deficiencies. Thymus 1987;10:75-87.
4. Touraine JL, Raudrant D, Royo C, Rcbaud A, Roncarolo MG, Souillet G, Philippe N. Touraine F, Bctucl H: In utero transplantation of stem cells in the bare lymphocyte syndrome. Lancet 1989;1: 1382.
5. Touraine JL: Rationale and results of in utero transplants of stem cells in humans. Bone Mar-rowTransplant 1992; 10(suppl 1): 121-126.
6. Bacchetta R, Vandekerckhove BAE, Bigler M, Roncarolo MG: Human and mouse SCID models to study tolerance after HLA-mis-matched fetal stem cell transplantation. Exp Hematol 1992;20:722.
7. Spits H, Touraine JL, Yssel H, deVries J, Roncarolo MG: Presence of host-reactive and MHC restricted T cells in a transplanted severe combined immunodeficient (SCID) patient suggests a positive selection and absence of clonal deletion. Immunol Rev 1990; 116:101-116.
8. Royo C, Touraine JL, de Boutciller O: Ontogeny of T-lymphocyte differentiation in the human fetus: Acquisition of phenotype and functions. Thymus 1987;10:57-73.
9. Roncarolo MG, Touraine JL, Banchereau J: Cooperation between major histocompatibility complex mismatched mononuclear cells from a human chimera in the production of antigen-specific antibody. J Clin Invest 1986;77:673-680.
10. Touraine JL, Bétuel H, Souillet G, Jeune M: Combined immunodeficiency disease associated with absence of ccll-surfacc HLA A and B antigens. J Pediatr 1978;93:47-51.
11. Vandekerckhove BAE, Namikawa R, Bacchetta R, Roncarolo MG: Human hematopoietic cells and thymic epithelial cells induce tolerance via different mechanisms in the SCID-hu mouse thymus. J Exp Med 1992; 175:1033-1043.
12. Plotnieky H, Touraine JL: Cytotoxic T cells from a human chimera induce regression of Epstein-Barr virus-infected allogeneic host cells. Int Immunol 1993;5:1413-1420.
13. Roncarolo MG, Yssel H, Touraine JL, Bacchetta R, Gebuhrer L, de Vries J, Spits H: Antigen recognition by MHC-incompatible cells of a human mismatched chimera. J Exp Med 1988;67:2139-2152.
14. Roncarolo MG, Yssel H, Touraine JL, Bétuel H, de Vries J, Spits H: Autoreactive T cell clones specific for class I and class II HLA antigens isolated from a human chimera. J Exp Med 1988;167:1523-1534.
15. Touraine JL, Bétuel H: Immunodeficiency diseases and expression of HLA antigens. Hum Immunol 1981;2:147-153.