N(G)-Nitro-L-arginine-methyl-ester protects against ischaemia-induced biochemical changes and hippocampal neurodegeneration in the gerbil

Human Psychopharmacology

Volumn 11, Issue 4, 1996, Pages 299-307

  Caldwell, Maeve ^b   O'Neill, Michael ^c   Earley, Bernadette ^d   Leonard, B E ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c ELI LILLY AND COMPANY   (United States)

^d Grange Research Center   (Ireland)

Author keywords

Hippocampus CA1; Histology; Homecage activity; Ischaemia; Mongolian gerbil; N(G) nitro L arginine methyl ester; Nitric oxide synthase

Indexed keywords

N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; GERBIL; HIPPOCAMPUS; HYPERACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL;

EID: 0029738138     PISSN: 08856222     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1077(199607)11:4<299::AID-HUP772>3.0.CO;2-E     Document Type: Article

References (38)

1. Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A. and Freeman, B. A. (1990). Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and Superoxide. Proceedings of the National Academy of Sciences, USA, 87, 1620-1624.
2. Beckman, J. S. and Tsai, J. H. (1994). Reactions and diffusion of nitric oxide and peroxynitrite. The Biochemist, Oct/Nov, 8-10.
3. Bradford, M. M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
4. Bredt, D. S. and Snyder, S. H. (1990). Isolation of nitric oxide synthase, a calmodulin requiring enzyme. Proceedings of the National Academy of Sciences, USA, 87, 682-685.
5. Bredt, D. S. and Snyder, S. H. (1992). Nitric oxide: a novel neuronal messenger. Neuron 8, 3-11.
6. Buisson, A., Plotkine, M. and Boulu, R. G. (1992). The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. British Journal of Pharmacology, 106, 766-767.
7. G-nitro-L-arginine protects against ischaemia-induced increases in nitric oxide and hippocampal neurodegeneration in the gerbil. European Journal of Pharmacology, 260, 191-200.
8. Chi, O. Z., Anwar, M., Sinha, A. K. and Weiss, H. R. (1991). Effects of MK-801 on cerebral regional oxygen consumption in focal cerebral ischaemia in rats. Brain Research, 69, 414-419.
9. Choi, D. W. (1990). The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annual Review of Neuroscience, 13, 171-182.
10. Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S. and Snyder, S. H. (1991). Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proceedings of the National Academy of Sciences, USA, 88, 6368-6371.
11. Demopoulos, H. B., Flamm, E. S., Pietronigro, D. D. and Seligman, M. L. (1980). The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiologica Scandinavica, 492, 91-119.
12. Elben, U., Kitter, B. and Rudolphi, K. (1992). Stroke therapy research: current trends. Drugs of Today, 28, 333-351.
13. Garthwaite, J., Garthwaite, G., Palmer, R. M. J. and Moncada, S. (1989). NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. European Journal of Pharmacology, 172, 413-416.
14. Garthwaite, J. (1991). Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends in Neuroscience, 14, 60-67.
15. Ginsberg, M. D. and Busto, R. (1989). Rodent models of ischaemia. Stroke, 20, 1627-1642.
16. Hall, E. D. and Braughler, J. M. (1989). Central nervous system trauma and stroke. 11. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation. Free Radicals in Biology and Medicine, 6, 303-313.
17. Hibbs, J. B., Taintor, R. R. and Vavrin, Z. (1987). Macrophage cytotoxicity: role of L-arginine deaminase and imino nitrogen oxidation to nitrite. Science, 235, 473-476.
18. Hibbs, J. B., Jr., Taintor, R. R., Vavrin, Z. and Rachlin, E. M. (1988). Nitric oxide: a cytotoxic activated effector molecule. Biochemical and Biophysical Research Communications, 157, 87-94.
19. Katoh, A., Ishibashi, C., Shiomi, T., Takahara, Y. and Eigyo, T. (1992). Ischaemia-induced irreversible deficit of memory function in gerbils. Brain Research, 577, 57-63.
20. Koppenol, W. H., Moreno, J. J., Pryor, W. A., Ischiropoulos, H. and Beckman, J. S. (1992). Peroxynitrate, a cloaked oxidant formed by nitric oxide and superoxide. Chemical Research in Toxicology, 5, 834-842.
21. Kruskal, W. H. and Wallis, W. A. (1952). Use of ranks in one-criterion variance analysis. Journal of the American Statistical Association, 47, 583-621.
22. Levine, S. and Payan, H. (1969). Effects of ischemia and other procedures on the brain and retina of the gerbil (Meriones unguiculatus). Experimental Neurology, 16, 255-262.
23. Mann, H. B. and Whitney, D. R. (1947). On a test of whether one or two random variables is stochastically larger than the other. Annals of Mathematics and Statistics, 18, 50-60.
24. Marletta, M. A. (1989). Nitric oxide: biosynthesis and biological significance. Trends in Neuroscience, 14, 488-492.
25. Mileson, B. E. and Schwartz, R. D. (1991). The use of locomotor activity as a behavioural screen for neuronal damage following transient forebrain ischemia in gerbils. Neuroscience Letters, 128, 71-76.
26. Moncada, S., Palmer, R. M. J. and Higgs, E. A. (1991). Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacological Reviews, 4, 109-141.
27. G-nitro-L-arginine mitigates ischaemic brain edema and subsequent cerebral infarction in rats. Neuroscience Letters, 147, 159-162.
28. Nishizaki, T. and Okada, Y. (1988). Effects of excitatory amino acids on the oxygen consumption of hippocampal slices from the guinea pig. Brain Research, 452, 11-19.
29. Nowicki, J. P., Duval, D., Poignet, H. and Scaton, B. (1991). Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. European Journal of Pharmacology, 204, 339-340.
30. Raichle, M. E. (1983). The pathophysiology of brain ischaemia. Annals of Neurology, 13, 2-9.
31. Siesjo, B. K., Agardh, C. D. and Bengtsson, F. (1989). Free radicals and brain damage. Cerebellum and Brain Metabolism Reviews, 1, 165-211.
32. G-monomethyl-L-arginine derivatives following focal cerebral ischaemia in the rat. In Pharmacology of Cerebral Ischaemia, Kriegelstein, J. and Oberpichler, H., (Eds), Wissenschaftliche Verlagsgesellschaft, Stuttgart, pp. 427-431.
33. Stuehr, D. J. and Nathan, C. F. (1989). Nitric oxide. A macrophage product responsible for cytostatis and respiratory inhibition in tumour target cells. Journal of Experimental Medicine, 169, 1543-1555.
34. G-nitro-L-arginine in focal stroke in the 7-day-old rat. European Journal of Pharmacology, 218, 197-198.
35. G-nitro-L-arginine of L-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy. Neuroscience, 55, 893-901.
36. G-nitro-L-arginine enhances neuronal death following ischemia in gerbils. Neuroscience Letters, 146, 139-142.
37. Xue, D., Huang, Z. G., Gertler, S. Z. and Buchan, A. M. (1992). Blockade of nitric oxide synthetase by nitroarginine failed to protect the brain against transient focal ischaemia in two rat MCA models. Society of Neuroscience, 18 Part 2, 1254-1260.
38. Yamamoto, S., Galanow, E. V, Berger, S. B. and Reis, D. J. (1992). Inhibition of NO synthesis increases focal ischaemic infarction in the rat. Journal of Cerebral Blood Flow and Metabolism, 12, 717-726.