Oxygen radical formation due to the effect of varying hydrogen ion concentrations on cytochrome P450-catalyzed cyclosporine metabolism in rat and human liver microsomes

Advances in Experimental Medicine and Biology

Volumn 387, Issue , 1996, Pages 135-139

  Ahmed, S Sohail ^a   Napoli, Kimberly L ^a   Strobel, Henry W ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOCHROME; BENZPHETAMINE; CARBON TETRACHLORIDE; CYCLOSPORIN A; CYTOCHROME C; CYTOCHROME P450; MALONALDEHYDE; MIXED FUNCTION OXIDASE; OXIDOREDUCTASE; OXYGEN RADICAL; PROTON;

ANIMAL CELL; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG METABOLISM; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER MICROSOME; NONHUMAN; PH; PRIORITY JOURNAL; RAT;

EID: 0029738019     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4757-9480-9_19     Document Type: Conference Paper

References (7)

1. Ahmed, S. S., Strobel, H. W., Napoli, K., and Grevel, J.: Adrenochrome reaction implicates oxygen radicals in metabolism of cyclosporine A and FK-506 in rat and human liver microsomes. J. Pharm. and Exp. Therap. 265(3): 1047-1054..
2. Dignam, J. D. and Strobel, H. W.: NADPH-cytochrome P-450 reductase from rat liver: Purification by affinity chromatography and characterization. Biochemistry. 16: 1116-1123, 1977.
3. Grogan, J., Shou, M., Zhou, D., Chen, S., and Korzekwa, K. R.: Use of aromatase (CYP 19) metabolite ratios to characterize electron transfer from NADPH-cytochrome P450 reductase. Biochem. 32: 12007-12012, 1993.
4. Hille, R., Fee, J. A., and Massey, V.: Equilibrium properties of xanthine oxidase containing FAD analogs of varying oxidation-reduction potential. J. Biol. Chem. 256(17): 8933-8940, 1981.
5. Nelson, D. R. and Strobel, H. W.: On the membrane topology of vertebrate cytochrome P450 proteins. J. Biol. Chem. 263:6038-6050, 1988.
6. Shen, S. and Strobel, H. W.: Role of lysine and arginine residues of cytochrome P450 in the interaction between cytochrome P450 2B1 and NADPH-cytochrome P450 reductase. Arch. Bioch. and Biophysics. 304(1): 257-265, 1993.
7. Whiting, P. H., Simpson, J. G., Davidson, R. J. L. and Thomson, A. W.: Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosages for 7 weeks. Br. J. Exp. Pathol. 64: 437-444, 1983.