Effect of Y-24180, a platelet-activating factor-receptor antagonist, on the antigen-induced airway microvascular leakage in guinea pigs

Japanese Journal of Pharmacology

Volumn 72, Issue 3, 1996, Pages 209-215

  Iwahisa, Yoshinori ^a   Yamaguchi, Shuji ^a   Kagoshima, Masahiko ^a   Terasawa, Michio ^a  

^a Yoshitomi Pharmaceutical Industries Ltd   (Japan)

Author keywords

Airway microvascular leakage; Antigen; Platelet activating factor receptor antagonist; Y 24180

Indexed keywords

ANTIGEN; APAFANT; BRADYKININ; EVANS BLUE; HISTAMINE; ISRAPAFANT; LEUKOTRIENE D4; OZAGREL; PRANLUKAST; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; GUINEA PIG; LUNG CAPILLARY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; TRACHEA;

EID: 0029753650     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.72.209     Document Type: Article

References (28)

1. Evans TW, Chung KF, Rogers DF and Barnes PJ: Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. J Appl Physiol 63, 479-484 (1987)
2. Sirois MG, Plante GE, Braquet P and Sirois P: Role of eicosanoids in PAF-induced increases of the vascular permeability in rat airways. Br J Pharmacol 101, 896-900 (1990)
3. Vargaftig BB, Lefort J, Chignard M and Benveniste J: Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. Eur J Pharmacol 65, 185-192 (1980)
4. Smith LJ, Rubin AH and Patterson R: Mechanism of platelet activating factor-induced bronchoconstriction in humans. Am Rev Respir Dis 137, 1015-1019 (1988)
5. Chung KF, Aizawa H, Leikauf GD, Ueki IF, Evans TW and Nadel JA: Airway hyperresponsiveness induced by platelet-activating factor: Role of thromboxane generation. J Pharmacol Exp Ther 236, 580-584 (1986)
6. Morooka S, Uchida M and Imanishi N: Platelet-activating factor (PAF) plays an important role in the immediate asthmatic response in guinea-pig by augmenting the response to histamine. Br J Pharmacol 105, 756-762 (1992)
7. Wardlaw AJ, Moqbel R, Cromwell O and Kay AB: Platelet-activating factor: A potent chemotactic and chemokinetic factor for human eosinophils. J Clin Invest 78, 1701-1706 (1986)
8. Henocq E and Vargftig BB: Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. Lancet ii, 1378-1379 (1986)
9. Chung KF and Barnes PJ: PAF antagonists their potential therapeutic role in asthma. Drugs 35, 93-103 (1988)
10. Page CP: The role of platelet activating factor in allergic respiratory disease. Br J Clin Pharmacol 30, 99S-106S (1990)
11. Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF and Dolovich J: Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol 68, 347-355 (1981)
12. Chung KF: Role of inflammation in the hyperreactivity of the airways in asthma. Thorax 41, 657-662 (1986)
13. Evans TW, Dent G, Rogers DF, Aursudkij B, Chung KF and Barnes PJ: Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. Br J Pharmacol 94, 164-168 (1988)
14. 4 and PAF receptor antagonists in decreasing antigen-induced airway microvascular leakage. Adv Prostaglandin Thromboxane Leukotriene Res 23, 271-273 (1995)
15. Takehara S, Mikashima H, Muramoto Y, Terasawa M, Setoguchi M and Tahara T: Pharmacological actions of Y24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. Prostaglandins 40, 571-583 (1990)
16. Terasawa M, Aratani H, Setoguchi M and Tahara T: Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor. Prostaglandins 40, 553-569 (1990)
17. Okamoto H, Iwahisa Y and Terasawa M: Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. Agents Actions 35, 149-158 (1992)
18. Inoue H, Aratani H, Takishima T, Kagoshima M, Iwahisa Y and Terasawa M: Effect of a potent PAF antagonist, Y-24180, on an allergen-induced late asthmatic response in guinea-pigs. J Lipid Med 5, 173-176 (1992)
19. Hozawa S, Haruta Y, Ishioka S and Yamakido M: Effects of a PAF antagonist, Y-24180 on bronchial hyperresponsiveness in patients with asthma. Am J Respir Crit Care Med 152, 1198-1202 (1995)
20. Casals-Stenzel J, Muacevic G and Weber KH: Pharmacological actions of WEB 2086, a new specific antagonist of platelet-activating factor. J Pharmacol Exp Ther 241, 974-981 (1987)
21. Naito J, Komatsu H, Ujiie A, Hamano S, Kubota T and Tsuboshima M: Effect of thromboxane synthetase inhibitors on aggregation of rabbit platelet. Eur J Pharmacol 91, 41-48 (1983)
22. Obata T, Nambu F, Kitagawa T, Terashima H, Toda M, Okegawa T and Kawasaki A: ONO-1078: An antagonist of Leukotrienes. Adv Prostaglandin Thromboxane Leukotriene Res 17, 540-543 (1987)
23. 2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness. Eur J Pharmacol 260, 201-209 (1994)
24. Harada M, Takeuchi M, Fukao T and Katagiri K: A simple method for the quantitative extraction of dye extravasated into the skin. J Pharm Pharmacol 23, 218-219 (1971)
25. Rogers DF, Dijk S and Barnes PJ: Bradykinin-induced plasma exudation in guinea-pig airways: involvement of platelet activating factor. Br J Pharmacol 101, 739-745 (1990)
26. Amorim CZ, Martins MA, Cordeiro RSB and Vargaftig BB: Differential inhibition by the PAF receptor antagonist, WEB 2170, of allergic inflammation in single sensitized and boosted mice. Eur J Pharmacol 211, 29-33 (1992)
27. Hui KP, Lövall J, Chung KF and Barnes PJ: Attenuation of inhaled allergen-induced airway microvascular leakage and airway obstruction in guinea pigs by a 5-lipoxygenase inhibitor (A-63162). Am Rev Respir Dis 143, 1015-1019 (1991)
28. Obata T, Kobayashi T, Okada Y, Nakagawa N, Terawaki T and Aishita H: Effect of a peptide leukotriene antagonist, ONO-1078 on antigen-induced airway microvascular leakage in actively sensitized guinea pigs. Life Sci 51, 1577-1583 (1992)