Effect of ranitidine on renal clearance of lomefloxacin

European Journal of Clinical Pharmacology

Volumn 51, Issue 1, 1996, Pages 95-98

  Sudoh, T ^a   Fujimura, A ^a   Harada, K ^a   Sunaga, K ^a   Ohmori, M ^a   Sakamoto, K ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Drug interaction; Lomefloxacin; Ranitidine; Renal clearance

Indexed keywords

LOMEFLOXACIN; PLACEBO; RANITIDINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG URINE LEVEL; HUMAN; HUMAN EXPERIMENT; KIDNEY CLEARANCE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; URINARY EXCRETION;

ADULT; ANTI-INFECTIVE AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; FLUOROQUINOLONES; HISTAMINE H2 ANTAGONISTS; HUMANS; MALE; QUINOLONES; RANITIDINE;

EID: 0029740813     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050167     Document Type: Article

References (16)

1. Wolfson JS, Hooper DC (1989) Fluoroquinolone antimicrobial agents. Clin Microbiol Rev 2:378-424
2. Nakashimu M, Uematsu T, Takiguchi Y, Mizuno A, Kanamaru M, Kubo S, Takahara Y, Okezaki E, Nagata O (1988) Phase I study on NY-198. Chemotherapy (Tokyo) 36 [Suppl 2]:201-239
3. Hoffler D, Waetcke K, Koeppe P, Metz R, Sorgel F (1989) Pharmacokinetics of lomefloxacin in normal and impaired renal function. Acta Ther 15:321-336
4. Gower PE, Dash CH (1969) Cephalexin: Human studies of absorption and excretion of a new cephalosporin antibiotic. Br J Pharmacol 37:738-747
5. Van Crugten J, Bochner F, Keal J, Somogyi A (1986) Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs. J Pharmacol Exp Ther 236:481-487
6. Kaji M, Saito A, Shimada J, Ohmori M, Shiba K, Yamaji T, Hojo T, Okuda S, Hori S, Saegusa M, Miyahara T, Ueda Y (1988) Clinical studies on NY-198. Chemotherapy (Tokyo) 36 [Suppl 2]:513-526
7. Sudoh T, Fujimura A, Shiga T, Sasaki M, Harada K, Tateishi T, Ohashi K, Ebiharn A (1994) Renal clearance of lomefloxacin is decreased by furosemide. Eur J Clin Pharmacol 46:267-269
8. Kosoglou T, Vlasses PH (1989) Drug interaction involving renal transport mechanisms: an overview. DICP 23:116-122
9. Soniogyi A, Bochner F (1984) Dose and concentration dependent effect of ranitidine on procainamide disposition and renal clearance in man. Br J Clin Pharmacol 18:175-181
10. Muirhead M, Bochner F, Somogyi A (1988) Pharmacokinetic drug interactions between triamterene and ranitidine in humans: alterations in renal and hepatic clearance and gastrointestinal absorption. J Pharmacol Exp Ther 244:734-739
11. Okezaki E, Makino E, Ohmichi K, Nagata O, Yamada T, Takahashi K, Terasaki T, Tsuji A (1988) Disposition and metabolism of NY-198 II. HPLC and bioassay studies of absorption and excretion in the dog. Chemotherapy (Tokyo) 36[Suppl 2]: 138-143
12. Somoeyi A (1987) New insights into the renal secretion of drugs. TIPS 8:354-357
13. Morrison PJ, Mant TGK, Norman GT, Robinson J, Kunka RL (1988) Pharmacokinetics and tolerance of lomefloxacin after sequentially increasing oral doses. Antimicrob Agents Chemother 32:1503-1507
14. Gros I, Carbon C (1990) Pharmacokinetics of lomefloxacin in healthy volunteers: Comparison of 400 milligrams once daily and 200 milligrams twice daily given orally for 5 days. Antimicrob Agents Chemother 34:150-152
15. Blum RA, Schultz RW, Schentag JJ (1990) Pharmacokinetics of lomefloxacin in renally compromised patients. Antimicrob Agents Chemother 34:2364-2368
16. Freeman CD, Nicolan DP, Belliveau PP, Nightingale CH (1993) Lomefloxacin clinical pharmacokinetics. Clin Pharmacokinet 25:6-19