Oligospermia improved by switching an anticonvulsant from phenytoin to valproate

Clinical Neurology

Volumn 36, Issue 3, 1996, Pages 492-494

  Niwa, Kiyoshi ^a   Kitagawa, Yasuhisa ^a   Yoshii, Fumihito ^b   Shinohara, Yukito ^b  

^a TOKAI UNIVERSITY OISO HOSPITAL   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

epilepsy; oligospermia; phenytoin; valproate

Indexed keywords

PHENYTOIN; VALPROIC ACID;

ADULT; ANTICONVULSANT THERAPY; ARTICLE; CASE REPORT; DRUG EFFECT; HUMAN; MALE; OLIGOSPERMIA; SEIZURE; SEMEN ANALYSIS; SPERMATOZOON COUNT;

ADULT; ANTICONVULSANTS; HUMANS; MALE; OLIGOSPERMIA; PHENYTOIN; VALPROIC ACID;

EID: 0029742089     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (4)

1. Chen SS, Shen MR, Chen TJ, et al: Effects of antiepileptic drugs on sperm motility of normal controls and epileptic patients with long-term therapy. Epilepsia 33: 149-153, 1992
2. Taneja N, Kucheria K, Jain S, et al: Effect of phenytoin on semen. Epilepsia 35: 136-140, 1994
3. Swanson BN, Leger RM, Gordon WP, Lynn RK, et al: Excretion of phenytoin into semen of rabbits and man: Comparison with plasma levels. Drug Metab Disp 6: 70-74, 1978
4. Cohn DF, Homonnai ZT, Paz GF: The effect of anticonvulsant drugs on the development of male rats and their fertility. J Neurol Neurosurg Psychiatry 45: 844-846, 1982