Inhibitory effect of salmeterol on the respiratory burst of adherent human neutrophils

Clinical and Experimental Immunology

Volumn 106, Issue 1, 1996, Pages 97-102

  Ottonello, L ^a   Morone, P ^a   Dapino, P ^a   Dallegri, F ^a,b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Neutrophils; Phosphodiesterase; Repiratory burst; Type IV inhibitors; 2 agonists

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; CYCLIC AMP; FORMYLMETHIONYLLEUCYLPHENYLALANINE; PROPRANOLOL; PROSTAGLANDIN E2; SALBUTAMOL; SALMETEROL; SUPEROXIDE;

ARTICLE; HUMAN; HUMAN CELL; MALE; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL; RESPIRATORY BURST;

EID: 0029738384     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-804.x     Document Type: Article

References (36)

1. Jennings CA, Crystal RG. Inflammatory lung disease: molecular determinants of emphysema, bronchitis and fibrosis. In: Gallin JI, Goldstein IM, Snyderman R, eds. Inflammation: basic principles and clinical correlates. New York: Raven Press. Ltd, 1992:983 93.
2. Becker EL. The formylpeptide receptor of the neutrophil. Am J Pathol 1987; 129:16 24.
3. Carp H. Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils. J Exp Med 1982; 185:264 75.
4. Weiss SJ. Tissue destruction by neutrophils. N Fngl J Med 1989; 320:365 76.
5. Katsumata U, Miura M, Ichinose M et al. Oxygen radicals produce airway constriction and hyperresponsiveness in anesthetized cats. Am Rev Respir Dis 1990; 141:1158 61.
6. Postma DS, Renkema TE, Noordhock JA et al. Association between nonspecific bronchial hyperreactivily and Superoxide anion production by polymorphonuclear leukocytes in chronic air-flow obstruction. Am Rev Resp Dis 1988; 137:57 61
7. Nielson CP, Vestal RE, Sturm RJ et al Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. J Allergy Clin Immunol 1990; 86:801 8.
8. Torphy TJ, Undem BJ. Phosphodiesterase inhibitors: new opportunities for the treatment of asthma. Thorax 1991; 46:512 23.
9. Davies P, MacIntyre DE. Prostaglandins and inflammation. In: Gallin JI, Goldstein IM, Snyderman R. eds. Inflammation: basic principles and clinical correlates. New York: Raven Press, Ltd. 1992:123 38.
10. Wright CD, Kuipers PJ, Kobylarz-Singer D et al. Differential inhibition of human neutrophil functions. Role of cyclic AMP-specific, cyclic GMP-insensitive phosphodiesterase. Biochem Pharmacol 1990; 40:699 707.
11. Bevifacqua M, Vago T, Baldi G et al. Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV. Eur J Pharmacol 1994; 268:415 23.
12. Nielson CP. β-adrenergic modulation of the polymorphonuclear leukocyte respiratory burst is dependent upon the mechanism of cell activation. J Immunol 1987; 139:2392 7.
13. Opdhal H, Benestad HB, Nicolaysen G. Effect of β-adrenergic agents on human neutrophil granulocyte activation with formylmethionyl-leucyl-phenylalanine and phorbol myristate acetate. Pharmacol Toxicol 1993; 72:221 8.
14. 2) production and bacterial killing of human alveolar macrophages. Am Rev Respir Dis 1991; 143:A329.
15. 2-agonist with prolonged duration of action. Lung 1993; 171:249 64.
16. 2-adrenoceptor agonists: a new perspective in the treatment of asthma. Eur Respir J 1991; 4:219 61.
17. Rabe KF, Giembycz MA, Dent G et al. Salmeterol is a competitive antagonist at β-adrenoceptors mediating inhibition of the respiratory burst in guinea-pig eosinophils. Eur J Pharmacol 1993; 231:305 8.
18. Ottonello L, Morone P, Dapino P et al. Cyclic AMP-elevating agents down-regulate the oxidative burst induced by granulocyte-macrophage colony-stimulating factor (GM-CSF) in adherent neutrophils. Clin Exp Immunol 1995; 101:502 6.
19. Dankberg F, Persidsky M. A test of granulocyte membrane integrity and phagocyte function. Cryobiology 1976; 13:430 5.
20. Dapino P, Dallegri F, Ottonello I. et al. Induction of neutrophil respiratory burst by tumor necrosis factor-alpha; priming effect of solid-phase fibronectin and intervention of CD11b-CD18 integrins. Clin Exp Immunol 1993; 94:533 8.
21. Leslie RGQ. Evaluation and improvement of a rapid microassay for measuring superoxide anion production by phagocytes. 1. Spectrophotometric aspect. J Immunol Methods 1987; 103:253 9.
22. Santini GF, Battistin S, De Paoli P et al. A method for determination of adherence of granulocytes to microtitre plates. J Immunol Methods 1987; 100:153 6.
23. Fridovich I. Xanthine oxidase, In: Greenwald RA, ed. Handbook of methods for oxygen radical research. Boca Raton: CRC Press Inc. 1986:51 53.
24. 2) integrins act synergistically to lower cAMP in human neutrophils. J Cell Biol 1990; 111:2171 81.
25. Sozzani S, Agwu DE, MeCall CE et al. Propranolol, a phosphatidate phosphohydrolase inhibitor, also inhibits protein kinase C. J Biol Chem 1992; 267:20481 8.
26. Fantozzi R, Brunelleschi S, Cremonesi P et al. Drug modulation of superoxide anion production from human neutrophils. Int J Tiss Reac 1985; 7:149 52.
27. Fantozzi R. Autocoid and β-adrenergic agonist modulation of N-formylmethionyl-leucyl-phenylalanine evoked lysosomal enzyme release from human neutrophils. Agents Actions 1984; 14:441 50.
28. Baker AJ, Fuller RW. Anti-inflammatory effect of salmeterol on human alveolar macrophages. Am Rev Resp Dis 1990; 141:A394.
29. Johnson M, Butchers PR, Coleman RA et al. The pharmacology of salmeterol. Life Sci 1993; 52:2131 43.
30. 2 adrenoreceptor pathway, Eur Respir J 1993; 6:308S.
31. Sekut L, Champion BR, Page K et al. Anti-intlammatory activity of salmeterol: down regulation of cytokine production. Clin Exp Immunol 1995; 99:461 6.
32. Nathan CF. Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes. J Clin Invest 1987; 80:1550 60.
33. Abramson SB, Weissmann G. The mechanisms of action of non-steroidal antiinflammatory drugs. Arthritis Rheum 1989;32:1 9.
34. Calhoun WJ, Stevens CCA, Lambert SB. Modulation of superoxide production of alveolar macrophages and peripheral blood mononuclear cells by β-agonists and theophylline. J Lab Clin Med 1991; 117:514 22.
35. Butchers PR, Vardey CJ, Johnson M. Salmeterol: a potent and long-acting inhibitor of inflammatory mediator release from human lung. Br J Pharmacol 1991; 104:672 6.
36. Nicholson CD, Challiss RAJ, Shahid M. Differential modulation of tissue function and therapeuthic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TIPS 1991; 12:19 27.