Synthesis and tryptic hydrolysis of p-guanidinophenyl esters derived from amino acids and peptides

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 8, 1996, Pages 1577-1579

  Sekizaki, Haruo ^a   Itoh, Kunihiko ^a   Toyota, Eiko ^a   Tanizawa, Kazutaka ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

Author keywords

enzyme kinetics; inverse substrate; N( ) (tert butyloxycarbonyl)amino acid p guanidinophenyl ester; N( ) (tert butyloxycarbonyl)peptide p guanidinophenyl ester; trypsin; tryptic hydrolysis

Indexed keywords

DEXTRO AMINO ACID; ESTER DERIVATIVE; GUANIDINE DERIVATIVE; TRYPSIN;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; SYNTHESIS;

EID: 0029741053     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.1577     Document Type: Article

References (18)

1. The following abbreviations are used: BOC = tert-butyloxycarbonyl, Z = benzyloxycarbonyl, DCC = N,N′-dicyclohexylcarbodiimide, DMF = N,N-dimethylformamide, DCUrea = dicyclohexylurea, DMAP = 4-dimethylaminopyridine, Gp = p-guanidinophenyl.
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