Effect of clonidine and yohimbine on sleep in healthy men: A double blind, randomized, controlled trial

European Journal of Clinical Pharmacology

Volumn 50, Issue 6, 1996, Pages 463-465

  Gentili, A ^a   Godschalk, M F ^a   Gheorghiu, D ^a   Nelson, K ^a   Julius, D A ^a   Mulligan, T ^a  

^a HUNTER HOLMES MCGUIRE VA MEDICAL CENTER   (United States)

Author keywords

2 adrenoceptors; Clonidine; Man; REM sleep; Yohimbine

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; PLACEBO; YOHIMBINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP; SLEEP;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; CLONIDINE; DOUBLE-BLIND METHOD; HUMANS; MALE; MIDDLE AGED; SLEEP, REM; YOHIMBINE;

EID: 0029744266     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050141     Document Type: Article

References (24)

1. 2-adrenoceptor affect sleep and arousal mechanisms. Br J Pharmacol 90:675-685
2. Putkonen PTS, Leppavuori A, Stenberg D (1977) Paradoxical sleep inhibition by central alpha-adrenoceptor stimulant clonidine antagonized by alpha-receptor blocker yohimbine. Life Sci 21:1059-1066
3. 2-adrenergic agonist clonidine in the dorsal pontine tegmentum of the cat. Pflugers Arch 418:512-518
4. Autret A, Minz M, Beillevaire T, Cathala HP, Schmitt H (1977) Effect of clonidine on sleep patterns in man. Eur J Clin Pharmacol 12:319-322
5. Gaillard JM, Kufi S (1979) Involvement of pre- and postsynaptic receptors in catecholaminergic control of paradoxical sleep in man. Eur J Clin Pharmacol 15:83-89
6. Kanno O, Clarenbach P (1985) Effect of clonidine and yohimbine on sleep in man: Polygraphic and EEG analysis by normalized slope descriptors. Electroencephalogr Clin Neurophysiol 60:478-484
7. Spiegel R, Devos JR (1985) Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects. Br J Clin Pharmacol 10:165S-168S
8. - ceptor function and sleep in man: studies with clonidine and idazoxan. Neuropharmacology 30:367-372
9. Kerkhofs M, Linkowski P, Mendlewiez J (1989) Effect of intravenous catheter on sleep in healthy men and depressed patients. Sleep 12:113-119
10. Brown MJ, Harland D, Murphy MB, Smithers AD (1984) Effect of centrally acting α-adrenegic agonists on sympathetic nervous system function in humans. Hypertension 6 (Suppl II):57-62
11. Svensson TH, Bunney BS, Aghajanian (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Res 92:291-306
12. Yoshioka M, Matsumoto M, Togashi H, Smith CB, Saito M (1992) Alpha-2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain. Neurosci. Lett. 139:53-56
13. Davies DS, Wing LMH, Reid DM, Neill E, Tippett P, Dollery MB (1977) Pharmacokinetics and concentration effect relationships of intravenous and oral clonidine. Clin Pharmacol Ther 21:593-601
14. Gaillard JM, Iorio G, Kafi S, Blois R (1983) Paradoxical sleep rebound without previous debt: The effect of minute doses of clonidine in man. Sleep 61:60-66
15. 2-adrenoreceptor. Pharmacol Rev 35:143-180
16. 1A receptors. Eur J Pharmacol 199:263-265
17. Kafi S, Gaillard M (1980) The effect of presynaptic alpha blocker yohimbine on rat paradoxical sleep. Waking Sleeping 4:131-137
18. Bier MJ, McCarley RW (1994) REM-enhancing effects of the adrenergic antagonist idazoxan infused into the medial pontine reticular formation of the freely moving cat. Brain Res 634:333-338
19. Grossman E, Rea RF, Hoffman A, Goldstein DS (1991) Yohimbine increases sympathetic nerve activity and norepinephrine spillover in normal volunteers. Am J Physiol 260: R142-R147
20. Bricca G, Dontenwill M, Molines A, Feldman J, Belcourt A, Bousquet P (1988) Evidence for the existence of a homogeneous population of imidazoline receptors in the human brainstem. Eur J Pharmacol 150:401-402
21. 2-adrenergic receptors in the rostral ventrolateral medulla. J Hypert 6: S554-S557
22. 2-Adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol 99: 803-809
23. Bousquet P, Feldman J, Tibirica E, Bricca G, Greney H, Dontenwill M, Stutzmann J, Belcourt A (1992) Imidazoline receptors. A new concept in central regulation of the arterial blood pressure. Am J Hypertens 5 (4 Pt 2):47S-50S
24. Fillastre JP, Letac B, Galinier F, Le Bihan G, Schwartz J (1988) A multi center double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients. Am J Cardiol 61:81D-85D