Heat shock protein-peptide complexes for use in vaccines

Journal of Leukocyte Biology

Volumn 60, Issue 2, 1996, Pages 153-158

  Heike, Michael ^a   Noll, Bernhard ^a   Meyer Zum Büschenfelde, Karl Hermann ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Antigen presentation; gp96; HSP70; HSP90; T cells; Tumor immunology

Indexed keywords

CANCER VACCINE; CHAPERONE; GLYCOPROTEIN 96; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; PEPTIDE; UNCLASSIFIED DRUG;

ANTIGEN PRESENTATION; HUMAN; IMMUNIZATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; TUMOR IMMUNITY;

EID: 0029741634     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.60.2.153     Document Type: Review

References (75)

1. Srivastava, P.K., DeLeo, A., Old, L.J. (1986) Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc. Natl. Acad. Sci. USA 83, 3407-3411.
2. Ullrich, S.J., Robinson, E.A., Law, L.W., Willingham, M., Appella, E. (1986) A mouse tumor-specific transplantation antigen is a heat shock-related protein. Proc. Natl. Acad. Sci. USA 83, 3121-3125.
3. Moore, S.K., Kozak, C., Robinson, E.A., Ullrich, S.J., Appella, E. (1987) Cloning and nucleotide sequence of the murine hsp84 cDNA and chromosome assignment of related sequences. Gene 56, 29-40.
4. Maki, R.G., Old, L.J., Srivastava, P.K. (1990) Human homologue of murine tumor rejection antigen gp96: 5′-regulatory and coding regions and relationship to stress-induced proteins. Proc. Natl. Acad. Sci. USA 87, 5658-5662.
5. Udono, H., Srivastava, P.K. (1993) Heat shock protein 70-associated peptides elicit specific cancer immunity. J. Exp. Med. 178, 1391-1396.
6. Blachere, N.E., Udono, H., Janetzki, S., Li, Z., Heike, M., Srivastava, P.K. (1993) Heat shock protein vaccines against cancer. J. Immunother. 14, 352-356.
7. Udono, H., Srivastava, P.K. (1994) Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70. J. Immunol. 152, 5398-5403.
8. Srivastava, P.K., Chen, Y.-T., Old, L.J. (1987) 5′-structural analysis of genes encoding polymorphic antigens of chemically induced tumors. Proc. Natl. Acad. Sci. USA 84, 3807-3811.
9. Moore, S.K., Rijli, F., Appella, E. (1990) Characterization of the mouse 84-kD heat shack protein gene family. DNA Cell Biol. 9, 387-400.
10. Maki, R.G., Eddy, R.L., Jr., Byers, M., Shows, T.B., Srivastava, P.K. (1993) Mapping of the genes for human endoplasmic reticular heat shock protein gp96/grp94. Somat. Cell Mol. Genet. 19, 73-81.
11. Srivastava, P.K., Heike, M. (1991) Tumor-specific immunogenicity of stress-induced proteins: convergence of two evolutionary pathways of antigen presentation? Semin. Immunol. 3, 57-64.
12. Welch, W., Kang, H., Beckmann, R., Mizzen, L. (1991) Changes in cell physiology and structure/function of stress proteins. Curr. Top. Microbiol. Immunol. 167, 31-55.
13. Hendrick, J.P., Hartl, F.-U. (1993) Molecular chaperone functions of heat-shock proteins. Annu. Rev. Biochem. 62, 349-384.
14. Craig, E.A., Weissman, J.S., Horwich, A.L. (1994) Heat shock proteins and molecular chaperones: mediators of protein conformation and turnover in the cell. Cell 78, 365-372.
15. Mazzarella, R.A., Green, M. (1987) ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (CRP94). J. Biol. Chem. 262, 8875-8883.
16. Lee, A. (1987) Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biol. Sci. 12, 20-23.
17. Kozutsumi, Y., Segal, M., Normington, K., Gething, M.-J., Sambrook, J. (1988) The presence of malfolded proteins in the endoplasmatic reticulum signals the induction of glucose-regulated proteins. Nature 332, 462-464.
18. Booth, C., Koch, L. (1989) Perturbation of cellular calcium induces secretion of luminal ER proteins. Cell 59, 729-737.
19. Li, Z., Srivastava, P.K. (1993) Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentation. EMBO J. 12, 3143-3151.
20. Navarro, D., Qadri, I., Pereira, L. (1991) A mutation in the ectodomain of herpes simplex virus 1 glycoprotein B causes defective processing and retention in the endoplasmic reticulum. Virology 184, 253-264.
21. Schaiff, W.T., Hruska, K.A., Jr., McCourt, D.W., Green, M., Schwartz, B.D. (1992) HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells. J. Exp. Med. 176, 657-666.
22. Williams, D.B., Watts, T.H. (1995) Molecular chaperones in antigen presentation. Curr. Opin. Immunol. 7, 77-84.
23. Melnick, J., Aviel, S., Argon, Y. (1992) The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains. J. Biol. Chem. 267, 21303-21306.
24. Melnick, J., Dul, J.L., Argon, Y. (1994) Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature 370, 373-375.
25. Melnick, J., Argon, Y. (1995) Molecular chaperones and the biosynthesis of antigen receptors. Immunol Today 16, 243-250.
26. Srivastava, P.K., Udono, H. (1994) Heat shock protein-peptide complexes in cancer immunotherapy. Curr. Opin. Immunol. 6, 728-732.
27. Suto, R., Srivastava, P.K. (1995) A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides. Science 269, 1585-1588.
28. Srivastava, P.K., Udono, H., Blachere, N.E., Li, Z. (1994) Heat shock proteins transfer peptides during antigen processing and CTL priming. Immunogenetics 39, 93-98.
29. Arnold, D., Faath, S., Rammensee, H.-G., Schild, H. (1995) Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96. J. Exp. Med. 182, 885-889.
30. Bevan, M.J. (1976) Cross-priming for a secondary cytotoxic response Io minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxicity assay. J. Exp. Med. 143, 1283-1288.
31. Gooding, L.R., Edwards, C.B. (1980) H-2 antigen requirements in the in vitro induction of SV40-specific cytotoxic T lymphocytes. J. Immunol. 124, 1258-1262.
32. Srivastava, P.K., Maki, R.G., Zhao, J.Q., Chang, T.J., Heike, M. (1990) Immunization with soluble gp96 antigens elicits tumor-specific T cell immunity. UCLA Symposia New Series 135, 307-314.
33. + T cells in vivo. Proc. Natl. Acad. Sci. USA 91, 3077-3081.
34. Lakey, E.K., Margoliash, E., Pierce, S.K. (1987) Identification of a peptide binding protein that plays a role in antigen presentation. Proc. Natl. Acad. Sci. USA 84, 1659-1663.
35. Vanbuskirk, A., Crump, B.L., Margoliash, E., Pierce, S.K. (1989) A peptide binding protein having a role in antigen presentation is a member of the HSP70 heat shock family. J. Exp. Med. 170, 1799-1809.
36. VanBuskirk, A.M., DeNagel, D.C., Guagliardi, L.E., Brodsky, F.M., Pierce, S.K. (1991) Cellular and subcellular distribution of PBP72/74, a peptide-binding protein that plays a role in antigen processing. J. Immunol. 146, 500-506.
37. Domanico, S.Z., DeNagel, D.C., Dahlseid, J.N., Green, J.M., Pierre, S.K. (1993) Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family. Mol. Cell. Biol. 13, 3598-3610.
38. Clairmont, C.A., De Maio, A.D., Hirschberg, C.B. (1992) Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP78) and GRP94. J. Biol. Chem. 267, 3983-3990.
39. + but not ATP hydrolysis. Nature 365, 664-666.
40. Frydman, J., Nimmesgern, E., Ohtsuka, K., Hartl, U. (1994) Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones. Nature 370, 111-117.
41. Kang, P.J., Ostermann, J., Shilling, J., Neupert, W., Craig, E.A., Pfanner, N. (1990) Requirement for hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature 348, 137-143.
42. Beckmann, R.P., Mizzen, L.E., Welch, W.J. (1990) Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 248, 850-854.
43. Beckmann, R.P., Lovett, M., Welch, W.J. (1992) Examining the function and regulation of hsp 70 in cells subjected to metabolic stress. J. Cell Biol. 117, 1137-1150.
44. de Silva, A., Braakman, I., Helenius, A. (1993) Posttranslational folding of vesicular stomatitis virus G protein in the ER: involvement of noncovalent and covalent complexes. J. Cell Biol. 120, 647-655.
45. Hammond, C., Helenius, A. (1994) Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus. J. Cell Biol. 126, 41-52.
46. Rippmann, F., Taylor, W.R., Rothbard, J.B., Green, N.M. (1991) A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA. EMBO J. 10, 1053-1059.
47. Landry, S.J., Jordan, R., McMacken, R., Gierasch, L.M. (1992) Different conformations for the same polypeptide bound to chaperones DnaK and CroEL. Nature 355, 455-457.
48. Flynn, C.C., Pohl, J., Flocco, M.T., Rothman, J.E. (1991) Peptide-binding specificity of the molecular chaperone BiP. Nature 353, 726-730.
49. Blond Elguindi, S., Cwirla, S.E., Dower, W.J., Lipshutz, R.J., Sprang, S.R., Sambrook, J.F., Gething, M.J. (1993) Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP. Cell 75, 717-728.
50. Halevy, O., Michalovitz, D., Oren, M. (1990) Different tumor-derived p53 mutants exhibit distinct biological activities. Science 250, 113-116.
51. Hinds, P.W., Finlay, C.A., Quartin, R.S., Baker, S.J., Fearon, E.R., Vogelstein, B., Levine, A.J. (1990) Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes. Cell Growth Diff. 1, 571-580.
52. Lim, M.Y., Davis, N., Zhang, J.Y., Bose, H.R., Jr. (1990) The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70. Virology 175, 149-160.
53. Jindal, S., Young, R.A. (1992) Vaccinia virus infection induces a stress response that leads to association of Hsp70 with viral proteins. J. Virol. 66, 5357-5362.
54. DeNagel, D.C., Pierce, S.K. (1992) A case for chaperones in antigen processing. Immunol. Today 13, 86-89.
55. Schirmbeck, R., Reimann, J. (1994) Peptide transporter independent, stress protein-mediated endosomal processing of endogenous protein antigens for major histocompatibility complex class 1 presentation. Eur. J. Immunol. 24, 1478-1486.
56. Kim, H.T., Nelson, E.L., Clayberger, C., Sanjanwala, M., Sklar, J., Krensky, A.M. (1995) Gamma delta T cell recognition of tumor Ig peptide. J. Immunol. 154, 1614-1623.
57. Tamura, Y., Tsuboi, N., Sato, N., Kikuchi, K. (1993) 70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity. J. Immunol. 151, 5516-5524.
58. Barrios, C., Lussow, A.R., Van Embden, J., Van der Zee, R., Rappuoli, R., Costantino, P., Louis, J.A., Lambert, P.H., Del Giudice, G. (1992) Mycobacterial heat-shock proteins as carrier molecules. II: The use of the 70-kDa mycobacterial heat-shock protein as carrier for conjugated vaccines can circumvent the need for adjuvants and Bacillus Calmette Guerin priming. Eur. J. Immunol. 22, 1365-1372.
59. Davidoff, A.M., Iglehart, J.D., Marks, J.R. (1992) Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers. Proc. Natl. Acad. Sci. USA 89, 3439-3442.
60. Menoret, A., Patry, Y., Burg, C., Le Pendu, J. (1995) Co-segregation of tumor immunogenicity with expression of inducible but not constitutive hsp70 in rat colon carcinomas. J. Immunol. 155, 740-747.
61. Nathan, D.F., Lindquist, S. (1995) Mutational analysis of Hsp90 function: interactions with a steroid receptor and a protein kinase. Mol. Cell Biol. 15, 3917-3925.
62. Wiech, H., Buchner, J., Zimmermann, R., Jakob, U. (1992) Hsp90 chaperones protein folding in vitro. Nature 358, 169-170.
63. Nadeau, K., Das, A., Walsh, C.T. (1993) Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. J. Biol. Chem. 268, 1479-1487.
64. Kellermayer, M.S., Csermely, P. (1995) ATP induces dissociation of the 90 kDa heat shock protein (hsp90) from F-actin: interference with the binding of heavy meromyosin. Biochem. Biophys. Res. Commun. 211, 166-174.
65. Bevan, M.J. (1995) Antigen presentation to cytotoxic T lymphocytes in vivo. J. Exp. Med. 182, 639-641.
66. Houghton, A. (1994) Cancer antigens: immune recognition of self and altered self. J. Exp. Med. 180, 1-4.
67. Pardoll, D.M. (1994) Tumour antigens. A new look for the 1990s. Nature 369, 357-358.
68. Rock, K.L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., Goldberg, A.L. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771.
69. Fuller, K.J., Issels, R.D., Slosman, D.O., Guillet, J.G., Soussi, T., Polla, B.S. (1994) Cancer and the heat shock response. Eur. J. Cancer 30A, 1884-1891
70. Ferrarini, M., Heltai, S., Zocchi, M.R., Rugarli, C. (1992) Unusual expression and localization of heat-shock proteins in human tumor cells. Int. J. Cancer 51, 613-619.
71. Gress, T.M., Müller-Pilasch, F., Weber, C., Lerch, M., Friess, H., Büchler, M., Beger, H.G., Adler, G. (1994) Differential expression of heat shock protein in pancreatic carcinoma. Cancer Res. 54, 547-551.
72. Jameel, A., Skilton, R.A., Campbell, T.A., Chander, S.K., Coombes, R.C., Luqmani, Y.A. (1992) Clinical and biological significance of HSP89 alpha in human breast cancer. Int. J. Cancer 50, 409-415.
73. Multhoff, G., Botzler, C., Wiesnet, M., Muller, R., Meier, T., Wilmanns, W., Issels, R.D. (1995) A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells. Int. J. Cancer 61, 272-279.
74. Wölfel, T., Klehman, E., Müller, C., Schütt, K.-H., Meyer zum Büschenfelde, K.-H., Knuth, A. (1989) Lysis of human melanoma cells by autologous cytolytic: T cell clones. J. Exp. Med. 170, 797-810.
75. INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science 269, 1281-1284.