Studies on the molecular mechanisms of meningococcal interactions with human cells: Towards anti-adhesion measures for the control of meningococcal disease

Advances in Experimental Medicine and Biology

Volumn 408, Issue , 1996, Pages 113-122

  Virji, Mumtaz ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; CELL SURFACE RECEPTOR; OUTER MEMBRANE PROTEIN;

BACTERIAL OUTER MEMBRANE; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM PILUS; CONFERENCE PAPER; CYTOTOXICITY; EPIDEMIC MENINGITIS; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NEISSERIA MENINGITIDIS; PRIORITY JOURNAL; PROTEIN DETERMINATION;

BACTERIA (MICROORGANISMS); NEISSERIA MENINGITIDIS;

EID: 0029738986     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4613-0415-9_13     Document Type: Conference Paper

References (40)

1. Cannon, J.G. (1994) In Neisscria 94. Genetics and function of Opa proteins: Progress and unanswered questions. Proceedings of the Ninth International Pathogenic Neisseria Conference, pp. 70-72. Editors J.S. Evans, S.E. Yost, M.C.J. Maiden and I.M. Feavers.
2. Cartwright, K.A.V. Stuart, J.M., Jones, D.M. and Noah, N.D. (1987) The Stonehouse survey: nasopharyngeal carriage of meningococcal and Neisseria lactamica. Epidem Inf 99: 591-601.
3. Castric, P. (1995) PilO, a gene required for glycosylation of Pseudomonas aeruginosa 1244 pilin. Microbiology 141: 1247-1254.
4. DeVoe, I.W. (1982) The Meningococcus and Mechanisms of Pathogenicity. Microb Reviews 46: 162-190.
5. DeVoe, I.W., and Gilchrist, J.E. (1975) Pili on meningococci from primary cultures of nasopharyngeal carriers and cerebrospinal fluid of patients with acute disease. J Exp Med 141: 297-305.
6. Diaz, J.-L., Virji, M. & Heckels, J.E. (1984). Structural and antigenic differences between two types of meningococcal pili. FEMS Microb Lett 21, 181-184.
7. Dunn, K.L.R., Virji, M. and Moxon, E.R. (1995) Investigations into the molecular basis of meningococcal toxicity for human endothelial and epithelial cells: the synergistic effect of LPS and pili. Microb Pathogen 18: 81-96.
8. Garbe, T., Harris, D., Vordermeier, M., Lathigra, R., Ivanyi, J. and Young, D. (1993) Expression of the Mycobacterium tuberculosis 19-kilodalton antigen in Mycobacterium smegmatis - immunological analysis and evidence of glycosylation. Infect Immun 61: 260-267.
9. Jonsson, A.-B., Nyberg, G. and Normark, S. (1991) Phase variation of gonococcal pili by frameshift mutation in pilC, a novel gene for pilus assembly. EMBO J 10: 477-488.
10. Jonsson, A. -B., Iver, D., Falk. P., Pepose, J. and Normark, S. (1994) Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue. Mol Microbiol 13: 403-416.
11. McNeil, G., Virji, M. and Moxon, E.R. (1994a) Interactions of Neisseria meningitidis with human monocytes. Microb Pathogen 16, 153-163.
12. McNeil, G., Virji, M. and Moxon, E.R. (1994b). Interactions of Neisseria meningitidis expressing Ope and Opa proteins with human phagocytes. In Neisseria 94. Proceedings of the Ninth International Pathogenic Neisseria Conference. pp. 265-267. Editors J.S. Evans, S.E. Yost, M.C.J. Maiden and I.M. Feavers.
13. McNeil, G. and Virji, M. (1996). Phenotypic variants of meningococci and their potential in phagocytic interactions: the influence of opacity proteins, pili, PiIC and surface sialic acids (submitted to Microb Pathogen).
14. Nassif, X., Lowry, J. Stenberg, P., O'Gaora, P., Ganji, A. and So, M. (1993) Antigenic variation of pilin regulates adhesion of Neisseria meningitidis to human epithelial cells. Mol Microbiol 8: 719-725.
15. Nassif, X., Beretti, J-L., Lowy, J., Stenberg, P., O'Gaora, P., Pfeifer, J., Normark, S., and So, M. (1994) Roles of pilin and PiIC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells. Proc Nat Acad Sci USA 91: 3769-3773.
16. Olyhoek, A.J.M., Sarkari, J., Bopp, M., Morelli, G. and Achtman, M. (1991) Cloning and expression in Escherichia coli of opc, the gene for an unusual Class 5 outer membrane protein from Neisseria meningitidis. Microb Pathogen 11: 249-257.
17. Perry, A.C.F., Nicolson, I.J. and Saunders, J.R. (1988) Neisseria meningitidis C114 contains silent, truncated pilin genes that are homologous to Neisseria gonorrhoeae pil sequences J Bacteriol 170: 1691-1697.
18. Rudel, T., van Putten, J.P.M., Gibbs, C.P., Haas, R. and Meyer, T.F. (1992) Interaction of two variable proteins (pilE and pilC) required for pilus-mediated adherence of Neisseria gonorrhoeae to human epithelial cells. Mol Microbiol 6: 3439-3450.
19. Ruoslahti, E., and Pierschbacher, M.D. (1987) New Perspectives in Cell Adhesion: RGD and Integrins. Science 238:491-497.
20. Saunders, J.R., O'Sullivan, H., Wakeman, J., Sims, G., Hart, C.A., Virji, M., Heckels, J.E., Winstanley, C., Morgan, J.A.W. & Pickup, R.W. (1994) Flagella and pili as antigenically variable structures on the bacterial surface. In Microbial Cell Envelopes: Interactions and Biofilms, pp. 33-42, Edited by L.B. Ouesnel, P. Gilbert and P.S. Handley, Blackwell Scientific Publications.
21. Sharon, N. and Jeanloz, R.W. (1960) The diaminohexose component of a polysaccharide isolated from Bacillus subtilis. J Biol Chem 235: 1-5.
22. Stephens, D.S. (1989) Gonococcal and meningococcal pathogenesis as defined by human cell, cell culture and organ culture assays. Clin Microbiol Rev 2: S104-S111.
23. Stimson, E., Virji, M., Makepeace, K., Dell, A., Morris, H.R., Payne, G., Saunders, J.R., Jennings, M.P., Barker, S., Panico, M., Blench, I. and Moxon, E.R. (1995) Meningococcal pilin: a glycoprotein substituted with digalactosyl 2,4-diacetamido-2,4,6-trideoxyhexose. Mol Microbiol 17(6): 1201-1214.
24. Stimson, E., Virji, M., Barker, S., Panico, M., Blench, I. Saunders, J.R., Payne, G., Moxon, E.R., Dell, A. and Morris, H.R. (1996) Discovery of a novel protein modification: α-glycerophosphate is a substituent of meningococcal pilin. (Biochem J. in press)
25. Trust, T.J., Gillespie, R.M., Bhatti, A.R. and White, L.A. (1983) Differences in the adhesive properties of Neissseria meningitidis for human buccal epithilial cells and erythrocytes. Infect Immun 41: 106-113.
26. Virji, M., Heckels, J.E., Potts, W.J., Hart, C.A. and Saunders, J.R. (1989). Identification of the epitopes recognised by monoclonal antibodies SM1 and SM2 which react with all pili of Neisseria gonorrhoeae but which differentiate between two structural classes of pili expressed by Neisseria meningitidis and the distribution of their encoding sequences in the genomes of Neisseria spp. J Gen Microbiol 135: 3239-3251.
27. Virji, M., Kayhty, H., Ferguson, D.J.P., Alexandrescu, C., Heckels, J.E. and Moxon, E.R. (1991a) The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cells. Mol Microbiol 5: 1831-1841.
28. Virji, M., Kayhty, H., Ferguson, D.J.P., Alexandrescu, C., and Moxon, E.R. (1991b) Interactions of Haemophilus influenzae with cultured human endothelial cells. Microb Pathogen 10: 231-245.
29. Virji, M., Alexandrescu, C., Ferguson, D.J.P., Saunders, J.R. and Moxon, E.R. (1992a) Variations in the expression of pili: the effect on adherence of Neisseria meningitidis to human epithelial and endothelial cells. Mol Microbiol 6: 1271-1279.
30. Virji, M., Makepeace, K., Ferguson, D.J.P., Achtman, M., Sarkari, J. and Moxon, E.R. (1992b) Expression of the Ope protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidis. Mol Microbiol 6: 2785-2795.
31. Virji, M., Saunders, J.R., Sims, G., Makepeace, K., Maskell, D. and Ferguson. J.P. (1993a) Pilus-facilitated adherence of Neisseria meningitidis to human epithelial and endothelial cells: modulation of adherence phenotype occurs concurrently with changes in amino acid sequence and the glycosylation status of pilin. Mol Microbiol 10: 1013-28.
32. Virji, M., Makepeace, K., Ferguson, D.J.P., Achtman, M. & Moxon, E.R. (1993b). Meningococcal Opa and Ope proteins: their role in colonisation and invasion of human epithelial and endothelial cells. Mol Microbiol 10(3), 499-510.
33. Virji, M., Makepeace, K. & Moxon, E.R. (1994a). Distinct mechanisms of interaction of Ope-expressing meningococci at apical and basolateral surfaces of human endothelial cells; the role of integrins in apical interactions. Mol Microbiol 14(1), 173-184.
34. Virji, M., Makepeace, K., & Moxon, E.R. (1994b). In Neisseria 94. Meningococcal outer-membrane Ope mediates interactions with multiple extracellular matrix components. Proceedings of the Ninth International Pathogenic Neisseria Conference. pp. 263-264. Editors J.S. Evans, S.E. Yost, M.C.J. Maiden and I.M. Feavers.
35. Virji, M. Makepeace, K., Peak, I., Payne, G., Saunders, J.R., Ferguson, D.J.P. and Moxon, F.R. (1995a) Functional implications of the expression of PiIC proteins in meningococci. Mol Microbiol 16(6): 1087-1097.
36. Virji, M., Makepeace, K., Peak, I.R.A., Ferguson, D.J.P., Jennings, M.P. and Moxon, E.R. (1995b) Ope- and pilus- dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides. Mol Microbiol, 18 (4): 741-754.
37. Virji, M., Stimson, E., Makepeace, K., Dell, A., Morris, H.R., Payne, G., Saunders, J.R. and Moxon, E.R. (1996) Post-translational modifications of meningococcal pili: identification of a common trisaccharide substitution on variant pilins of strain C31I. In Microbial Pathogenesis and Immune Response II. Annals of The New York Academy of Sciences. (in press).
38. Wang, J.F., Caugant, D.A., Morelli, G., Koumare, B. and Achtman, M. (1993) Antigenic and epidemiologic properties of the ET-37 complex of Neisseria meningitidis. J Infect 167(6):1320-1329
39. Whittakcr, D.V., Parolis, L.A.S. and Parolis, H. (1994) Escherichia coli K48 capsular polysaccharide: a glycan containing a novel diacetamido sugar. Carbohydr Res 256: 289-301.
40. Zehavi, U. and Sharon, N. (1973) Structural studies of 4-acetamido-2-amino-2,4,6-trideoxy-D-glucose (N-Acetylbacillosamine), the N-acetyl-diamino sugar of Bacillus licheniformis. J. Biol. Chem. 248: 433-438.