Age-related diminution of dopamine antagonist-stimulated vesamicol receptor binding

Journal of Nuclear Medicine

Volumn 37, Issue 7, 1996, Pages 1192-1197

  Efange, Simon M N ^a,b   Langason, Rosemary B ^a   Khare, Anil B ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIV OF MINNESOTA HOSP AND CLINIC   (United States)

Author keywords

aging; cholinergic function; iodine 125 MIBT vesamicol receptor

Indexed keywords

3 IODOBENZYLTROZAMICOL I 125; ACETYLCHOLINE; DOPAMINE RECEPTOR BLOCKING AGENT; ETICLOPRIDE; HALOPERIDOL; SPIPERONE; UNCLASSIFIED DRUG; VESAMICOL;

AGING; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BRAIN TISSUE; CHOLINERGIC SYSTEM; CONTROLLED STUDY; DRUG RECEPTOR BINDING; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; LIGAND BINDING; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SENESCENCE; TISSUE DISTRIBUTION;

AGING; ANIMALS; BRAIN; DOPAMINE ANTAGONISTS; HALOPERIDOL; IODINE RADIOISOTOPES; IODOBENZENES; MALE; PIPERIDINES; RATS; RATS, INBRED F344; RATS, WISTAR; RECEPTORS, CHOLINERGIC; SALICYLAMIDES; TIME FACTORS;

EID: 0029738654     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Drachman DA. Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology 1977;27:783-790.
2. Molchan SE, Mellow AM, Lawlor BA, et al. TRH attenuates scopolamine-induced memory impairment in humans. Psychopharmacology 1990;100:84-89.
3. Bartus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory function. Science 1982;217:408-417.
4. Perry RH, Blessed G, Perry EK, Tomlinson BE. Histochemical observations on the cholinesterase activities in the brains of elderly normal and demented (Alzheimer-type) patients. Age Aging 1980;9:9-16.
5. Perry EK. The cholinergic system in old age and Alzheimer's disease. Age Aging 1980;9:1-8.
6. McGeer PL, McGeer EG, Suzuki J, Dolman CE, Nagai T. Aging, Alzheimer's disease and the cholinergic system of the basal forebrain. Neurology 1984;34:741-745.
7. Rylett RJ, Ball MJ, Calhoun EH. Evidence for high-affinity choline transport in synaptosomes prepared from hippocampus and neocortex of patients with Alzheimer's disease. Brain Res 1984;289:169-175.
8. Gottfries CG. Neurochemical aspects on aging and diseases with cognitive impairment. J Neuroscience Res 1990;27:541-547.
9. Muller WE, Stoll L, Schubert T, Gelmann CM. Central cholinergic functioning and aging. Acta Psychiatr Scand Suppl 1991;366:34-39.
10. Sherman KA, Friedman E. Pre- and postsynaptic cholinergic dysfunction in aged rodent brain regions: new findings and an interpretative review. Intl J Dev Neurosci 1990;8:689-708.
11. Consolo S, Wang J-X, Fiorentini F, Vezzani A, Ladinsky H. In vivo and in vitro studies on the regulation of cholinergic neurotransmission in striatum, hippocampus and cortex of aged rats. Brain Res 1986;374:212-218.
12. 3H]acetylcholine release. Mech Aging Dev 1993;72: 119-128.
13. Wu CF, Bertorelli R, Sacconi M, Pepeu G, Consolo S. Decrease of brain acetylcholine release in aging freely-moving rats detected by microdialysis. Neurobiol Aging 1988;9:357-361.
14. 125I]MIBT): potential radioligand for mapping central cholinergic innervation. J Med Chem 1993;36:1754-1760.
15. Parsons SM, Prior C, Marshall IG. Acetylcholine transport, storage and release. Intl Rev Neurobiol 1993;35:279-390.
16. Rogers GA, Kornreich WD, Hand K, Parsons SM. Kinetic and equilibrium characterization of vesamicol receptor-ligand complexes with picomolar dissociation constants. Mol Pharmacol 1993;44:633-641.
17. 3H]Dopa in various regions of the brain. J Neurochem 1966;13:655-669.
18. Day J, Fibiger HC. Dopaminergic regulation of cortical acetylcholine release. Synapse 1992;12:281-286.
19. Casamenti F, Bianchi C, Beani L, Pepeu G. Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs. Eur J Pharmacol 1980;65:279-284.
20. Consolo S, Girotti P, Zambelli M, Russi G, Benzi M, Bertorelli R. D1 and D2 dopamine receptors and the regulation of striatal acetylcholine release in vivo. Progr Brain Res 1993;98:201-207.
21. Bertorelli R, Zambelli M, Di Chiara G, Consolo S. Dopamine depletion preferentially impairs D1 over D2 receptor regulation of striatal in vivo acetylcholine release. J Neurochem 1992;59:353-357.
22. 18F]FBT): molecular decomposition-reconstitution approach to vesamicol receptor radioligands for positron emission tomography. Appl Radiat Isot 1994;45:465-472.
23. Efange SMN, Mach RH, Smith CR, Khare AB, Foulon C, Akella SK, Childers SR, Parsons SM. Vesamicol analogs as sigma ligands: molecular determinants of selectivity at the vesamicol receptor. Biochem Pharmacol 1995;49:791-797.
24. Ingvar M, Stone-Elander S, Rogers GA, Johansson B, Eriksson L, Parsons SM, Widen L. Striatal D2/acetylcholine interactions: PET studies of the vesamicol receptor. Neuroreport 1993;4:1311-1314.
25. Stoof JC, Drukarch B, de Boer P, Westerink BHC, Groenewegen HJ. Regulation of the activity of striatal cholinergic neurons by dopamine. Neuroscience 1992;47:755-770.
26. Consolo SP, Girotti P, Zambelli M, Russi G, Benzi M, Bertorelli R. D1 and D2 dopamine receptors and the regulation of striatal acetylcholine release in vivo. Progr Neurobiol 1993;98:201-207.
27. 18F]fluoroethyl)benperidol to primate cerebral dopaminergic D2 receptors demonstrated, in vivo by PET. Neurosci Lett 1992;148:97-100.
28. Jope RS, Johnson GVW. Quinacrine and 2-(4-phenylpiperidino)cyclohexanol (AH5183) inhibit acetylcholine release and synthesis in rat brain slices. Molec Pharmacol 1986;29:45-51.
29. Searl T, Prior C, Marshall IG. Acetycholine recycling and release at motor nerve terminals studied using (-)-vesamicol and troxylpyrrolium. J Physiol 1991;444:99-116.
30. Thompson JM, Makino CL, Whitaker JR, Joseph JA. Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices. Brain Res 1984;299:169-173.
31. Marshall IG. Studies on the blocking action of 2-(4-phenylpiperidino)cyclohexanol (AH5183). Br J Pharmacol 1970;38:503-516.
32. Ricny J, Collier B. Effect of 2-(4-phenylpiperidino)cyclohexanol on acetylcholine release and subcellular distribution in rat slices. J Neurochem 1986;47:1627-1633.
33. Morgan DG, Marcusson JO, Nyberg P, Wester P, Winblad B, Gordon MN, Finch CE. Divergent changes in D1 and D2 dopamine binding sites in human brain during aging. Neurobiol Aging 1987;8:195-201.
34. Morelli M, Mennini T, Cagnotto A, Toffano G, Di Chiara G. Quantitative autoradiographical analysis of the age-related modulation of central dopamine D1 and D2 receptors. Neuroscience 1990;36:403-410.
35. 125I]MIBT) reveals blunting of the striatal cholinergic response to dopamine D2 receptor blockade in the 6-hydroxydopamine (6-OHDA)-lesioned rat: possible implications for Parkinson's disease. Life Sci 1996; 58:1367-1374.
36. Dobie DJ, Merchant KM, Hamblin MW, Vatassery GT, Dysken MW, Dorsa DM. Blunting of the neurotensin mRNA response to haloperidol in the striatum of aging rats: possible relationship to decline in the dopamine D2 receptor expression. Brain Res 1993;616:105-113.