Effects of nilvadipine (a dihydropyridine-type calcium entry blocker) on cerebral blood flow in acute experimental brain ischemia in rats

Neurological Research

Volumn 18, Issue 4, 1996, Pages 325-328

  Tanaka, Ryusui ^a   Miyasaka, Yoshio ^a   Maruyama, Sigeyoshi ^a   Nagai, Shigeki ^a   Fujii, Kiyotaka ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium entry blocker; cerebral blood flow; experimental ischemia; nilvadipine; rat

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; NILVADIPINE;

ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG INFUSION; INTRAARTERIAL DRUG ADMINISTRATION; NONHUMAN; RAT;

EID: 0029743006     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1996.11740430     Document Type: Article

References (23)

1. Agnoli A, Fieschi C, Bozzao L, Battistini N, Prencipe M. Autoregulation of cerebral blood flow - studies during drug-induced hypertension in normal subjects and in patients with cerebral vascular diseases. Circulation 1968; 38: 800-812
2. Paulson OB. Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery. Neurology 1970; 20: 63-77
3. 2 on hyperemia and ischemia in experimental cerebral infarction. Stroke 1971; 2: 139-147
4. Bogousslavsky J, Regli F, Zumstein V, Kobberling W. Double-blind study of nimodipine in non-severe stroke. Eur Neurol 1990; 30: 23-26
5. Gelmers HJ, Gorter K, Weerdt CJ, Wiezer HJA. A controlled trial of nimodipine in acute ischemic stroke. N Engl J Med 1988; 381: 203-207
6. Paci A, Ottaviano P, Trenta A, Iannone G, De Santis L, Lancia G, Moschini E, Carosi M, Amigoni S, Caresia L. Nimodipine in acute ischemic stroke: a double-blind controlled study. Acta Neurol Scand 1989; 80: 282-286
7. Rosenbaum DM, Grotta JC, Yatsu FM, Picone CM, Pettigrew LC, Bratina P, Zabramski J, Spetzler R, Lopez L, Marler J, Ellis D. Pilot study of nicardipine for acute ischemic stroke. Angiology 1990; 41: 1017-1022
8. Rosenbaum D, Zabramski J, Frey J, Yatsu F, Marler J, Spetzler R, Grotta J. Early treatment of ischemic stroke with a calcium antagonist. Stroke 1991; 22: 437-441
9. The American Nimodipine Study Group. Clinical trial of nimodipine in acute ischemic stroke. Stroke 1992; 23: 3-8
10. Trust Study Group. Randomised, double-blind, placebo-controlled trial of nimodipine in acute stroke. Lancet 1990; 336: 1205-1209
11. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski HM. Rat middle cerebral artery occlusion: Evaluation of a neurologic examination. Stroke 1986; 17: 472-476
12. Tamura A, Graham DI, McCulloch J, Teasdale GM. Focal cerebral ischemia in the rat: I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1981; 1: 53-60
13. Tanaka R, Miyasaka Y, Yada K, Ohwada T, Kameya T. Basic fibroblast growth factor increases regional cerebral blood flow and reduces infarct size after experimental ischemia in a rat model. Stroke 1995; 26: 2154-2159
14. Harper AM, Craigen L, Kazda S. Effect of the calcium antagonist, nimodipine, on cerebral blood flow and metabolism in the primate. J Cereb Blood Flow Metab 1981; 1: 349-356
15. Mohamed AA, McCulloch J, Mendelow AD, Teasdale GM, Harper AM. Effect of calcium antagonist nimodipine on local cerebral blood flow: relationship to arterial blood pressure. J Cereb Blood Flow Metab 1984; 4: 206-211
16. Mohamed AA, Mendelow AD, Teasdale GM, Harper AM, McCulloch J. Effect of calcium antagonist nimodipine on local cerebral blood flow and metabolic coupling. J Cereb Blood Flow Metab 1985; 5: 26-33
17. Gelmers HJ. The effects of nimodipine on the clinical course of patients with acute ischemic stroke. Acta Neurol Scand 1984; 69: 232-239
18. Grotta JC, Pettigrew LC, Rosenbaum D, Reid C, Rhoades H, McCandless D. Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats. Stroke 1988; 19: 447-454
19. Mohamed AA, Gotoh O, Graham DI, Osborne KA, McCulloch J, Mendelow AD, Teasdale GM, Harper AM. Effect of pretreatment with the calcium antagonist nimodipine on local cerebral blood flow and histopathology after middle cerebral artery occlusion. Ann Neurol 1985; 18: 705-711
20. Ohtaki M, Tranmer B. Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877. Stroke 1994; 25: 1234-1240
21. Faden AI, Jacobs TP, Smith MT. Evaluation of the calcium channel antagonist nimodipine in experimental spinal cord ischemia J Neurosurg 1984; 60: 796-799
22. McCalden TA, Nath RD, Thiele K. The effects of a calcium antagonist (nimodipine) on basal cerebral blood flow and reactivity to various agonists. Stroke 1984; 15: 527-530
23. Hoedt-Rasmussen K, Skinhoj E, Paulson O, Ewald J, Bjerrum JK, Fahrenkrug A, Lassen A. Regional cerebral blood flow in acute apoplexy - The 'luxury perfusion syndrome' of brain tissue. Arch Neurol 1967; 17: 271-281