Direct observation of affinity reactions by reflected-mode operation of integrated optical grating coupler

Sensors and Actuators, B: Chemical

Volumn 30, Issue 1, 1996, Pages 55-59

  Brandenburg, A ^a   Polzius, R ^b,d   Bier, F ^b,c   Bilitewski, U ^b   Wagner, E ^a  

^a FRAUNHOFER INSTITUTE FOR PHYSICAL MEASUREMENT TECHNIQUES IPM   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF POTSDAM   (Germany)

^d TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Affinity reactions; Grating couplers; Integrated optics; Reflected mode operation

Indexed keywords

BIOCHEMISTRY; CALCULATIONS; CHEMICAL REACTIONS; DIFFRACTION GRATINGS; INTEGRATED OPTICS; OPTICAL VARIABLES MEASUREMENT; PROTEINS; REFRACTIVE INDEX;

AFFINITY REACTIONS; DETECTION LIMIT; GRATING COUPLERS; HUMAN IMMUNOGLOBULIN; INTEGRATED OPTICAL GRATING COUPLER; REFLECTED MODE OPERATION;

WAVEGUIDE COUPLERS;

EID: 0029756321     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/0925-4005(95)01747-J     Document Type: Article

References (10)

1. W. Lukosz and K. Tiefenthaler, Directional switching in planar waveguides effected by adsorption-desorption processes, 2nd ECIO, Florence 1983, IEE Conf. Pub. No. 227, London, 1983, p. 152.
2. P. Nellen, K. Tiefenthaler and W. Lukosz, Integrated optical input grating couplers as biochemical sensors, Sensors and Actuators, 15 (1988) 285-295.
3. W. Lukosz, D. Clerc, Ph.M. Nellen, Ch. Stamm and P. Weiss, Output grating couplers on planar optical waveguides as direct immunosensors, Biosensors Bioelectron., 6 (1991) 227-232.
4. F.F. Bier, R. Jockers and R.D. Schmid, Integrated optical immunosensors for s-triazine determination, regeneration, calibration and limitation, Analyst, in press.
5. R. Jockers, F.F. Bier and R.D. Schmid, Specific binding of photosynthetic reaction centres to herbicide-modified grating couplers, Anal. Chim. Acta, 280 (1993) 53-59.
6. R. Polzius, F.F. Bier, U. Bilitewski, V. Jäger and R.D. Schmid, Online monitoring of monoclonal antibodies in animal cell culture using a grating coupler, Biotechnol. Bioeng., 42 (1993) 1287-1292.
7. L. Björck and G. Kronvall, Purification and some properties of streptococcal protein G, a novel IgG-binding reagent, J. Immunol., 133 (1984) 969-974.
8. A. Brandenburg and A. Combert, Grating couplers as chemical sensors: a new optical configuration, Sensors and Actuators B, 17 (1993) 35-40.
9. K. Tiefenthaler and W. Lukosz, Sensitivity of grating couplers as integrated-optical chemical sensors, J. Opt. Soc. Am. B, 6 (1989) 209-220.
10. W. Lukosz, P. Nellen, C. Stamm and P. Weiss, Output grating couplers on planar waveguides as integrated optical chemical sensors, Sensors and Actuators, B1 (1990) 585-588.