Sympatholytic and minimum anesthetic concentration-sparing responses are preserved in rats rendered tolerant to the hypnotic and analgesic action of dexmedetomidine, a selective α2-adrenergic agonist

Anesthesiology

Volumn 85, Issue 3, 1996, Pages 565-573

  Rabin, Bradford C ^a   Reid, Kristina ^b   Guo, Tian Zhi ^b   Gustafsson, Eva ^b   Zhang, Chousheng ^b   Maze, Mervyn ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Brain: hippocampus; locus coeruleus; Receptors: 2 adrenoceptor; Sympathetic nervous system, catecholamines: norepinephrine; Sympathetic nervous system, 2 adrenergic agonists: dexmedetomidine; Treatment: chronic

Indexed keywords

ARTICLE; CATECHOLAMINE METABOLISM; CONTROLLED STUDY; DRUG RESPONSE; DRUG TOLERANCE; HIPPOCAMPUS; INHALATIONAL DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; LOCUS CERULEUS; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; SYMPATHETIC BLOCKING;

EID: 0029742436     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199609000-00016     Document Type: Article

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