Inhibition of in vitro HIV infection by dialysable leucocyte extracts

Biotherapy

Volumn 9, Issue 1-3, 1996, Pages 33-40

  Fernandez Ortega, C ^a   Dubed, M ^a   Ruibal, O ^b   Vilarrubia, O L ^a   Menendez De San Pedro J C ^a   Navea, L ^a   Ojeda, M ^a   Arafia, M J ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b Laboratory for AIDS Research   (Cuba)

Author keywords

dialysable leucocyte extract; human immunodeficiency virus; MT 4 cell line

Indexed keywords

ANTIGEN P24; LEUKOCYTE EXTRACT; RNA DIRECTED DNA POLYMERASE;

ANTIVIRAL ACTIVITY; CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DIALYSATE; FRACTIONATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE CULTURE; MOLECULAR WEIGHT; PRIORITY JOURNAL; SUPERNATANT; VIRUS REPLICATION;

EID: 0029751811     PISSN: 0921299X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02628654     Document Type: Conference Paper

References (28)

1. Borrow P, Lewicki H, Hahn BH, Shaw GM & Oldstone, MBA. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary Human Immunodeficiency Virus type 1 infection. J Virol 1994; 68: 6103-10.
2. Saag MS, Hammer SM & Lange JMA. Pathogenicity and diversity of HIV and implications for clinical management: A review. J AIDS 1994; 7: S2-S11.
3. Stein DS, Timpone JG, Gradon JD, Kagan JM & Schnittman SM. Immune-based therapeutics: Scientific rationale and the promising approaches to the treatment of the HlV-infected individual. Clin Inf D 1993; 17: 749-71.
4. Salk PL & Salk J. Cell-mediated immunologie memory in prevention and treatment of HIV disease. Res Immunol 1994; 145: 629- -35.
5. Lawrence HS: The transfer in humans of delayed skin sensitivity to streptococcal M substance and to tuberculin with disrupted leukocytes. J Clin Inv 1955; 34: 219-24.
6. Kirkpatrick CH & Greenberg LE. Treatment of chronic mucocutaneous candidiasis with Transfer Factor. In: Khan A, Kirkpatrick CH, Hill NO, eds. Immune regulators in Transfer Factor. New York: Academic Press, 1979: 547-59.
7. Gottlieb AA & Gottlieb MS. Clinical and biological effects of IMREG-1 and IMREG-2, two immunologically active components of leukocyte dialysates. In: Fujisawa T, Sasakawa S, eds. Recent advances in Transfer Factor and Dialyzable Leukocyte Extracts. Tokyo: Maruzen Co, 1990: 2-10.
8. Sargent IL, Salaman MR & Valdimarsson H. Effect of Transfer Factor (TF) and thymosin on the recovery of E-rosetting capacity in trypsinised lymphocytes. In: Khan A, Kirkpatrick CH, Hill NO, eds. Immune regulators in Transfer Factor. New York: Academic Press, 1979: 129-35.
9. Drofling P & Schröder I. Effect of Dialyzable Leukocyte Extract and its different fractions on the production of H2O2 and IL-1 by macrophages. In: Mayer V, Borvak J, eds. Leukocytes Dialysates and Transfer Factor, Bratislava: Slovak Academy, 1987: 141
10. Fudenberg HH, Spitler LE & Levin AS. Treatment of immunodeficiency. Am J Path 1972; 69: 529-36.
11. Blume MR, Rosenbaum EH, Cohen RJ, Gershow J,Glassberg AB & Shepley E. Adyuvant Immunotherapy of high risk stage I melanoma with Transfer Factor. Cancer 1981; 47: 882-88.
12. Louie E, Borkowsky W, Klesius PH, Haynes TB.Gordon S, Bonk S & Lawrence HS. Treatment of cryptosporidiosis with oral bovine Transfer Factor. Clin Imm Im 1987; 44: 329-34.
13. Cabezas R, Estrada S, Padiema L, Fernandez-Ortega C & Lopez P. Inmuterapia con Factor de Transferencia en pacientes con herpes zoster. Biotecnologia Aplicada 1990; 7: 52-7.
14. Prochazkova J, Parizkova E, Horacek J, Pozler O, Chylkova V, Turkova M & Hanovcova I. Clinical and immunological improvement in infants with HCMV infection treated with DLE. In: Mayer V, Borvak J, eds. Leukocytes Dialysates and Transfer Factor. Bratislava: Slovak Academy, 1987: 403-11.
15. Roda E, Viza D, Pizza G, Mastroroberto L, Philips J, De Vinci C & Barbara L. Transfer Factor for the treatment of HBsAgpositive chronic active hepatitis. Proc Soc Exp Biol Med 1985; 178: 468-75.
16. Cabezas R, Estrada S, Padierna J, Ysla R, Diaz delà Rocha A, Sagaro B, Gonzalez E, Diaz Z, Cortina M, Fernandez-Ortega C & Lopez P. Effects of DLE in patients with herpes. In: Baolai H, Ruzhang W, Zhaofen Z, eds. Research and applications of Transfer Factor and DLE. Beijing: Xue Yuan Press, 1989: 294-307.
17. Carey JT, Michael MD, Lederman MM, Toossi Z,Edmonds K, Hodder S, Calabrese LH, Proffit MR, Johnson CE & Ellner JJ. Augmentation of skin test reactivity and lymphocyte blastogenesis in patients with AIDS treated with Transfer Factor. JAMA 1987; 257: 651-55.
18. Schmidtmayerova H, Chermann JC, Rey EBarre-Sinoussi F & Mayer V. The effect of the lysed leukocyte ultrafiltrate on the HIV: in vitro study. In: Mayer V, Borvak J, eds. Leukocytes Dialysates and Transfer Factor. Bratislava: Slovak Academy, 1987: 366-76.
19. Lee MH, Sano K, Morales FE & Imagawa DT. Sensitive reverse transcriptase assay to detect and quantitate human immunodeficiency virus. J Clin Micr 1987; 25:1717-21.
20. Yarchoan R, Mitsuya H & Broder S. Challenges in the therapy of HIV infection. Immunol Tod 1993; 14: 303-8.
21. Klesius P, McMeeking A, Borkowsky W, Bonk S.Holzman RS & Lawrence HS. Immunotherapy of cryptosporidium parvum with bovine Transfer Factor. In: Baolai H, Ruzhang W, Zhaofen Z, eds. Research and applications of Transfer Factor and DLE. Beijing: Xue Yuan Press, 1989: 227-38.
22. Butera ST, Roberts BD & Folks TM. Regulation of HIV-1 expression by cytokine networks in a CD4+ model of chronic infection. J Immunol 1993; 150: 625-34.
23. Poli G & Fauci AS. The effect of cytokines and pharmacologie agents on chronic HIV infection. AIDS Res Human Retro 1992; 8: 191- -96.
24. Folks TM, Clouse KA, Justement JS, Rabson A, DuhE, Kehrl JH & Fauci AS. Tumor necrosis factor alpha induces expression of HIV in a chronically infected T-cell clone. Proc Natl Acad Sei 1989; 86: 2365-69.
25. Harada S, Koyanagi Y & Yamamoto N. Infection of HTLV-III/ LAV in HTLV-1-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 1985; 229: 563-66.
26. Ito M, Baba M, Sato A, Hirabayashi K, Tanabe F, Shigeta S & DeClercq E. Tumor necrosis factor enhances replication of human immunodeficiency virus in vitro. Bioc Biop R 1989; 158: 307-12.
27. Kobayashi N, Hamamoto Y & Yamamoto N. Production of tumor necrosis factors by T cell lines infected with HTLV-1 may cause their high susceptibility to human immunodeficiency virus infection. Med Microbi 1990; 179: 115-22.
28. Borvak J & Schmidtmayerova H. Inhibition of HIV-1 reverse transcriptase activity by HPLC fractions of lysed leukocyte ultrafiltrate. In: Fujisawa T, Sasakawa S, eds. Recent Advances in Transfer Factor and Dialyzable Leukocyte Extracts. Tokyo: Maruzen Co, 1990: 87-93.