Glutathione and glutathione redox cycle in riboflavin supplemented cataractous rat lenses

Indian Journal of Pharmacology

Volumn 28, Issue 2, 1996, Pages 93-97

  Vani, R R ^a   Rawal, U M ^a  

^a GUJARAT UNIVERSITY   (India)

Author keywords

cataract; glutathione; Riboflavin; sodium selenite

Indexed keywords

GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; RIBOFLAVIN; SELENITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATARACT; DRUG EFFECT; ENZYME ACTIVITY; ENZYME REGULATION; GLUTATHIONE METABOLISM; NONHUMAN; OXIDATION REDUCTION REACTION; RAT;

EID: 0029742756     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Balasubramanian D, Bhat KS, Rao GN. Factors in the prevalence of cataract in India-analysis of the recent Indo-US study of are- related cataracts. Current Sci 1990; 59:498-505.
2. Rathbun WB, Bovis MG. Activity of glutathione peroxidase and glutathione reductase in the human lens related to age. Curr Eye Res 1986;5:381-5.
3. Graw J, Summer KH, Michel C, Boss W. Catalase and superoxide dismutase activities in lenses of cataractous NOP-mice. Exp Eye Res 1985;41:577-9.
4. Beutler E. Glutathione reductase: Stimulation in normal subjects by riboflavin supplementation. Sci 1969;165:612-5.
5. Bhat KS. Bulletin of the Nutrition Foundation of India 1993;14:1-3.
6. Bhuyan KC, Bhuyan DK, Podos SM. Cataract by selenium in rat: Effect of lenticular proteins and thiols. IRCS Medical Science: Biochemistry; Drug metabolism and toxicology: Environmental Biology and Medicine, The Eye; Pathology and Pharmacology 1981;9:194.
7. Vani RR, Rawal UM. A biochemical study on the effect of riboflavin on cataractous rat lenses. II protein and glutathione. Ind J Clin Biochem 1994;9:96-7.
8. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with folin-phenol reagent. J Biol Chem 1951;193:265-75.
9. Ellman GL. Tissue sulfhydryl groups Arch Biochem Biophys 1959;82:70-7.
10. Fiske CH, Subba Row Y. The colorimetric determination of phosphorous. J Biol Chem 1925;66:375.
11. Rathbun W. γ-gtutamylcysteine synthetic from bovine lens. I purification and properties. Arch Biochem Biophys 1967;122:62.
12. Carlberg I, Mannervik B. Glutathione reductase. In: Meister A, ed. Methods in enzymology. Academic Press Inc., 1984;113:484-90.
13. Pagila DE, Valentine WN. Studies on the quantitative and qualitative characterisation of erythrocyte glutathione peroxidase. J Lab Clin Med 1967;70:158-69.
14. Shearer TR, David LL, Anderson RJ, Azuma M. Review of selenite cataract. Curr Eye Res 1992;11:357-69.
15. Reddy VN, Giblin FJ, Matsuda H. Defense system of the lens against oxidative damage. In: Srivastava, ed. Red Blood Cell and Lens metabolism. 1980:139-54.
16. Reddy VN. Metabolism of glutathione in the lens. Exp Eye Res 1971;11:310-28.
17. Bhat KS, John A, Reddy PR, Reddy PS, Reddy VN. Effect of pigmentation on glutathione redox cycle antioxidant defense in whole as well as different region on human cataractous lens. Exp Eye Res 1991;52:715-21.
18. Vani RR, Rawal UM. Riboflavin and cataract reversal. In: Gupta SK, Biswas SR, eds. Current trends in ocular pharmacology. New Delhi: AIIMS Press, 1994:32-6.
19. Augusteyn RC. Protein modification in cataract: Possible oxidative mechanisms. In: Duncan G, ed. Mechanisms of cataract formation. Academic Press, 1981:70-115.