11β-hydroxysteroid dehydrogenase activity in the hippocampus: Implications for in vivo corticosterone receptor binding and cell nuclear retention

Journal of Neuroendocrinology

Volumn 8, Issue 8, 1996, Pages 595-600

  Van Haarst, Aernout D ^a   Welberg, Leonie A M ^a   Sutanto, Win ^a   Oitzl, Melly S ^a   Ron de Kloet, E ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

11 hydroxysteroid dehydrogenase; Corticosterone; Hippocampus; Mineralocorticoid receptor

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; ALDOSTERONE; CARBENOXOLONE; CORTICOSTEROID RECEPTOR; CORTICOSTERONE; DEOXYCORTICOSTERONE; GLUCOCORTICOID RECEPTOR; GLYCYRRHETINIC ACID; MINERALOCORTICOID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0029740799     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.1996.tb00693.x     Document Type: Article

References (32)

1. Edwards CRW, Stewart PM, Burt D et al. Localisation of 11β-hydroxysteroid dehydrogenase - tissue specific protector of the mineralocorticoid receptor. Lancet 1988; 2: 986-989.
2. Funder JW, Pearce PT, Smith R, Smith AI. Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science 1988; 242: 583-585.
3. Lakshmi V, Sakai RR, McEwen BS, Monder C. Regional distribution of 11 beta-hydroxysteroid dehydrogenase in rat brain. Endocrinology 1991; 128: 1741-1748.
4. Moisan M-P, Seckl JR, Brett LP et al. 11 beta-hydroxysteroid dehydrogenase messenger ribonucleic acid expression, bioactivity and immunoreactivity in rat cerebellum. J Neuroendocrinol 1990; 2: 853-858.
5. Moisan M-P, Seckl JR, Edwards CRW. 11β-Hydroxysteroid dehydrogenase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus and cortex. Endocrinology 1990; 127(3): 1450-1455.
6. Sakai RR, Lakshmi V, Monder C, McEwen BS. Immunocytochemical localization of 11 beta-hydroxysteroid dehydrogenase in hippocampus and other brain regions of the rat. J Neuroendocrinol 1991; 4: 101-106.
7. De Kloet ER, Wallach G, McEwen BS. Differences in corticosterone and dexamethasone binding to rat brain and pituitary. Endocrinology 1975; 96: 598-609.
8. McEwen BS, Zigmond RE. Isolation of brain cell nuclei. Res Meth Neurochem 1972; 1: 140-161.
9. Edwards CRW, Hayman A. Enzyme protection of the mineralo-corticoid receptor: evidence in favour of the hemi-acetal structure of aldosterone. In: Bonvalet JP, Farman N, Lombès M, Rafestin-Oblin ME, eds. Aldosterone: Fundamental Aspects, Vol. 215, John Libbey Eurotext Ltd, 1991; 215: 67-75.
10. Van Haarst AD, Szuran ThF. Steroid hormone binding to intracellular receptors: in vitro and in vivo studies. In: De Kloet ER, Sutanto W, eds. Neurobiology of Steroids, San Diego: Academic Press, 1994: 79-95.
11. Van Steensel B, Van Haarst AD, De Kloet ER, Van Driel R. Binding of corticosteroid receptors to rat hippocampus nuclear matrix. FEBS Lett 1991; 292: 229-231.
12. Gomez-Sanchez EP, Gomez-Sanchez CE. Central hypertensinogenic effects of glycyrrhizic acid and carbenoxolone. Am J Physiol 1992; 263: E1125-E1130.
13. Seckl JR, Kelly PA, Sharkey J. Glycyrrhetinic acid, an inhibitor of 11 beta-hydroxysteroid dehydrogenase, alters local cerebral glucose utilization in vivo. J Steroid Biochem Mol Biol 1991; 39: 777-779.
14. Albiston AL, Obeyesekere VR, Smith RE, Krozowski ZS. Cloning and distribution of the human 11β-hydroxysteroid dehydrogenase type 2 enzyme. Mol Cell Endocrinol 1994; 105: R11-R17.
15. Brown RW, Chapman KE, Edwards CRW, Seckl JR. Human Placental 11-beta-hydroxysteroid dehydrogenase - evidence for and partial purification of a distinct NAD-dependent isoform. Endocrinology 1993; 132: 2614-2621.
16. Rusvai E, Naray Fejes Toth A. A new isoform of 11 beta-hydroxysteroid dehydrogenase in aldosterone target cells. J Biol Chem 1993; 268: 10717-10720.
17. Agarwal AK, Mune T, Monder C, White PC. NAD +-dependent isoform of 11β-hydroxysteroid dehydrogenase; cloning and characterization of cDNA from sheep kidney. J Biol Chem 1994; 269: 25959-25962.
18. Lakshmi V, Nath N, Muneyyirci Delale O. Characterization of 11 beta-hydroxysteroid dehydrogenase of human placenta: evidence for the existence of two species of 11 beta-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol 1993; 45: 391-397.
19. Yang K, Yu M. Evidence for distinct isoforms of 11β-hydroxysteroid dehydrogenase in the ovine liver and kidney. J Steroid Biochem Mol Biol 1994; 49: 245-250.
20. Stewart PM, Murry BA, Mason JI. Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type i isoform. J Clin Endocrinol Metab 1994; 79: 480-484.
21. Roland BL, Li KXZ, Funder JW. Hybridization histochemical localization of 11 β-hydroxysteroid dehydrogenase type 2 in rat brain. Endocrinology 1995; 136: 4697-4700.
22. Roland BL, Krozowski ZS, Funder JW. Glucocorticoid receptor, mineralocorticoid receptors, 11 beta-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: in situ studies. Mol Cell Endocrinol 1995; 111: R1-R7.
23. Levin N, Akana SF, Jacobson L et al. Plasma adrenocorticotropin is more sensitive than trancortin production or thymus weight to inhibition by corticosterone in rats. Endocrinology 1987; 121: 1104-1110.
24. Agarwal AK, Tusie Luna MT, Monder C, White PC. Expression of 11 beta-hydroxysteroid dehydrogenase using recombinant vaccinia virus. Mol Endocrinol 1990; 4: 1827-1832.
25. Lakshmi V, Monder C. Purification and characterization of the corticosteroid 11 β-dehydrogenase component of the rat liver 11 β-hydroxysteroid dehydrogenase complex. Endocrinology 1988; 123: 2390-2398.
26. Rajan V, Edwards CRW, Seckl JR. 11β-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. J Neurosci 1996; 16: 65-70.
27. Brakkee JH, Wiegant VM, Gispen WH. A simple technique for rapid implantation of a permanent cannula into the rat brain ventricular system. Lab Anim Sci 1979; 29: 78-81.
28. Reul JMHM, De Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985; 117: 2505-2512.
29. Sutanto W, De Kloet ER. Species-specificity of corticosteroid receptors in hamster and rat brains. Endocrinology 1987; 121: 1404-1411.
30. Sutanto W, De Kloet ER. ZK91587 and structurally-related antimin-eralocorticoids: highly selective mineralocorticoid (Type I) receptor ligands in the rat brain. Drugs of the Future 1989; 14: 1093-1100.
31. Torelli V, Hardy M, Nedelec L, Tournemine C, Deraedt R, Philibert D. 7α-Alkyl steroidal spirolactones as potent aldosterone antagonists, Abstract 19. J Steroid Biochem 1982; 17.
32. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Polin phenol reagent. J Biol Chem 1951; 193: 265-275.