The effectiveness of two ciprofloxacin formulations for experimental Pseudomonas and Staphylococcus keratitis

Japanese Journal of Ophthalmology

Volumn 40, Issue 2, 1996, Pages 212-219

  Engel, Lee S ^a   Callegan, Michelle C ^a   Hill, James M ^a,b   Folkens, Alan T ^c   Shimomura, Yoshikazu ^b,d   O'Callaghan, Richard J ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LSU EYE CENTER   (United States)

^c ALCON RESEARCH LTD   (United States)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Ciloxan ; Ciprofloxacin PSS; Keratitis; Pseudomonas; Rabbits; Staphylococcus

Indexed keywords

BENZALKONIUM CHLORIDE; CIPROFLOXACIN; EDETIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CONJUNCTIVA DISEASE; CONTROLLED STUDY; CORNEA; DRUG FORMULATION; KERATITIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RABBIT; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-INFECTIVE AGENTS; BENZALKONIUM COMPOUNDS; CHELATING AGENTS; CIPROFLOXACIN; COLONY COUNT, MICROBIAL; CORNEA; DISEASE MODELS, ANIMAL; EDETIC ACID; EYE INFECTIONS, BACTERIAL; KERATITIS; OPHTHALMIC SOLUTIONS; PRESERVATIVES, PHARMACEUTICAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RABBITS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 0029740501     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Adams J, Wilcox MJ, Trousdale MD et al: (1992) Morphologic and physiologic effects of artificial tear formulations on corneal epithelial derived cells. Cornea 11: 234-241
2. Berdy GJ, Abelson MB, Smith LM & George MA: (1992) Preservative-free artificial tear preparations: Assessment of corneal toxic effects. Arch Ophthalmol 110: 528-532
3. Burstein NL: (1980) Corneal cytotoxicity of topically applied drugs, vehicles and preservatives. Surv Ophthalmol 25: 15-30
4. Burstein NL: (1984) Preservative alteration of corneal permeability in humans and rabbits. Invest Ophthalmol Vis Sci 25: 1453-1457
5. Callegan MC, Engel LS, Hill JM & O'Callaghan RJ: (1994) Ciprofloxacin versus tobramycin for the treatment of Staphylococcus keratitis. Invest Ophthalmol Vis Sci 35: 1033-1037
6. Callegan MC, Hobden JA, Hill JM et al: (1992) Topical antibiotic therapy for the treatment of experimental Staphylococcus aureus keratitis. Invest Ophthalmol Vis Sci 33: 3017-3023
7. Callegan MC, O'Callaghan RJ & Hill JM: (1994) Pharmokinetic considerations in the treatment of bacterial keratitis. Clin Pharmacokinet 27: 129-149
8. Collin HB & Carrol N: (1986) Ultrastructure changes to the corneal endothelium due to benzalkonium chloride. Acta Ophthalmol 64: 226-231
9. Donowitz LG: (1991) Benzalkonium chloride is still in use. Infect Control Hosp Epidemiol 12: 186-187
10. Engel LS, Callegan MC, Hill JM & O'Callaghan RJ: (1993) Bioassay for quantitating ciprofloxacin and tobramycin in aqueous humor. J Ocular Pharmacol 9: 311-320
11. Gasset AR, Ishi Y, Kaufman HE & Miller T: (1974) Cytotoxicity of ophthalmic preservatives. Am J Ophthalmol 78: 98-105
12. Hobden JA, Rootman DS, O'Callaghan RJ & Hill JM: (1988) Iontophoretic application of tobramycin to uninfected and Pseudomonas aeniginosa-infected rabbit corneas. Antimicrob Agents Chemother 32: 978-981
13. Hobden JA, Reidy JJ, O'Callaghan RJ & Hill JM: (1990) Ciprofloxacin iontophoresis for aminoglycoside-resistant pseudomonal keratitis. Invest Ophthalmol Vis Sci 31: 1940-1944
14. Hobden JA, Reidy JJ, O'Callaghan RJ et al: (1990) Quinolones in collagen shields to treat aminoglycoside-resistant pseudomonal keratitis. Invest Ophthalmol Vis Sci 31: 2241-2243
15. Ichijima H, Petroll WM, Jester JV & Cavanagh HD: (1992) Confocal microscopic studies of living rabbit cornea treated with benzalkonium chloride. Cornea 11: 221-225
16. Jani R, Gan O, Ali Y et al: (1994) Ion exchange resins for ophthalmic delivery. J Ocular Pharmacol 10: 57-67
17. Johnson MK, Hobden JA, Hagenah M et al: (1990) The role of pneumolysin in ocular infections with Streptococcus pneumoniae. Curr Eye Res 9: 1107-1114
18. Jones DB: (1981) Decision making in the management of microbial keratitis. Ophthalmology 88: 814-820
19. Lauffenburger MD & Cohen KL: (1993) Topical ciprofloxacin versus topical fortified antibiotics in rabbit models of Staphylococcus and Pseudomonas keratitis. Cornea 126: 517-521
20. Leibowitz HM: (1991) Clinical evaluation of ciprofloxacin 0.3% ophthalmic solution for treatment of bacterial keratitis. Am J Ophthalmol 112: 34s
21. Lemp MA & Zimmerman LD: (1988) Toxic endothelial degeneration in ocular surface disease treated with topical medications containing benzalkonium chloride. Am J Ophthalmol 105: 670-673
22. McDermott ML, Tran TD, Cowden JW & Bugge CJL: (1993) Corneal stromal penetration of topical ciprofloxacin in humans. Ophthalmology 100: 197-200
23. Meyer I: (1993) Sodium polystyrene sulfonate: A cation exchange resin used in treating hyperkalemia. ANNA J 20: 93-95
24. Olson RJ: (1993) Preservatives in ophthalmic topical medications: A significant cause of disease. J Ocular Pharmacol 9: 363-364
25. Parks DJ, Abrams DA, Sarfarazi FA & Katz HR: (1993) Comparison of topical ciprofloxacin to conventional antibiotic therapy in the treatment of ulcerative keratitis. Am J Ophthalmol 115: 471-477
26. Pfister RR & Burstein N: (1976) The effects of ophthalmic drugs, vehicles, and preservatives on corneal epithelium: A scanning electron microscope study. Invest Ophthalmol 15: 246-259
27. Podder SK, Moy KC & Lee VH: (1992) Improving the safety of topically applied timolol in the pigmented rabbit through manipulation of formulation composition. Exp Eye Res 54: 747-757
28. Reidy JJ, Hobden JA, Hill JM et al: (1991) The efficacy of topical ciprofloxacin and norfloxacin in the treatment of experimental Pseudomonas keratitis. Cornea 10: 25-28
29. Reller LB, Schoenknecht FD, Kenny MA & Sherris JC: (1974) Antibiotic susceptibility testing of Pseudomonas aeruginosa: Selection of a control strain and criteria for magnesium and calcium content in the media. J Infect Dis 130: 454-463
30. Rootman DS, Hobden JA, Jantzen JA et al: (1988) Iontophoresis of tobramycin for the treatment of experimental Pseudomonas keratitis in the rabbit. Arch Ophthalmol 106: 262-265
31. SAS Institute, Inc: (1987) SAS/STAT Guide for Personal Computers, Version 6 Edition. SAS Institute, Cary
32. Smith BR: (1990) National cooperative study of ciprofloxacin susceptibility in the United States. Curr Ther Res 47: 962-970
33. Waring GO & Rodrigues MM: (1987) Patterns of pathologic response in the cornea. Surv Ophthalmol 31: 262-266