Anti-CD69 antibodies enhance phorbol-dependent glucose metabolism and Ca2+ levels in human thymocytes. Antagonist effect of cyclosporin A

Journal of Leukocyte Biology

Volumn 60, Issue 2, 1996, Pages 278-284

  Conde, M ^a   Montano R ^a   Moreno Aurioles, V R ^a   Ramirez, R ^a   Sanchez Mateos, P ^c   Sanchez Madrid, F ^c   Sobrino, F ^a,b  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Calcium; Diacylglycerol; Glycolysis; Immunosuppression

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; CALCIUM; CD69 ANTIGEN; CYCLOSPORIN A; DIACYLGLYCEROL; MONOCLONAL ANTIBODY; PHORBOL ESTER; PYRUVATE KINASE;

ARTICLE; CELL MATURATION; CONTROLLED STUDY; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; THYMOCYTE;

EID: 0029738985     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.60.2.278     Document Type: Article

References (49)

1. Meuer, S. C., Hodgdon, J. C., Hussey, R. E., Potentis, J. P., Schlossman, S. F., Reinherz, E. L. (1983) Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J. Exp. Med. 158, 988-993.
2. Cebrian, M., Yagüe, E., Rincon, M., Lopez-Botet, M., O. de Landazuri, M., Sanchez-Madrid, F. (1988) Triggering of T cell proliferation through AIM, an activation inducer molecule expressed on activated human lymphocytes. J. Exp. Med. 168, 1621-1637.
3. Hara, T., Jung, L. K. L., Bjorndahl, J. M., Fu, S. M. (1986) Rapid induction of a phosphorylated 28kD/32kD disulfide-linked early activation antigen (EA1) by 12-o-tetradecanoyl phorbol-13-acetate, mitogens and antigens. J. Exp. Med. 164, 1988-2005.
4. Lanier, L. L., Buck, D. W., Rhodes, L., Ding, A., Evans, E., Barney, C., Phillips, J. H. (1988) Interleukin-2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. J. Exp. Med. 167, 1572-1585.
5. Cosulich, M. E., Rubartelli, A., Risso, A., Cozzolino, F., Bargellesi, A. (1987) Functional characterization of an antigen involved in an early step of T cell activation. Proc. Natl. Acad. Sci. USA 84, 4205-4209.
6. Sanchez-Mateos, P., Cebrian, M., Acevedo, A., Lopez-Botet, M., de Landazuri, M. O., Sanchez-Madrid, F. (1989) Expression of a gp33/27000 MW activation inducer molecule (AIM) on human lymphoid tissues. Induction of cell proliferation on thymocytes and B lymphocytes by anti-AIM antibodies. Immunology 68, 72-79.
7. 2+ and activation of protein kinase C. J. Immunol. 142, 1854-1860.
8. Sanchez-Mateos, P., Sanchez-Madrid, F. (1991) Structure-function relationship and immunochemical mapping of external and intracellular antigen sites on the lymphocyte activation inducer molecule, AIM/CD69. Eur. J. Immunol. 21, 2317-2325.
9. Lopez-Cabrera, M., Santis, A. G., Fernandez-Ruiz, E., Blacher, R., Esch, F., Sanchez-Mateos, P., Sanchez-Madrid, F. (1993) Molecular cloning, expression, and chromosomal localization of the human earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type animal lectin superfamily of signal transmitting receptors. J. Exp. Med. 178, 537-547.
10. Hamann, J., Fiebig, H., Strauss, M. J. (1993) Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a c-type lectin domain. J. Immunol. 150, 4920-4927.
11. Ziegler, S. F., Ramsdell, F., Hjerrild, K. A., Armitage, R. J., Grabstein, K. H., Hennen, K. B., Farrah, T., Fanslow, W. C., Shevach, E. M., Alderson, M. R. (1993) Molecular characterization of the early activation antigen CD69: a type II membrane glycoprotein related to a family of natural killer cell activation antigens. Eur. J. Immunol. 23, 1643-1648.
12. Lucas, B., Vaseur, F., Penit, C. (1994) Production, selection, and maturation of thymocytes with high surface density of TCR. J. Immunol. 153, 53-62.
13. + thymocytes. Eur. J. Immunol. 23, 739-746.
14. Testi, R., D'Ambrosio, D., De Maria, R., Santoni, A. (1994) The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol. Today 15, 479-483.
15. Izon, D. J., Jones, L. A., Eynon, E. E., Kruisbeek, A. M. (1994) A molecule expressed on accessory cells, activated T cells, and thymic epithelium is a marker and promoter of T cell activation. J. Immunol. 153, 2939-2950.
16. Shevach, E. M., Oppenheim, J. J. (1981) T-lymphocytes development and function. In Cellular Function in Immunity and Inflamation (J. J. Oppenheim, D. L. Rosenstreich, and M. Potter, eds.), London, Edward Arnold, 161-186.
17. Bendelac, A., Matzinger, P., Seder, R. A., Paul, W. E., Schwartz, R. H. (1992) Activation events during thymic selection. J. Exp. Med. 175, 731-742.
18. Boyd, R. L., Tucek, C. L., Godfrey, D. I., Izon, D. J., Wilson, T. J., Davidson, N. J., Bean, A. G. D., Ladyman, H. M., Ritter, M. A., Hugo, P. (1993) The thymic microenviroment. Immunol. Today 14, 445-459.
19. Morella, A., Poggi, A., Pende, D., Tripodi, G., Orengo, A. M., Pella, N., Augugliaro, R., Bottino, C., Ciccone, E. Morella, L. (1991) CD69-mediated pathway of lymphocyte activation: Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor α/β. J. Exp. Med. 174, 1393-1398.
20. Testi, R., Pulcinelli, F., Frati, L., Gazzaniga, P. P., Santoni, A. (1990) T cell activation via Leu-23 (CD69): CD69 is expressed on platelets and mediates platelet activation and aggregation. J. Exp. Med. 172, 701-707.
21. Testi, R. Phillips, J. H., Lanier, L. L. (1989) T cell activation via Leu-23 (CD69). J. Immunol. 143, 1123-1128.
22. Santis, A. G., Campanero, M. R., Alonso, J. L., Tugores, A., Alonso, M. A., Yagúe, E., Pivel, J. P., Sanchez-Madrid, F. (1992) Tumor necrosis factor-α production induced in T lympocytes through the AIM/CD69 activation pathway. Eur. J. Immunol. 22, 1253-1259.
23. Martin, F., Gualberto, A., Sobrino, F., Pintado, E. (1991) Thimerosal induces calcium mobilization, fructose 2,6-biphosphate synthesis and cytoplasmic alkalinization in rat thymus lymphocytes. Biochim. Biophys. Acta 1091, 110-114.
24. Chiara, M. D., Sobrino, F. (1991) Modulation of the inhibition of respiratory burst in mouse macrophages by cyclosporin A: effect of in vivo treatment, glucocorticoids and the state of activation of cells. Immunology 72, 133-137.
25. Maizel, A. L, Mehta, S. R., Ford, R. J., Lachman, L. B. (1981) Effect of interleukin-1 on human thymocytes and purified human T cells. J. Exp. Med. 153, 470-475.
26. Moreno-Aurioles, V. R., Sobrino, F. (1991) Glucocorticoids inhibit fructose 2,6-biphosphate synthesis in rat thymocytes. Opposite effect of cycloheximide. Biochim. Biophys. Acta 1091, 96-100.
27. Markwell, M. A. K., Huas, S. M., Bieber, L. L., Tulbert, N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples. Anal. Biochem. 87, 206-210.
28. Bustos, R., Sobrino, F. (1992) Stimulation of glycolysis as an activation signal in rat peritoneal macrophages. Biochem. J. 282, 299-303.
29. Bartrons, R., Hue, L., Van Schaftingen, E., Hers, H-C. (1983) Hormonal control of fructose 2,6-bisphosphate concentration in isolated rat hepatocytes. Biochem. J. 214, 829-837.
30. Bontemps, F., Hue, L., Hers, H. G. (1978) Phosphorylation of glucose in isolated rat hepatocytes. Biochem. J. 174, 603-611.
31. Hue, L. (1981) The role of futile cycles in the regulation of carbohydrate metabolism in the liver. Adv. Enzymol. 52, 247-331.
32. Sobrino, F., Ruiz, G., Goberna, R. (1982) Stimulating role of potassium ions and ouabain on glycogen synthesis in adipose tissue. Biochem. J. 208, 261-268.
33. Bligh, E. G., Dyer, W. J. (1957) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
34. Billah, M. M., Eckel, S., Mullmann, T. J., Egan, R. W., Siegel, M. I. (1989) Phosphatidylcholine hydrolysis by phospholipase D determines phosphatidate and diglyceride levels in chemotactic peptide-stimulated human neutrophils. J. Biol. Chem. 264, 17069-17077.
35. Hue, L., Rider, M. H. (1987) Role of fructose 2,6-bisphosphate in the control of glycolysis in mammalian tissues. Biochem. J. 245, 313-324.
36. Borel, J. F., Feurer, C., Gubler, H. U., Stähelin, H. (1976) Biological effects of cyclosporin A. Agents Actions 6, 468-475.
37. Wiesinger, D., Borel, J. F. (1979) Studies on the mechanism of action of cyclosporin A. Immunobiol. [Stuttgart] 156, 452-463.
38. Wilkinson, P. C., Higging, A. (1987) Cyclosporin A inhibits mitogen-activated but not phorbol ester-activated locomotion of human lymphocytes. Immunology 61, 311-316.
39. Bell, R. M., Coleman, R. A. (1980) Enzymes of glycerolipid synthesis in eukariotes. Annu. Rev. Biochem. 49, 459-487.
40. Yokoyama, W. M., Koning, F., Kehn, P. J., Pereira, G. M. B., Stingl, G., Coligan, J. E., Shevach, G. M. (1988) Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation. J. Immunol. 141, 369-376.
41. 2+ and membrane potential in lymphocytes. Nature 295, 68-71.
42. Pilkis, S. J., Claus, T. H., Kurland, I. J., Lange, A. J. (1995) 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme. Annu. Rev. Biochem. 64, 799-835.
43. Boscà, L., Mojena, M., Diaz-Guerra, M. J. M., Marquez, C. (1988) Phorbol 12,13-dibutyrate and mitogens increase fructose 2,6-bisphosphate in lymphocytes. Comparison of lymphocyte and rat-liver 6-phosphofructo-2-kinase, Eur. J. Biochem. 175, 317-323.
44. Exton, J. H. (1980) Mechanism involved in α-adrenergic phenomena: role of calcium ions in action of catecholamines in liver and other tissues. Am. J. Physiol. 238, E3-E12.
45. Clipstone, N. A., Crabtree, G. R. (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
46. 2+ levels. J. Exp. Med. 163, 654-664.
47. Rist, R. J., Jones, G. E., Naftalin, R. J. (1990) Synergistic activation of 2-deoxy-D-glucose uptake in rat and murine peritoneal macrophages by human macrophage colony-stimulating factor-stimulates coupling between transport and hexokinase activity and phorbol-dependent stimulation of pentose phosphate-shunt activity. Biochem. J. 265, 243-249.
48. Tejwani, G. A., Chauhan, S., Duruibe, V., Vaswani, K. K. (1985) Enhancement in the activities of mouse epidermal glucose-6-phosphate dehydrogenase, hexokinase, phosphofructokinase and pyruvate kinase by 12-o-tetradecanoyl-phorbol-13-acetate. Arch. Biochem. Biophys. 239, 462-466.
49. Risso, A., Smilovich, D., Capra, M. C., Baldisarro, I., Yan, C., Bargellesi, A., Cosulich, M. E. (1991) CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. J. Immunol. 146, 4105-4114.