Regulation and repair of double-strand DNA breaks

Critical Reviews in Eukaryotic Gene Expression

Volumn 6, Issue 4, 1996, Pages 345-375

  Weaver, David T ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

DNA double strand break repair; DNA dependent protein kinase; ionizing radiation; Ku; V(D)J recombination

Indexed keywords

DNA POLYMERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN KINASE; PROTEIN P53;

DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; DNA STRAND BREAKAGE; DNA SYNTHESIS; ENZYME SUBUNIT; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TRANSCRIPTION REGULATION;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0029752779     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v6.i4.20     Document Type: Review

References (231)

1. Alvarez-Gonzalez R, Rodriguez-Pacheco G, Mendoza-Alvarez H (1994): Enzymology of ADP-ribose polymer synthesis. Mol Cell Biochem 138:33-37.
2. Anderson CW (1993): DNA damage and the DNA-activated protein kinase. TIBS 18:433-437.
3. Anderson CW, Lees-Miller SP (1992): The nuclear serine/threonine protein kinase DNA-PK. Crit Rev Euk Gene Exp 2:283-314.
4. Araki H, Hamatake RK, Johnston LH, Sugino A (1991): DPB2, the gene encoding DNA polymerase II subunit B is required for chromosomal replication in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 88.
5. Araki H, Ropp PA, Johnson AL, Johnston LH, Morrison A, Sugino A (1992): DNA polymerase II, the probable homolog of mammalian DNA polymerase ε, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. EMBO J 11.
6. Balalkin G, Yakovleva T, Selivanova G, Magnusson KP, Szekely L, Kiseleva E, Klein G, Terenius L, Wiman KG (1994): p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc Natl Acad Sci USA 91:413-417.
7. Banga S, Hall K, Sandhu A, Weaver D, Athwal R (1994): Complementation of V(D)J recombination defect and X-ray sensitivity of scid mouse cells by human chromosome 8. Mutat Res 315:239-247.
8. Bannister AJ, Gottlieb T, Kouzarides T, Jackson SP (1994): c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro; definition of the minimal kinase recognition motif. Nucl Acids Res 21:1289-1295.
9. Barnes, DE, Johnson LH, Kodama K-I, Tomkinson AE, Lasko DD, Lindahl T (1990): Human DNA ligase I cDNA: cloning and functional expression in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 87:6679-6683.
10. Barnes DE, Kodama K, Tynan K, Trask BJ, Christensen M, De JP, Spurr NK, Lindahl T, Mohrenweiser HW (1992): Assignment of the gene encoding DNA ligase I to human chromosome 19q13.2-13.3. Genomics 12:164-6.
11. Barnes DE, Tomkinson AE, Lehmann AR, Webster AD, Lindahl T (1992): Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents. Cell 69:495-503.
12. Beall EL, Admon A, Rio DC (1994): A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats. Proc Natl Acad Sci USA 91:12681-12685.
13. Biedermann KA, Sun J, Giaccia AJ, Tosto LM, Brown JM (1991): scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci USA 88:1394-1397.
14. Blier PR, Griffith AJ, Craft J, Hardin JA (1993): Binding of Ku protein to DNA measurement of affinity for ends and demonstration of binding to nicks. J Biol Chem 268:7594-7601.
15. Blunt T, Finnie NJ, Taccioli GE, Smith GCM, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP (1995): Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80: 813-823.
16. Boothman DA, Fukunaga N, Wang M (1994): Down-regulation of topoisomerase I in mammalian cells following ionizing radiation. Cancer Res 54:4618-4626.
17. Bosma GC, Custer RP, Bosma MJ (1983): A severe combined immunodeficiency mutation in the mouse. Nature 301:527-530.
18. Bosma M, Carroll A (1991): The Seid mouse mutant: definition, characterization, and potential uses. Ann Rev Immunol 9:323-350.
19. Boubnov NV, Hall KT, Wills Z, Lee SE, He DM, Benjamin DM, Pulaski CR, Band H, Reeves W, Hendrickson EA, Weaver DT (1995a): Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc Natl Acad Sci USA 92:890-894.
20. Boubnov NV, Lee SE, Wills ZP, Hall KT, Hendrickson EA, Weaver DT: unpublished observation.
21. Boubnov NV, Weaver DT (1995b): Scid cells are deficient in Ku and RPA phosphorylation by the DNA-dependent protein kinase. Mol Cell Biol 15:5700-5706.
22. Boubnov NV, Wills ZP, Weaver DT (1993): V(D)J recombination coding junction formation without DNA homology: processing of coding termini. Mol Cell Biol 13:6957-6968.
23. Boubnov NV, Wills ZP, Weaver DT (1995c): Coding sequence composition flanking either signal element alters V(D)J recombination efficiency. Nucl Acids Res 23:1060-1067.
24. Brush GS, Anderson CW, Kelly TJ (1994): The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc Natl Acad Sci USA 91:12520-12524.
25. Budd ME, Campbell JL (1993): DNA polymerase δ and ε are required for chromosomal replication in Saccharomyces cerevisiae. Mol Cell Biol 13:496-505.
26. Buratowski S (1993): DNA repair and transcription: the helicase connection. Science 260:37-38.
27. Caelles C, Helmberg A, Karin M (1994): p53-dependent apoptosis in the absence of transcriptional activation of p53 target genes. Nature 370.
28. Cai QQ, Plet A, Imbert J, Lafagepochitaloff M, Cerdan C, Blanchard JM (1994): Chromosomal location and expression of the genes coding for Ku p70 and p80 in human cell lines and normal tissues. Cytogen Cell Genet 65:221-227.
29. Caldecott KW, McKeown CK, Tucker JD, Ljungquist S, Thompson LH (1994): An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Mol Cell Biol 14:68-76.
30. Cao QP, Pitt S, Leszyk J, Baril EF (1994): DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. Biochemistry 33:8548-8557.
31. Carter T, Anderson CW (1991): The DNA-activated protein kinase. Prog Mol Subcell Biol 12:37-47.
32. Carter TH, Vancurova IS, Lou W, DeLeon SP (1990): A DNA-activated protein kinase from HeLa cell nuclei. Mol Cell Biol 10:6460-6471.
33. Carty MP, Zernik-Kobak M, McGrath S, Dixon K (1994): UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J 13:2114-2123.
34. Chan JY, Backer FF, German J, Ray JH (1987): Altered DNA ligase I activity in Bloom's syndrome cells. Nature 325:357-9.
35. Chan JY-H, Becker FF (1988): Defective DNA ligase I in Bloom's syndrome cells. Simultaneous analysis using immunoblotting and the ligase-[32P] AMP adduct assay. J Biol Chem 263:18321-18325.
36. Chen DJ, Marrone BL, Nguyen T, Stackhouse M, Zhao Y, Siciliano MJ (1994): Regional assignment of a human DNA repair gene (XRCC5) to 2q35 by X-ray hybrid mapping. Genomics 21:423-427.
37. Chen DJ, Park MS, Campbell E, Oshimura M, Liu P, Zhao Y, White BF, Siciliano MJ (1992): Assignment of a human DNA double-strand break repair gene (XRCC5) to chromosome 2. Genomics13:1088-1094.
38. Chen J, Jackson PK, Kirschner MW, Dutta A (1995): Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374:386-388.
39. Chen J, Tomkinson AE, Ramos W, Mackey ZB, Danehower S, Schultz RA, Besterman JM, Husain I (1995): Mammalian DNA ligase. III. Molecular cloning, chromosomal localization and involvement in meiotic recombination during spermatogenesis. Mol Cell Biol 15:5412-5422.
40. Chou C, Wang J, Knoth M, Reeves W (1992): Role of a major autoepitope in forming the DNA binding site of the p70(Ku) antigen. J Exp Med 175:1677-1684.
41. Chui G, Linn S (1995): Further characterization of HeLa polymerase ε. J Biol Chem 270:7799-7808.
42. Cleaver JE, Morgan WF (1991): Poly(ADP-ribose) polymerase: a perplexing participant in cellular responses to DNA breakage. Mutat Res 257:1-18.
43. Coverley D, Kenny MK, Munn M, Rupp WD, Lane DP, Wood RD (1991): Requirement for the replication protein SSB in human DNA excision repair. Nature 349:538-541.
44. Danska JS, Pflumio F, Williams CJ, Huner O, Disck JE, Guidos CJ (1994): Rescue of T-cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science 266:450-455.
45. de Murcia G, Menissier de Murcia J (1994): Poly(ADP-ribose)polymerase: a molecular nick sensor. Trends Biochem Sci 19:172-176.
46. de Murcia G, Schreiber V, Molinete M, Saulier B, Poch O, Masson M, Niedergang C, Menissier de Murcia J (1994): Structure and function of poly (ADP-ribose) polymerase. Mol Cell Biochem 138:15-24.
47. deVries E, van Driel W, Bergsma WG, Arnberg AC, van der Vliet PC (1989): HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol 208:65-78.
48. Dianov G, Price A, Lindahl T (1992): Generation of single-nucleotide repair patches following excision of uracil residues from DNA. Mol Cell Biol 12: 1605-1612.
49. Din S, Brill SJ, Fairman M, Stillman B (1990): Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev 4:968-977.
50. Donehower L, Harvey M, Slagle B, McArthur M, Montgomery C, Butel J, Bradley A (1992): Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature 356:215-221.
51. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI (1994): p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-1023.
52. Dutta A, Ruppert JM, Aster JC, Winchester E (1993): Inhibition of DNA replication factor RPA by p53. Nature 365:79-82.
53. Dutta A, Stillman B (1992): cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J 11:2189-2199.
54. Dvir A, Peterson SR, Knuth MW, Lu H, Dynan W (1992): Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc Natl Acad Sci USA 89:11920-11924.
55. Eki T (1994): Poly(ADP-ribose) polymerase inhibits DNA replication by human replicative DNA polymerase alpha and epsilon in vitro. FEBS Lett 356: 261-266.
56. El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993): WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
57. Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW (1992): CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc Natl Acad Sci USA 89:2907-2911.
58. Falzon M, Fewell JW, Kuff EL (1993): EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA. J Biol Chem 268:10546-10552.
59. Feaver WJ, Svejstrup JQ, Bardwell L, Bardwell AJ, Buratowski S, Gulyas KD, Donahue TF, Friedberg EC, Kornberg RD (1993): Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair. Cell 75:1379-1387.
60. Feldman H, Winnacker EL (1993): A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae. J Biol Chem 268:12895-12900.
61. Finnie NJ, Gottlieb TM, Blunt T, Jeggo PA, Jackson SP (1995): DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci USA 92:320-324.
62. Flores-Rozas H, Kelman Z, Dean FB, Pan Z-Q, Harper JW, Elledge SJ, O'Donnell M, Hurwitz J (1994): Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci USA 91:8655-8659.
63. Fotedar R, Roberts JM (1992): Cell cycle-regulated phosphorylation of RPA-32 occurs within the replication initiation complex. EMBO J 11:2177-2187.
64. Fuchs B, O'Connor D, Fallis L, Scheidtmann KH, Lu X (1995): p53 phosphorylation mutants retain transcription activity. Oncogene 10:789-793.
65. Fulop GM, Phillips RA (1990): The scid mutation in mice causes a general defect in DNA repair. Nature 347:479-482.
66. Gellert M (1992): Molecular analysis of V(D)J recombination. Annu Rev Genet 22:425-446.
67. Genersch E, Eckerskorn C, Lottspeich F, Herzog C, Kuhn K, Poschl E (1995): Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. EMBO J 14.
68. Getts RC, Stamato TD (1994): Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant. J Biol Chem 269: 15981-15984.
69. Giaccia AJ, Denko N, MacLaren R, Mirman D, Waldren C, Hart I, Stamato TD (1990): Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant. Am J Hum Genet 47:459-469.
70. Gottlieb TM, Jackson SP (1993): The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72:131-142.
71. Griffith AJ, Blier PR, Mimori T, Hardin JA (1992): Ku polypeptides synthesized in vitro assemble into complexes which recognize ends of double-stranded DNA. J Biol Chem 267:331-338.
72. Halazonetis TD, Davis LJ, Kandil AN (1993): Wild-type p53 adopts a "mutant"-like conformation when bound to DNA. EMBO J 12:1021-1028.
73. Hamatake RK, Hasegawa H, Clark AB, Bebenek K, Kunkel TA, Sugino A (1990): Purification and characterization of DNA polymerase II from the yeast Saccharomyces cerevisiae. Identification of the catalytic core and a possible holoenzyme form of the enzyme. J Biol Chem 265:4072-4083.
74. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993): The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805-816.
75. Hartwell LH, Kastan MB (1994): Cell cycle control and cancer. Science 266:1821-1828.
76. He, Z, Brinton BT, Greenblatt J, Hassell JA, Ingles CJ (1993): The transactivator proteins VP16 and GAL4 bind replication factor A. Cell 73:1223-1232.
77. He, Z, Henricksen LA, Wold MS, Ingles CJ (1995): RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature 374:566-569.
78. Hendricksen LA, Wold MS (1994): Replication protein A mutants lacking phosphorylation sites for p34-cdc2 kinase support DNA replication. J Biol Chem 269:24203-24208.
79. Hendrickson EA, Liu VF, Weaver DT (1991): Strand breaks without DNA rearrangement in V(D)J recombination. Mol Cell Biol 11:3155-3162.
80. Hendrickson EA, Qin X-Q, Bump EA, Schatz DG, Oettinger M, Weaver DT (1991): A link between double-strand break-related repair and V(D)J recombination: the scid mutation. Proc Natl Acad Sci USA 88:4061-4065.
81. Hendrickson EA, Schatz DG, Weaver DT (1988):The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement. Genes Dev 2:817-829.
82. Hendrickson EA, Schlissel MS, Weaver DT (1990): Wild-type V(D)J recombination in scid pre-B cells. Mol Cell Biol 10:5397-5407.
83. Higashiura M, Shimizu Y, Tanimoto M, Monta T, Yagura T (1992): Immunolocalization of Ku-proteins (p80/p70): localization of p70 to nucleoli and periphery of both interphase nuclei and metaphase chromosomes. Exp Cell Res 201:444-451.
84. Hoff CM, Ghosh AK, Prabhakar BS, Jacob ST (1994): Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. Proc Natl Acad Sci USA 91:762-766.
85. Hupp TR, Lane DP (1994): Allosteric activation of latent p53 tetramers. Curr Biol 4:865-875.
86. Husain I, Toomkinson AE, Burkhart WA, Moyer MB, Ramos W, Mackey ZB, Besterman JM, Chen J (1995): Purification and characterization of DNA ligase III from bovine testes. J Biol Chem 270:9683-9690.
87. Iijima S, Teraoka H, Date T, Tsukada K (1992): DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-myc oncoprotein. Eur J Biochem 206:595-603.
88. Jacks T, Remington L, Williams B, Schmitt EM, Halachni S, Bronson RT, Weinberg RA (1994): Tumor spectrum analysis in p53-mutant mice. Curr Biol 4:1-7.
89. Jackson SP, MacDonald JJ, Lees-Miller S, Tjian R (1990): GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase. Cell 63:155-165.
90. Jacoby DB, Wensink PC (1994): Yolk protein factor-1 Drosophila homolog of Ku, the DNA-binding subunit of a DNA-dependent protein kinase from humans. J Biol Chem 269:11484-11491.
91. Jayaraman L, Prives C (1995): Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81: 1021-1029.
92. Jeggo P (1990): Studies on mammalian mutants defective in rejoining double-strand breaks in DNA. Mutat Res 239:1-16.
93. Jeggo P, Hafezparast M, Thompson AF, Broughton BC, Kaur GP, Zdzienicka MZ, Athwal RS (1992): Localization of a DNA repair gene (XRCC5) involved in double-strand-break rejoining to human chromosome 2. Proc Natl Acad Sci USA 89:6423-6427.
94. Jeggo P, Hafezparast M, Thompson AF, Kaur GP, Sandhu AK, Athwal RS (1993): A hamster-human subchromosomal hybrid cell panel for chromosome 2. Somat Cell Mol Genet 19:39-49.
95. Jeggo PA (1985): Genetic analysis of X-ray-sensitive mutants of the CHO cell line. Mutat Res 146:265-270.
96. Jeggo PA (1985): X-ray-sensitive mutants of Chinese hamster ovary cell line: radiosensitivity of DNA synthesis. Mutat Res 145:171-176.
97. Jeggo PA, Caldecott K, Pidsley S, Banks G (1989): Sensitivity of Chinese hamster ovary mutants defective in DNA double-strand break repair to topoisomerase II inhibitors. Cancer Res 49:7057-7063.
98. Jeggo PA, Kemp LM (1983): X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents. Mutat Res 112:313-327.
99. Jeggo PA, Tesmer J, Chen DJ (1991): Genetic analysis of ionising radiation-sensitive mutants of cultured mammalian cells. Mutat Res 254:125-133.
100. Jessberger R, Berg P (1991): Repair of deletions and double-strand gaps by homologous recombination in a mammalian in vitro system. Molec Cell Biol 11:445-457.
101. Jessberger R, Podust V, Hubscher U, Berg P (1993): A mammalian protein complex that repairs double-strand breaks and deletions by recombination. J Biol Chem 268:15070-15079.
102. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace JAJ (1992): A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in Ataxia-Telangiectasia. Cell 71:587-597.
103. Kern SE, Kinzler DW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B (1991): Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708-1711.
104. Kern SE, Pietenpol JA, Thiagalingam S, Seymour A, Kinzler KW, Vogelstein B (1992): Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256:827-830.
105. Kesti T, Frantti H, Syvaoja JE (1993): Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase ε. J Biol Chem 268:10238-10245.
106. Kirchgessner C, Tosto L, Biederman K, Kovacs M, Araujo D, Stanbridge E, Brown J (1993): Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8. Cancer Res 53:6011-6016.
107. Kirchgessner CU, Patil CK, Evans JW, Cuomo, CA, Fried LM, Carter T, Oettinger MA, Brown JM (1995): DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178-1183.
108. Knuth M, Gunderson S, Thompson N, Straheim L, Burgess R (1990): Purification and characterization of PSE1, a transcription-activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. J Biol Chem 265:17911-17920.
109. Komatsu K, Ohta T, Jinno Y, Niikawa N, Okumura Y (1993): Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8. Hum Mol Genet 2:1031-1034.
110. Komatsu K, Yoshida M, Okumura Y (1993): Murine scid cells complement ataxia-telangiectasia cells and show a normal post-irradiation response of DNA synthesis. Int J Rad Biol 63:725-730.
111. Koonin E (1993): Nucl Acids Res 21:2541-2547.
112. Kuerbitz S, Plunkett B, Walsh W, Kastan M (1992): Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89:7491-7495.
113. Kuhn A, Gottlieb TM, Jackson SP, Grummt I (1995): DNA-dependent protein kinase: a potent inhibitor of transcription by RNA polymerase I. Genes Dev 9: 193-203.
114. Kuhn A, Stefanovsky V, Grummt I (1993): The nucleolar transcription activator UBF relieves Ku antigen-mediated repression of mouse ribosomal gene transcription. Nucl Acids Res 21:2057-2063.
115. Kupper JH, Muller M, Jacobson MK, Tatsumi-Miyajima J, Coyle DL, Jacobson EL, Burkle A (1995): trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against y-irradiation and N-methyul-N-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon. Mol Cell Biol 15:3154-3163.
116. Kurimasa A, Nagata Y, Shimizu M, Emi M, Nakamura Y, Oshimura M (1993): A human gene that restores the DNA-repair defect in scid mice is located on 8p11.1-q11.1. Hum Genet 93:21-26.
117. Labhart P (1995): DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I. Proc Natl Acad Sci USA 92:2934-2938.
118. Lai JS, Herr W (1992): Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein association. Proc Natl Acad Sci USA 89: 6958-6962.
119. Lane DP (1992): p53, guardian of the genome. Nature 358:15-16.
120. Lazebnik YA, Kaaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC (1994): Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature 371:346-347.
121. Lee S, Elenbaas B, Levine A, Griffith J (1995): p53 and its 14-kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81:1013-1020.
122. Lee SE, Pulaski CR, He DM, Benjamin DM, Voss MJ, Um J, Hendrickson EA (1995): Isolation of mammalian cell mutants that are X-ray-sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination. Mutat Res 336:279-291.
123. Lees-Miller SP, Chen Y, Anderson CW (1990): Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol 10:6472-6481.
124. Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day RS, Barron GM, Allalunis-Turner J (1995): Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science 267:1183-1185.
125. Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW (1992): Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the aminoterminal transactivation domain of human p53. Mol Cell Biol 12:5041-5049.
126. Lewis SM (1994): The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Adv Immunol 56:27-150.
127. Li GC, Yang SH, Kim D, Nussensweig A, Ouyang H, Wei J, Burgman P, Li L (1995): Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proc Natl Acad Sci USA 92:4512-4516.
128. Li R, Botchan MR (1993): The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell 73:1207-1221.
129. Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M (1988): The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell 55:7-16.
130. Lieberman M, Hansteen GA, Waller EK, Weissman IL, Sen-Majumdar A (1992): Unexpected effects of the severe combined immunodeficiency mutation on murine lymphomagenesis. J Exp Med 176: 399-405.
131. Liu SH, Ma, JT, Yueh AY, Lees-Miller SP, Anderson CW, Ng SY (1993): The carboxyl-terminal transactivation domain of human serum response factor contains DNA-activated protein kinase phosphorylation sites. J Biol Chem 268:21147-21154.
132. Liu V, Weaver D (1993): The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol Cell Biol 13:7222-7231.
133. Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD (1992): Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923-935.
134. Ljungquist S, Kenne K, Olsson L, Sandstrom M (1994):Altered DNA ligase III activity in the CHO EM9 mutant. Mutat Res 314:177-186.
135. Lowe SW, Ruley HE, Jacks T, Housman DE (1993): p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-967.
136. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993): p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
137. Lu X, Lane DP (1993): Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromsome instability syndromes? Cell 75:765-778.
138. Luo Y, Hurwitz J, Massague J (1995): Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375:159-161.
139. Macleod KF, Sherry N, Hannon G, Beach D, Tokino T, Kinzler K, Vogelstein B, Jacks T (1995): p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev 9:935-944.
140. Maltzman W, Czyzyk L (1984): UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol 4:1689-1694.
141. Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJW, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW (1988): The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism. Cell 54:453-460.
142. Messier H, Fuller T, Mangal S, Brickner H, Igarashi S, Gaikwad J, Fotedar R, Fotedar A (1993): p70 lupus autoantigen binds the enhancer of the T-cell receptor β-chain gene. Proc Natl Acad Sci USA 90:2685-2689.
143. Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S, Homma M (1981): J Clin Invest 68:611-620.
144. Mimori T, Hardin JA (1986): Mechanism of interaction between Ku protein and DNA. J Biol Chem 261:10375-10379.
145. Mimori T, Hardin JA, Steitz JA (1986): Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J Biol Chem 261:2264-2278.
146. Mohrenweiser HW, Carrano AV, Fertitta A, Perry B, Thompson LH, Tucker JD, Weber CA (1989): Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1 on human chromosome 19. Cytogenet Cell Genet 52:11-14.
147. Molinete M, Vermeulen W, Burkle A, Menissier-de Murcia J, Kupper JH, Hoeijmakers JHJ, de Murcia G (1993): Overproduction of the poly ( ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J 12:2109-2117.
148. Morrison AL, Araki H, Clark AB, Hamatake RK, Sugino A (1990): A third essential DNA polymerase in S. cerevisiae. Cell 62:1142-1151.
149. Murphy WJ, Durum SK, Anver MR, Ferris DK, McVicar DW, O'Shea JJ, Ruscetti SK, Smith MR, Young HA, Longo DL (1994): Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID). J Immunol 153:1004-1014.
150. Navas TA, Zhou Z, Elledge SJ (1995): DNA polymerase ε links the replication machinery to the S phase checkpoint. Cell 80:29-39.
151. Nicholson DW, Ali A, Thornberry NA, Vailancourt JP, Ding CK, Gallant M, Gareau Y, Griffin PR, Labelle M, Lazebnik YA, Munday NA, Raju SM, Smulson ME, Yamin T-T, Yu VL, Miller DK (1995): Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37-43.
152. Niu H, Jacob ST (1994): Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells. Proc Natl Acad Sci USA 91:9101-9105.
153. Oberosler P, Hloch P, Ramsperger U, Stahl H (1993): p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J 12:2389-2396.
154. Oettinger MA, Schatz DG, Gorka C, Baltimore D (1990): RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517-1523.
155. Ono M, Tucker PW, Capra JD (1994): Production and characterization of recombinant human Ku antigen. Nucl Acids Res 22:3918-3924.
156. Paillard S, Strauss F (1991): Analysis of the mechanism of interaction of simian Ku protein with DNA. Nucl Acids Res 19:5619-5624.
157. Pan ZQ, Amin AA, Gibbs E, Niu HW, Hurwitz J (1994): Phosphorylation of the p34 subunit of human single-stranded DNA binding protein in cyclin A-activated G(1) extracts is catalyzed by CDK cyclin A complex and DNA-dependent protein kinase. Proc Natl Acad Sci USA 91:8343-8347.
158. Paules RS, Levedakou EN, Wilson SJ, Innes CL, Rhodes N, Tlsty TD, Galloway DA, Donehower LA, Tainsky MA, Kaufmann WK (1995): Defective G2 checkpoint function in cells from individuals with familial cancer syndromes. Cancer Res 55:1763-1773.
159. Pergola F, Zdzienicka MZ, Lieber MR (1993): V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair. Mol Cell Biol 13:3464-3471.
160. Peterson SR, Dvir A, Anderson CW, Dynan WS (1992): DNA binding provides a signal for phosphorylation of the RNA polymerase II heptapeptide repeats. Genes Dev 6:426-438.
161. Peterson SR, Kurimasa A, Oshimura M, Dynan WS, Bradbury EM, Chen DJ (1995): Loss of the 350 kDa catalytic subunit of the DNA-dependent protein kinase in DNA double-strand break repair mutant mammalian cells. Proc Natl Acad Sci USA 92:3171-3174.
162. Petrini JH, Huwiler KG, Weaver DT (1991): A wild-type DNA ligase I gene is expressed in Bloom's syndrome cells. Proc Natl Acad Sci USA 88:7615-9.
163. Petrini JHJ, Donovan JW, DiMare C, Weaver DT (1994): Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes. J Immunol 152:176-183.
164. Petrini JHJ, Walsh M, DiMare C, Chen X-N, Korenberg JR, Weaver DT (1995): Isolation and characterization of the human MRE11 homologue. Genomics 29:80-86.
165. Petrini JHJ, Xiao Y, Weaver DT (1995): DNA ligase I mediates essential functions in mammalian cells. Mol Cell Biol 15:4303-4308.
166. Picksley SM, Meek DW, Lane DP (1992): The conformational change of a murine temperature-sensitive p53 protein is independent of a change in phosphorylation status. Oncogene 7:1649-1651.
167. Prives C (1994): How loops, β sheets, and α helices help us to understand p53. Cell 78:543-546.
168. Rathmell WK, Chu G (1994): A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Mol Cell Biol 14:4741-4748.
169. Rathmell WK, Chu G (1994): Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Proc Natl Acad Sci USA 91:7623-7627.
170. Reeves W (1985): Use of monoclonal antibodies for the characterization of novel DNA-binding proteins recognized by human autoimmune sera. J Exp Med 161:18-39.
171. Reeves WH, Sthoeger ZM (1989): Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. J Biol Chem 264:5047-5052.
172. Roberts MR, Han Y, Fienberg A, Hunihan L, Ruddle FH (1994): A DNA-binding activity, TRAC, specific for the TRA element of the transferrin receptor gene copurifies with the Ku autoantigen. Proc Natl Acad Sci USA 91:6354-6358.
173. Roth DB, Chang X-B, Wilson JH (1989): Comparison of filler DNA at immune, nonimmune, and oncogenic rearrangements suggests multiple mechanisms of formation. Mol Cell Biol 9:3049-3057.
174. Roth DB, Menetski JP, Nakajima PB, Bosma MJ, Gellert M (1992): V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
175. Roth DB, Nakajima PB, Menetski JP, Bosma MJ, Gellert M (1992): V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69:41-53.
176. Roth DB, Zhu C, Gellert M (1993): Characterization of broken DNA molecules associated with V(D)J recombination. Proc Natl Acad Sci USA 90: 10788-10792.
177. Satoh M, Wang J, Reeves WH (1995): Role of free p70 (Ku) subunit in posttranslational stabilization of newly synthesized p80 during DNA-dependent protein kinase assembly. Eur J Cell Biol 66:127-135.
178. Satoh MS, Lindahl T (1992): Role of poly(ADP-ribose) formation in DNA repair. Nature 356:356-358.
179. Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, Vanagaite L, Tagle DA, Smith S, Uziel T, Sfez S, Ashkenazi M, Pecker I, Frydman M, Harnik R, Patanjali SR, Simmons A, Clines GA, Sartiel A, Gatti RA, Chessa L, Sanal O, Lavin MF, Jaspers NGJ, Taylor AMR, Arlett CF, Miki T, Weissman SM, Lovett M, Collins FS, Shiloh Y (1995): A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-1753.
180. Schatz D, Oettinger MA, Baltimore D (1989): The V(D)J recombination activating gene RAG-1. Cell 59:1035-1048.
181. Schlissel M, Constantinescu A, Morrow T, Baxter M, Peng A (1993): Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated. Genes Dev 7:2520-2532.
182. Schreiber V, Hunting D, Trucco C, Gowans B, Grunwald D, de Murcia G, Menissier de Murcia J (1995): A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc Natl Acad Sci USA 92:4753-4757.
183. Schuler W (1990): The scid mouse mutant: biology and nature of the defect. In: C S (ed) "Molecular Biology of B Cell Developments." Basel, Switzerland: Karger, 132-173.
184. Schuler W, Weiler IJ, Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ (1986): Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46:963-972.
185. Sheehan KM, Lieber MR (1993): V(D)J recombination: signal and coding joint resolution are uncou-pled and depend on parallel synapsis of the sites. Mol Cell Biol 13:1363-1370.
186. Shimma Y, Uno I (1990): Isolation and characterization of neomycin-sensitive mutants in Saccharomyces cerevisiae. J Gen Microbiol 136:1753-1761.
187. Shivji MKK, Kenny MK, Wood RD (1992): Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69:367-374.
188. Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW (1995): The gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8. Proc Natl Acad Sci USA 92:7515-7519.
189. Smider V, Rathmell WK, Lieber MR, Chu G (1994): Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266: 288-291.
190. Smith ML, Chen IT, Zhan Q, Bae IS, Chen C, Gilmer T, Kastan M, O'Conner P, Fornace A (1994): Interaction of the p53-regulated protein GADD45 with proliferating cell nuclear antigen. Science 266:1376-1380.
191. Stackhouse MA, Ortiz JB, Sato K, Chen DJ (1994): Functional complementation of the radiation-sensitive mutant M10 cell line by human chromosome 5. Mutat Res 323:47-52.
192. Stamato TD, Weinstein R, Giaccia A, Mackenzie L (1983): Isolation of cell cycle-dependent gamma-ray-sensitive Chinese hamster ovary cell. Somat Cell Genet 9:165-173.
193. Strasser A, Harris AW, Corcoran LM, Cory S (1994): Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 368:457-460.
194. Suwa A, Hirakata M, Takeda Y, Jesch SA, Mimori T, Hardin JA (1994): DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc Natl Acad Sci USA 91:6904-6908.
195. Szpirer J, Pedeutour F, Kesti T, Riviere M, Syvaoja JE, Turc-carel C, Szpirer C (1994): Localization of the gene for DNA polymerase ε (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and florescence in situ hybridization. Genomics 20:223-226.
196. Taccioli G, Gottlieb TM, Blunt T, Priestly A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA (1994): Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265:1442-1445.
197. Taccioli GE, Cheng H-L, Varghese AJ, Whitmore G, Alt FW (1994): A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine Scid mutation. J Biol Chem 269:7439-7442.
198. Taccioli GE, Rathbun G, Oltz E, Stamato T, Jeggo PA, Alt FW (1993): Impairment of V(D)J recombination in double-strand break repair mutants. Science 260:207-210.
199. Thompson LH, Brookman KW, Dillehay LE, Carrano AV, Mazrimas JA, Mooney CL, Minkler JL (1982): A CHO-cell strain having hypersensitivity to mutagens, a defect in strand-break repair, and an extraordinary baseline frequency of sister chromatid exchange. Mutat Res 95:247-440.
200. Thompson LH, Brookman KW, Jones NJ, Allen SA, Carrano AV (1990): Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange. Mol Cell Biol 10:6160-6171.
201. Thompson LH, Jeggo PA (1996): Nomenclature of human genes involved in ionizing radiation sensitivity. Mutat Res in press.
202. Tlsty TD, Briot A, Gualberto A, Hall I, Hess S, Hixon M, Kuppuswamy D, Romanov S, Sage M, White A (1995): Genomic instability and cancer. Mutat Res 337:1-7.
203. Tomkinson AE, Roberts E, Daly G, Totty NF, Lindahl T (1991): Three distinct DNA ligases in mammalian cells. J Biol Chem 266:21728-35.
204. Tonegawa S (1983): Somatic generation of antibody diversity. Nature 302:575-581.
205. Toth EC, Marusic L, Ochem A, Patthy A, Pongor S, Giacca M, Falaschi A (1993): Interactions of USF and Ku antigen with a human DNA region containing a replication origin. Nucl Acids Res 21:3257-3263.
206. Tsurimoto T, Stillman B (1989): Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases, alpha and delta. EMBO J 8:3882-3889.
207. Tuteja N, Tuteja R, Ochem A, Taneja P, Huang NW, Simoncsits A, Susic S, Rahman K, Marusic L, Chen J, Zhang J, Wang S, Pongor S, Falaschi A (1994): Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J 13:4991-5001.
208. van Gent DC, McBlane JF, Ramsden DA, Sadofsky MJ, Hesse JE, Gellert M (1995): Initiation of V(D)J recombination in a cell-free system. Cell 81:925-934.
209. Vishwanatha JK, Baril EF (1990): Single-stranded DNA-dependent ATPase from HeLa cells that stimulates DNA polymerase α-primase activity: purification and characterization of the ATPase. Biochemistry 29:8753-8759.
210. Waga S, Hannon GJ, Beach D, Stillman B (1994): The p21 inhibitor of cyclin-dependent kinases controls of DNA replication by interaction with PCNA. Nature 369:574-578.
211. Waga S, Stillman B (1994): Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature 369:207-212.
212. Walker AI, Hunt T, Jackson RJ, Anderson CW (1985): Double-stranded DNA induces the phosphorylation of several proteins including the 90,000 Mr heatshock protein in animal cell extracts. EMBO J 4: 139-145.
213. Walker JE, Saraste M, Runswick MJ, Gay NJ (1982): EMBO J 1:945-951.
214. Walter CA, Lu J, Bhakta M, Zhou ZQ, Thompson LH, McCarrey JR (1994): Testis and somatic Xrcc-1 DNA repair gene expression. Somat Cell Mol Genet 20:451-461.
215. Wang J, Satoh M, Pierani A, Schmitt J, Chou C-H, Stunnenberg HG, Roeder RG, Reeves WH (1994): Assembly and DNA binding of recombinant Ku (p70/ p80) autoantigen defined by a novel monoclonal antibody specific for p70/p80 heterodimers. J Cell Sci 107:3223-3233.
216. Wang Z, Wu X, Friedberg EC (1993): DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase ε and is influenced by DNA polymerase α and δ in Saccharomyces cerevisiae. Mol Cell Biol 13:1051-1058.
217. Weaver D (1994): V(D)J recombination and double-strand break repair. Adv Immunol 58:29-85.
218. Wei Y-F, Robbins P, Carter K, Caldecott K, Pappin DJC, Yu G-L, Wang R-P, Shell BK, Nash RA, Schar P, Barnes DE, Haseltine WA, Lindahl T (1995): Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination. Mol Cell Biol 15:3206-3216.
219. Weibezahn KF, Lohrer H, Herrlich P (1985): Double-strand break repair and G2 block in Chinese hamster ovary cells and their radiosensitive mutants. Mutat Res 145:177-183.
220. White AE, Livanos EM, Tlsty TD (1994): Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev 8:666-677.
221. Whitmore GF, Varghese AJ, Gulyas S (1989): Cell cycle responses of two X-ray-sensitive mutants defective in DNA repair. Int J Radiat Biol 56:657-665.
222. Willis AE, Lindahl T (1987): DNA ligase I deficiency in Bloom's syndrome. Nature (London) 325:355-357.
223. Willis AE, Weksberg R, Tomlinson S, Lindahl T (1987): Structural alterations of DNA ligase I in Bloom syndrome. Proc Natl Acad Sci USA 84:8016-8020.
224. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993): p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704.
225. Yaneva M, Busch H (1986): A 10S particle released from deoxyribonuclease-sensitive regions of HeLa cell nuclei contains the 86-kilodalton 70-kilodalton protein complex. Biochemistry 25:5057-5063.
226. Yaneva M, Jhiang S (1991): Expression of the Ku protein during cell proliferation. Biochim Biophys Acta 1090:181-187.
227. Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM (1992): Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
228. Yoshida M, Shimma YI, Uno I, Toh-e A (1994): Cloning and sequencing of the NES24 Gene of Saccharomyces cerevisiae. Yeast 10:371-376.
229. Zdzienicka MZ, Tran Q, van der Schans GP, Simons JWIM (1988): Characterization of an X-ray-hypersensitive mutant of V79 Chinese hamster cells. Mutat Res 194:239-249.
230. Zhang WW, Yaneva M (1992): On the mechanisms of Ku protein binding to DNA. Biochem Biophys Res Commun 186:574-579.
231. Zhang WW, Yaneva M (1993): Reduced sulfydryl groups are required for DNA binding of Ku protein. Biochem J 293:769-774.