Dual regulation of cerebrovascular tone by UTP: P(2U) receptor-mediated contraction and endothelium-dependent relaxation

British Journal of Pharmacology

Volumn 118, Issue 4, 1996, Pages 847-856

  Miyagi, Yasushi ^a   Kobayashi, Sei ^a   Nishimura, Junji ^a   Fukui, Masashi ^a   Kanaide, Hideo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Ca2+ sensitivity; Cerebral vasospasm; Endothelium; Endothelium derived relaxing factor; Intracellular calcium; Smooth muscle; U 46619; UTP

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; CALCIUM ION; ENDOTHELIUM DERIVED RELAXING FACTOR; FURA 2; INDOMETACIN; N(G) NITROARGININE; PURINE P2 RECEPTOR; URIDINE TRIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; BRAIN BLOOD VESSEL; CALCIUM CELL LEVEL; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DESENSITIZATION; FLUOROMETRY; MIDDLE CEREBRAL ARTERY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

EID: 0029744650     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15477.x     Document Type: Article

References (38)

1. ABE, S., KANAIDE, H. & NAKAMURA. M. (1990). Front-surface fluorometry with fura-2 and effects of nitroglycerin on cytosolic calcium concentrations and on tension in the coronary artery of the pig. Br. J. Pharmacol., 101, 545-552.
2. ANGUS, J.A., BROUGHTON, A. & MULVANY, M.J. (1988). Role of α-adrenoceptors in constrictor responses of rat, guinea pig and rabbit small arteries to neural activation. J. Physiol, 403, 495-510.
3. APRIGLIANO, O. & HERMSMEYER, K. (1976). In vitro denervation of the portal vein and caudal artery of the rat. J. Pharmacol. Exp. Ther., 198, 568-577.
4. BENHAM, C.D. (1989). ATP-activated channels gate calcium entry in single smooth muscle cells dissociated from rabbit ear artery. J. Physiol., 419, 689-701.
5. 2 purinoceptor? Gen. Pharmacol., 16, 433-440.
6. DEMOLLE, D., LAGNEAU, C. & BOEYNAEMS, J.M. (1988). Stimulation of prostacyclin release from aortic smooth muscle cells by purine and pyrimidine nucleotides. Eur. J. Pharmacol., 155, 339-343.
7. ERLINGE, D., YOO, H., EDVINSSON, L., REIS, D.J. & WAHLESTEDT, C. (1993). Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitter. Am. J. Physiol., 265, H1089-H1097.
8. FUJIWARA. S., KASSEL, N.F., SASAKI, T., NAKAGOMI. T. & LEHMAN, R.M. (1986). Selective hemoglobin inhibition of endothelium-dependent vasodilation of rabbit basilar artery. J. Neurosurg., 64, 445-452.
9. HARDEBO, J.E., KÅHRSTRÖM, C., OWMAN, C. & SALFORD. L.G. (1987). Endothelium-dependent relaxation by uridine tri- and diphosphate in isolated human pial vessels. Blood Vessels. 24, 150-155.
10. IGNARRO. L.J. & KADOWITZ, P.J. (1987). The pharmacological and physiological role of cyclic GMP in vascular smooth muscle relaxation. Annu. Rev. Pharmacol. Toxicol., 25, 171-191.
11. i, membrane potential and force in isolated rat small arteries. J. Vasc. Res., 29, 385-395.
12. KEPPLER, D., RUDIGER, J. & DECKER, K. (1970). Enzymatic determination of uracil nucleotides in tissues. Anal. Biochem., 38, 105-114.
13. 2+-sensitivity by agonists in smooth muscle. In Regulation of Smooth Muscle Contraction, ed. Moreland, R.S. pp. 97-109. New York: Plenum Press.
14. 2+ sensitization. Am. J. Physiol., 260, C364-C370.
15. G-nitro-L-arginine and L-arginine on regional cerebral blood flow in the cat. J. Physiol., 449, 183-196.
16. MARTIN, W., WILLANI. G.M. & JOTHIANANDAN, D. (1985). Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and methylene blue in the rabbit aorta. J. Pharmacol. Exp. Ther., 232, 708-716.
17. MIYAGI, Y., KOBAYASHI. S., NISHIMURA, J., FUKUI, M. & KANAIDE, H. (1995a). Resting load regulates cytosolic calcium-force relationship of the contraction of bovine cerebrovascular smooth muscle. J. Physiol., 484, 123-137.
18. 2+ -insensitive mechanism. Am. J. Physiol., 268, C1332-C1341.
19. MONCADA, S. (1982). Prostaglandin and arterial wall biology. [Review] Arteriosclerosis, 2, 193-207.
20. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev., 43, 109-142.
21. 2U receptors in aortic endothelial cells. Circ. Res., 72, 504-510.
22. 2 purinoceptor that mediates prostacyclin production by pig aortic endothelial cells. Eur. J. Pharmacol., 134, 199-209.
23. NISHIMURA, J., KOLBER, M. & VAN BREEMEN C. (1988). Norepinephrine and GTP-γ-S increase myofilament calcium sensitivity in α-toxin permeabilized arterial smooth muscle. Biochem. Biophys. Res. Commun., 157, 677-683.
24. 2x-receptors in rabbit isolated ear artery. Br. J. Pharmacol., 101, 640-644.
25. O'CONNOR, S.E., DAINTY, I.A. & LEFF, P. (1991). Further subclassification of ATP receptors based on agonist studies. Trends Pharmacol. Sci., 12, 137-141.
26. RALEVIC, V. & BURNSTOCK, G. (1991). Effects of purines and pyrimidines on the rat mesenteric arterial bed. Circ. Res., 69, 1583-1590.
27. RAPOPORT, R.M. & MURAD, F. (1983). Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res., 52, 352-357.
28. RICHARDS, S.M., DORA. K.A., RATTIGAN, S., COLQUHOUN, E.Q. & CLARK, M.G. (1993). Role of extracellular UTP in the release of uracil from vasoconstricted hindlimb. Am. J. Physiol., 264, H233-H237.
29. SAJAG, B., MILON, D., SHACOORI, V., ALLAIN. H., RAULT, B., VAN DEN DRIESSCHE, J. (1992). Newly evidenced pyrimidinoceptors and the P2X purinoceptors are present on the vascular smooth muscle and respectively mediate the UTP- and ATP-induced contractions of the dog maximally internal vein. Res. Commun. Chem. Pathol. Pharmacol., 76, 89-94.
30. SHIRASAWA, Y., WHITE, R.P. & ROBERTSON, J.T. (1983). Mechanisms of the contractile effect induced by uridine 5-triphosphate in canine cerebral arteries. Stroke, 14, 347-355.
31. SOMLYO, A.P. & SOMLYO, A.V. (1994). Signal transduction and regulation in smooth muscle. Nature, 372, 231-236.
32. TAWADA, Y., FURUKAWA, K. & SHIGEKAWA, J. (1987). ATP-induced calcium transient in cultured rat aortic smooth muscle cells. J. Biochtm., 102, 1499-1509.
33. URQUILLA, P.R. (1978). Prolonged contraction of isolated human and canine cerebral arteries induced by uridine 5-triphosphate. Stroke, 9, 133-136.
34. USHIO-FUKAI. M., ABE, S., KOBAYASHI, S., NISHIMURA, J. & KANAIDE, H. (1993). Effects of isoprenaline on cytosolic calcium concentrations and on tension in the porcine coronary artery. J. Physiol., 462, 679-696.
35. 2 purinoceptor, in rabbit ear artery. Naunyn-Schmied Arch. Pharmacol., 336, 556-560.
36. 2x-receptor, in rabbit basilar artery: a receptor for pyrimidine nucleotides and a receptor for purine nucleotides. Naunyn-Schmied Arch. Pharmacol., 341, 538-546.
37. WHITE, R.P. & ROBERTSON, J.T. (1987). Pharmacodynamic evaluation of human cerebral arteries in the genesis of vasospasm. Neurosurgery, 21, 523-531.
38. 3H]-cyclopentyladenosine to adenosine A-1 receptors in rat brain membranes. J. Neurochem., 47, 88-97.