Quantitative analysis of multidrug resistance gene expression in human osteosarcomas

British Journal of Cancer

Volumn 74, Issue 7, 1996, Pages 1046-1050

  Lee, P D ^a,b   Noble Topham, S E ^b   Bell, R S ^a,b   Andrulis, I L ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

MDR1; Osteosarcoma; Quantitative reverse transcription polymerase chain reaction; Tumour heterogeneity; Tumour progression

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; MESSENGER RNA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; METASTASIS; MULTIDRUG RESISTANCE; OSTEOSARCOMA; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

EID: 0029744532     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.487     Document Type: Article

References (25)

1. AKIYAMA SI, FOJO A, HANOVER JA, HANOVER JA, PASTAN I AND GOTTESMAN MM. (1985). Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat. Cell. Mol. Genet., 11, 117-126.
2. BELL RS, BELL DF, O'CONNOR G AND JACOBS J. (1990). Effect of doxorubicin on local recurrence following marginal resection in the MGH-OGS murine model. J. Orthop. Res., 8, 105-118.
3. BORST P. (1991). Genetic mechanisms of drug resistance. Acta Ontol., 30, 87-105.
4. CAMPOS L, GUYOTAT D, ARCHIMBAUD E, CLAMARD-ORIOL P, TSURUO T, TRONCY J, TREILLE D AND FIERE D. (1992). Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood, 79, 473-476.
5. CHAN HS, THORNER PS, HADDAD G AND LING V. (1990). Immunohistochemical detection of p-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood. J. Clin. Oncol., 8, 689-704.
6. CHAN HS, HADDAD G, THORNER PS, DEBOER G, LIN YP ONDRUSEK N, YEGER H AND LING V. (1991). P-glycoprotein expression as a predictor of the outcome of therapy for neuroblastoma. N. Engl. J. Med., 325, 1608-1614.
7. CHAUDHARY PM AND RONINSON IB. (1993). Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs. J. Natl Cancer Inst., 85, 632-639.
8. CHOMCZYNSKI P AND SACCHI N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate phenol chloroform extraction. Anal. Biochem., 162, 156-159.
9. CHRETIEN S, DUBART A, BEUPAIN D, RAICH N, GRANDCHAMP B, ROSA J, GOOSSENS M AND ROMEO P-H. (1988). Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression. Proc. Natl Acad. Sci. USA, 85, 6-10.
10. ENDICOTT JA AND LING V. (1989). The biochemistry of p-glycoprotein-mediated multidrug resistance. Anna. Rev. Biochem., 58, 137-171.
11. FINKE J, ERITZEN R, TERNES P, LANGE W AND DOLKEN G. (1993). An improved strategy and a useful housekeeping gene for RNA analysis from formaline-fixed, paraffin-embedded tissues by PCR. Biotechnology, 14, 448-453.
12. GOLDSTEIN EJ, GALSKI H, FOJO A, WILLINGHAM M, LAI SL, GAZDAR A, PIRKER R, GREEN A, CRIST W, BRODEUR GM, LIEVER M, COSSMAN J, GOTTESMAN MM AND PASTAN I. (1989). Expression of a multidrug resistance gene in human cancers. J. Natl Cancer Inst., 81, 116-124.
13. GOTTESMAN MM AND PASTAN I. (1993). Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu. Rev. Biochem., 62, 385-427.
14. HOLZMAYER TA, HILSENBECK S, VON HOFF DD AND RONINSON IB. (1992). Clinical correlates of MDR1 (p-glycoprotein) gene expression in ovarian and small cell lung carcinomas. J. Natl Cancer Inst., 84, 1486-1491.
15. KANDEL RA, CAMPBELL S, NOBLE-TOPHAM S, BELL RS AND ANDRULIS IL. (1995). Correlation of p-glycoprotein detection by immunohistochemistry and polymerase chain reaction. Diagn. Mol. Pathol., 4, 59-65.
16. LIN RI AND SCHJEIDE OA. (1969). Micro estimation of RNA by the cupric ion catalyzed orcinol reaction. Anal. Biochem., 27, 473 483.
17. MARIE JP, ZITTOUN R AND SIKIC BI. (1993). Multidrug resistance (mdr 1) gene expression in adult acute leukemias correlations with treatment outcome in in vitro drug sensitivity. Blood, 78, 586-592.
18. MILLER TP, GROGAN TM, DALTON WS, SPIER CM, SCHEPER RJ AND SALMON SE. (1991). P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil. J. Clin. Oncol., 9, 17-24.
19. NOONAN KE, BECK C, HOLZMAYER TA, CHIN JE, WUNDER J, ANDRULIS IL, GAZDAR AF, WILLMAN CL, GRIFFITH B, VON HOFF DD AND RONINSON IB. (1990). Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction. Proc. Natl Acad. Sci. USA, 87, 7160-7164.
20. RAO VV, ANTHONY DC AND PIWNICA-WORMS D. (1994). MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res., 54, 1536-1541.
21. SAMBROOK J, FRITSCH EF AND MANIATIS T. (1989). Molecular Cloning: a Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY, USA.
22. SHEN DW, FOJO A, CHIN JE, RONINSON IB, RICHERT N, PASTAN I AND GOTTESMAN MM. (1986). Human multidrug-resistant cell lines: increased MDR1 expression can precede gene amplification. Science, 232, 643-645.
23. VERGIER B, CANY L, BONNET E, ROBERT J, DE MASCERAL A AND COINORE JM (1993). Expression of MDR1/PGP in human sarcomas. Br. J. Cancer, 68, 1221-1226.
24. WEINSTEIN RS, JAKATE SM, DOMINGUEZ JM, LEBOVITZ MD, KOUKOULIS GK, KUSZAK JR, KLUSENS LF, GROGAN TM, SACLARIDES TJ, RONINSON IB AND COON JS. (1991). Relationship of the expression of the multidrug resistance gene product (p-glycoprotein) in human colon carcinoma to local aggressiveness and lymph node metastasis. Cancer Res., 51, 2720-2726.
25. WUNDER JS, BELL RS, WOLD L AND ANDRULIS IL. (1993). Expression of the multidrug resistance gene in osteosarcoma. J. Orthop. Rex., 11, 396-403.