Involvement of 5-HT(1D) receptors in cortical extracellular 5-HT release in guinea-pigs on exposure to the elevated plus maze

Journal of Psychopharmacology

Volumn 10, Issue 3, 1996, Pages 219-224

  Rex, A ^a,b   Fink, H ^b   Skingle, M ^c   Marsden, C A ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b HUMBOLDT UNIVERSITY   (Germany)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT; 5 HT(1D) antagonist; Aversion; GR 127935; Guinea pig; X maze

Indexed keywords

5 CARBAMOYLTRYPTAMINE; AUTORECEPTOR; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN; SEROTONIN 1D RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BRAIN CORTEX; CONTROLLED STUDY; ENVIRONMENT; FEMALE; FRONTAL CORTEX; GUINEA PIG; INTRAPERITONEAL DRUG ADMINISTRATION; MAZE TEST; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; SEROTONIN RELEASE;

EID: 0029741848     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988119601000307     Document Type: Article

References (32)

1. Barth T, Rex A, Domeney A M, Fink H (1993) Effects of cholecystokinin fragments in three animal models of anxiety. In Elsner N, Heisenberg M (eds), Gene - Brain - Behaviour. Georg Thieme Verlag, Stuttgart, New York, p. 621
2. 2 receptor sensitivity in the rat. Eur J Pharmacol 231: 395-406
3. Blanchard R J, Yudko E B, Blanchard D C, Taukulis H K (1993) High-frequency (35-70 kHz) ultrasonic vocalizations in rats confronted with anesthetized conspecifics: effects of gepirone, ethanol, and diazepam. Pharmacol Biochem Behav 44: 313-319
4. Carboni E, Di Chiara G (1989) Serotonin release estimated by transcortical dialysis in freely moving rats. Neuroscience 32: 637-646
5. Chopin P, Briley M (1987) Animal models of anxiety: the effect of compounds that modify 5-HT neurotransmission. Trends Pharmacol Sci 8: 383-388
6. 1D receptor sites. Naunyn-Schmiedeberg's Arch Pharmacol 347: 248-256
7. Glennon R A (1990) Serotonin receptors: clinical implications. Neurosci Biobehav Rev 14: 35-47
8. Graeff F G, Schoenfeld R I (1970) Tryptamine mechanism in punished and nonpunished behaviour. J Pharmacol Exp Ther 173: 277-283
9. Handley S L, Mithani S (1984) Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of "fear"-motivated behaviour. Naunyn-Schmiedeberg's Arch Pharmacol 327: 1-5
10. Hoyer D, Middlemiss D N (1989) Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. Trends Pharmacol Sci 10: 130-132
11. Hoyer D, Clarke D E, Fozard J R, Hartig P R, Martin G R, Mylecharane E J, Saxena P R, Humphrey P P A (1994) VII. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46: 157-203
12. Humphrey P P A, Harting P, Hoyer D (1993) A proposed new nomenclature for 5-HT receptors. Trends Pharmacol Sci 141: 233-236
13. 1D receptor antagonist, on brain 5-HT metabolism, extracellular 5-HT concentration and behaviour in the guinea pig. Neuropharmacology 34: 383-392
14. 1B receptor. J Biol Chem 267: 5735-6738
15. Lawrence A J, Marsden C A (1992) Terminal autoreceptor control of 5-hydroxytryptamine as measured by in vivo microdialysis in the conscious guinea-pig. J Neurochem 58: 142-146
16. 1E binding sites in human brain. Eur J Pharmacol 222: 137-142
17. 1D alpha receptor sites. Neuropharmacology 34: 335-237
18. Pellow S, Chopin P, File S E, Briley M (1985) Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14: 149-167
19. Price G W, Watson J, Roberts C, Jones B J (1993) Multiple 5-HT autoreceptors in guinea-pig cerebral cortex demonstrated by in vitro [3H]5-HT release. Br J Pharmacol 100: 101
20. Rex A, Marsden C A, Fink H (1993a) Effect of diazepam on cortical 5-HT release and behaviour in the guinea-pig on exposure to the elevated plus maze. Psychopharmacology 110: 490-496
21. 1A receptors and changes in extracellular 5-HT in the guinea-pig prefrontal cortex: involvement in aversive behaviour. J Psychopharmacol 7(4): 338-345
22. Rex A, Marsden C A, Fink H (1994) 5-HT-CCK interactions in anxiety-related behaviour studied using microdialysis. In Loilout A, Durkin T, Spampinato U, Cador M (eds), Monitoring molecules in neurosciences. Bordeaux, pp. 221-222
23. Roberts C, Watson J, Price G W, Jones B J (1994) Regional differences in the guinea-pig terminal 5-HT autoreceptor. Br J Pharmacol 112: 301
24. Rössner W (1965) Stereotaktischer Hirnatlas vom Meerschweinchen. Pallas Verlag, Lochham
25. 1A receptor ligands in animal models of anxiety, impulsivity and depression: multiple mechanisms of action? Prog Neuropsychopharmacol Biol Psychiatr 17: 87-104
26. Sharp T, Bramwell S R, Hjorth S, Grahame-Smith D G (1989) Pharmacological characterization of 8-OH-DPAT-induced inhibition of rat hippocampal 5-HT release in vivo as measured by microdialysis. Br J Pharmacol 98: 989-997
27. 1D receptor antagonist. Br J Pharmacol 110: 9
28. 1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis. Neuropharmacology 34: 377-382
29. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphé nucleus. Neuropharraacology 33: 393-394
30. 1D receptors in guinea pig and pigeon brain. Radioligand binding and biochemical studies. Naunyn-Schmiedeberg's Arch Pharmacol 340: 486-494
31. Wise C D, Berger B D, Stein L (1972) Benzodiazepines: anxiety-reducing activity by reduction of serotonin turnover in the rat brain. Science 177: 180-183
32. Wright I K, Upton N, Marsden C A (1992) Effect of established and putative anxiolytics on extracellular 5-HT and 5-HIAA in the ventral hippocampus of rats during behaviour on the elevated X-maze. Psychopharmacology 109: 338-346