Health and respirable particulate (PM10) air pollution: A causal or statistical association?

Environmental Health Perspectives

Volumn 104, Issue 8, 1996, Pages 838-850

  Gamble, John F ^a   Lewis, R Jeffrey ^a  

^a EXXONMOBIL UPSTREAM RESEARCH COMPANY   (United States)

Author keywords

Air pollution; Air quality standards; Causality; Confounding; Ecologic time series studies; Epidemiology; Morbidity; Mortality; Particulate matter; Weather

Indexed keywords

AIR POLLUTION; AIR QUALITY STANDARD; ARTICLE; DISEASE ASSOCIATION; EPIDEMIOLOGY; HEALTH; HEART DISEASE; HUMAN; LUNG DISEASE; MORBIDITY; MORTALITY; PARTICULATE MATTER; PRIORITY JOURNAL; UNITED STATES; WEATHER;

EID: 0029737438     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.96104838     Document Type: Article

References (97)

1. Hill AB. The environment and disease: association or causation? Proc R Soc Med 58:295-300 (1965).
2. Pope CA III, Bates DV, Raizenne ME. Health effects of particulate air pollution: time for reassessment? Environ Health Perspect 103: 472-480 (1995).
3. Styer P, McMillan N, Gao F, Davis J, Sacks J. Effect of outdoor airborne particulate matter on daily death counts. Environ Health Perspect 103:490-497 (1995).
4. 10 air pollution? Additional analyses by location, year, season, and cause of death. Inhalation Toxicol 7:603-614 (1995).
5. 10 pollution in Utah Valley. Arch Environ Health 42:211-217 (1992).
6. Schwartz J. Air pollution and daily mortality in Birmingham, Alabama. Am J Epidemiol 137: 1136-1147 (1993).
7. Li Y, Roth HD. The analysis of the association between particulate matter and daily mortality in Birmingham, Toronto, and Philadelphia in particulate matter: health and regulatory issues. Proceedings of an International Specialty Conference, Air and Waste Water Management Association, Pittsburgh, PA, 4-6 April 1995. Pittsburgh, PA:Air and Waste Water Management Association, 1995;43-59.
8. Schwartz J, Dockery DW. Increased mortality in Philadelphia associated with daily air pollution concentrations. Am Rev Respir Dis 45:600-604 (1992).
9. Schwartz J. What are people dying of on high air pollution days? Environ Res 64:26-35 (1994).
10. Li Y, Roth HD. Daily mortality analysis by using different regression models in Philadelphia County, 1973-1990. Inhalation Toxicol 1:45-58 (1995).
11. Saldiva PHN, Lichtenfels AJFC, Paiva PSO, Barone IA, Martins MA, Massad E, Pereira JCR, Xavier VP. Association between air pollution and mortality due to respiratory diseases in children in São Paulo, Brazil: a preliminary report. Environ Res 65:218-225 (1994).
12. Saldiva PHN, Pope CA, Dockery DW, Lichtenfels AJ, Salge JM, Barone I, Bohm GM. Air pollution and mortality in elderly people: a time-series study in São Paulo, Brazil. Arch Environ Health 50:159-163 (1995).
13. Schwartz J. Air pollution and daily mortality: a review and meta-analysis. Environ Res 64:36-52 (1994).
14. Ostro B. The association of air pollution and mortality: examining the case for inference. Arch Environ Health 48:336-342 (1993).
15. Samet JM, Bishop Y, Speizer FE, Spengler JD, Ferris BG Jr. The relationship between air pollution and emergency room visits in an industrial community. J Air Pollut Control Assoc 31: 236-240 (1981).
16. Bates DV, Sizto R. Air pollution and hospital admissions in southern Ontario: the summer haze effects. Environ Res 43:317-331 (1987).
17. Bates DV, Baker-Anderson M, Sizto R. Asthma attack periodicity: a study of hospital emergency visits in Vancouver. Environ Res 51:51-70 (1990).
18. Schwartz J, Spix C, Wichmann HE, Malin E. Air pollution and acute respiratory illness in five German communities. Environ Res 56:1-14 (1991).
19. Schwartz J, Slater D, Larson TV, Pierson WE, Koenig JQ. Particulate air pollution and hospital emergency room visits for asthma in Seattle. Am Rev Respir Dis 147:826-831 (1993).
20. Sunyer J, Saez M, Murillo C, Castellsague J, Martinez F, Anto JM. Air pollution and emergency room admissions for chronic obstructive pulmonary disease: a 5-year study. Am J Epidemiol 137:701-775 (1993).
21. Schwartz J. Air pollution and hospital admissions for the elderly in Birmingham, Alabama. Am J Epidemiol 139:589-598 (1994).
22. Schwartz J. Air pollution and hospital admissions for the elderly in Detroit, Michigan. Am J Respir Crit Care Med 150:648-655 (1994).
23. Schwartz J. Short-term fluctuations in air pollution and hospital admissions of the elderly for respiratory disease. Thorax 50:531-538 (1995).
24. Lebowitz MD, Collins L, Holberg CJ. Time-series analyses of respiratory responses to indoor and outdoor environmental phenomena. Environ Res 43:332-341 (1987).
25. 10 pollution: a daily time-series analysis. Am Rev Respir Dis 144:668-674 (1991).
26. 10 pollution on symptomatic and asymptomatic children. Am Rev Respir Dis 145:1123-1128 (1992).
27. Ostro BD, Lipsett MJ, Mann JK, Krupnick A, Harrington W. Air pollution and respiratory morbidity among adults in southern California. Am J Epidemiol 137:691-700 (1993).
28. Hoek G, Brunekreef B. Acute effects of a winter air pollution episode on pulmonary function and respiratory symptoms of children. Arch Environ Health 48:328-335 (1993).
29. Utell MJ, Frampton MW. Particles and mortality: a clinical perspective. Inhalation Toxicol 7:645-655 (1995).
30. Canny GJ, Reisman J, Healy R, Schwartz C, Petrou AS, Rebuck AS, Levison H. Acute asthma: observations regarding the management of a pediatric emergency room. Pediatrics 83:507-512 (1989).
31. Bates DV. Health indices of the adverse effects of air pollution: the question of coherence. Environ Res 59:336-349 (1992).
32. Samet JM, Zeger SL, Berhane K. Particulate air pollution and daily mortality: replication and validation of selected studies. The Phase I Report of the Particle Epidemiology Evaluation Project, Health Effects Institute. Cambridge, MA:Health Effects Institute, 1995.
33. Schwartz J, Dockery DW. Particulate air pollution and daily mortality in Steubenville. Am J Epidemiol 135:12-19 (1992).
34. Moolgavkar SH, Luebeck EG, Hall TA, Anderson EL. Particulate air pollution, sulfur dioxide, and daily mortality: a reanalysis of the Steubenville data. Inhalation Toxicol 1:35-44 (1995).
35. Moolgavkar SH, Luebeck EG, Hall TA, Anderson EL. Air pollution and daily mortality in Philadelphia. Epidemiology 6:476-484.
36. Wyzga RE, Lipfert FW. Temperature-pollution interactions with daily mortality in Philadelphia, in particulate matter: health and regulatory issues. The Proceedings of an International Specialty Conference, Air and Waste Water Management, Pittsburgh, PA, 4-6 April 1995. Pittsburgh, PA:Air and Waste Water Management Association, 1995;3-42.
37. Samet JM. Particulate air pollution and mortality: the Philadelphia story. Epidemiology 6:471-473 (1995).
38. Ito K, Thurston GD, Hayes C, Lippmann M. Associations of London, England, daily mortality with particulate matter, sulfur dioxide, and acidic aerosol pollution. Arch Environ Health 48:213-220 (1993).
39. Lippmann M, Ito K. Separating the effects of temperature and season on daily mortality from those of air pollution in London: 1965-1972. Inhalation Toxicol 7:85-98 (1995).
40. Derriennic F, Richardson S, Mollie A, Lellouch J. Short-term effects of sulphur dioxide pollution or mortality in two French cities. Int J Epidemiol 18:186-197 (1989).
41. Xu X, Dockery DW, Gao J, Chen Y. Air pollution and daily mortality in residential areas of Beijing, China. Arch Environ Health 49:216-222 (1994).
42. Richardson S, Stücker I, Hémon D. Comparison of relative risks obtained in ecological and individual studies: some methodological considerations. Int J Epidemiol 16:111-120 (1987).
43. Brenner H, Savitz DA, Jöckel K, Greenland S. Effects of nondifferential exposure misclassification in ecologic studies. Am J Epidemiol 135:85-95 (1992).
44. Schwartz S. The fallacy of the ecological fallacy: the potential misuse of a concept and the consequences. Am J Public Health 84:819-824 (1994).
45. Piantadosi S, Byar DP, Green SB. The ecological fallacy. Am J Epidemiol 127:893-904 (1988).
46. Greenland S, Morgenstern H. Ecological bias, confounding, and effect modification. Int J Epidemiol 18:269-274 (1989).
47. Rothman KJ, Poole C. A strengthening programme for weak associations. Int J Epidemiol 17 (4 suppl):955-959 (1988).
48. Wynder EL. Epidemiological issues in weak associations. Int J Epidemiol 19:(suppl 1):S5-S7 (1990).
49. Fairley D. The relationship of daily mortality to suspended particulate in Santa Clara County, 1980-1986. Environ Health Perspect 89:159-168 (1990).
50. Lipfert FW, Hammerstrom T. Temporal patterns in air pollution and hospital admissions. Environ Res 59:374-399 (1982).
51. Lim TK, Ang SM, Rossing TH, Ingenito EP, Ingram RH. The effects of deep inhalation on maximal expiratory flow during intensive treatment of spontaneous asthmatic episodes. Am Rev Respir Dis 140:340-343 (1989).
52. Fanta CH, Rossing TH, McFadden ER. Emergency room treatment of asthma. Am J Med 72:416-422 (1982).
53. Hillman DR, Prentice L, Finucane KE. The pattern of breathing in acute severe asthma. Am Rev Respir Dis 133:587-592 (1986).
54. McFadden ER, Kiser R, DeGroot WJ. Acute bronchial asthma. N Engl J Med 288:221-225 (1973).
55. Woolcock AJ, Read J. Improvement in bronchial asthma not reflected in forced expiratory volume. Lancet 2:1323-1325 (1965).
56. Banner AS, Shah RS, Addington WW. Rapid prediction of need for hospitalization in acute asthma. JAMA 235:1337-1338 (1976).
57. Silverman F, Hosein HR, Corey P, Holton S, Tarlo SM. Effects of particulate matter exposure and medication use on asthmatics. Arch Environ Health 47:51-56 (1992).
58. Pope CA. Combustion-source particulate air pollution and human health: causal association or confounding? In: Particulate matter: health and regulatory Issues. Proceedings of an International Specialty Conference, Air and Waste Water Management, Pittsburgh, PA, 4-6 April 1995. Pittsburgh, PA:Air and Waste Water Management Association, 1995;60-77.
59. Yang S-C, Yang S-P. Respiratory function changes from inhalation of polluted air. Arch Environ Health 49:182-187 (1994).
60. 2, and particulate air pollutants: effects on human pulmonary function and respiratory symptoms. Arch Environ Health 40:197-201 (1985).
61. Bauer MA, Utell MJ, Speers DM, Gibb FR, Morrow PE. Effects of near ambient levels of sulfuric acid aerosol in lung function in exercising subjects with asthma and COPD. Am Rev Resp Dis 137(4)(suppl):167 (1988).
62. Avol EL, Linn WS, Whynot JD, Anderson KR, Shamoo DA, Valencia LM, Little DE, Hackney JD. Respiratory dose-response study of normal and asthmatic volunteers exposed to sulfuric acid aerosol in the sub-micrometer size range. Toxicol Ind Health 4:173-184 (1988).
63. Avol EL, Linn WS, Whynot JD, Anderson KR, Hackney JD. Short-term respiratory effects of sulfuric acid in fog: a laboratory study of healthy and asthmatic subjects. J Air Pollut Control Assoc 38:258-263 (1988).
64. Linn WS, Avol EL, Anderson KR, Shamoo DA, Peng R-C, Hackney JD. Effect of droplet size on respiratory responses to inhaled sulfuric acid in normal and asthmatic volunteers. Am Rev Respir Dis 140:161-166 (1989).
65. Stankus RP, Menon PK, Rando RJ, Glindmeyer H, Salvaggio JE, Lehrer SB. Cigarette smoke-sensitive asthma: challenge studies. J Allergy Clin Immunol 82:331-338 (1988).
66. Menon P, Rando RJ, Stankus RP, Salvaggio JE, Lehrer SB. Passive cigarette smoke - challenge studies: increase in bronchial hyperreactivity. J Allergy Clin Immunol 89:560-566 (1992).
67. Schlesinger RB. Toxicological evidence for health effects from inhaled particulate pollution: does it support the human experience? Inhalation Toxicol 7:99-109 (1995).
68. Oberdörster G, Gelein RM, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: involvement of ultrafine particles. Inhalation Toxicol 7:111-124 (1995).
69. Seaton A, MacNee W, Donaldson K, Godden D. Particulate air pollution and acute health effects. Lancet 345:176-178 (1995).
70. Oberdörster G. Airborne pollutants and acute health effects [letter]. Lancet 345:799-800 (1995).
71. Khaw K-T. Temperature and cardiovascular mortality. Lancet 345:337-338 (1995).
72. Dockery DW, Schwartz J. Particulate air pollution and mortality: more than the Philadelphia story. Epidemiology 6:629-632 (1995).
73. Schwartz J. Particulate air pollution and daily mortality in Detroit. Environ Res 56:204-213 (1991).
74. Dockery DW, Schwartz J, Spengler JD. Air pollution and daily mortality: association with particulates and acid aerosol. Environ Res 59:362-373 (1992).
75. Schwartz J. Total suspended particulate matter and daily mortality in Cincinnati, Ohio. Environ Health Perspect 102:186-189 (1994).
76. 10 associations in Los Angeles. Inhalation Toxicol 7:59-69 (1995).
77. Spengler JD, Treitman RD, Tosteson TD, Mage DT, Soczek ML. Personal exposures to respirable particulates and implications for air pollution epidemiology. Environ Sci Technol 19:700-707 (1985).
78. Dockery DW, Spengler JD. Personal exposure to respirable particulates and sulfates. J Air Pollut Control Assoc 31:153-159 (1981).
79. Cohen BL. Invited commentary: in defense of ecologic studies for testing a linear-no threshold theory. Am J Epidemiol 139:765-768 (1994).
80. Greenland S, Morgenstern H. Problems in ecological studies. Int J Epidemiol 21:424-425 (1992).
81. Stidley CA, Samet JM. A review of ecologic studies of lung cancer and indoor radon. Health Phys 65:234-251 (1993).
82. Lipfert FW, Wyzga RE. Uncertainties in identifying responsible pollutants in observational epidemiology studies. Inhalation Toxicol 7:671-689 (1995).
83. 10 concentrations within two metropolitan areas and their implications to health effect analyses. Inhalation Toxicol 7:735-745 (1995).
84. United States Environmental Protection Agency. National Air Quality and Emissions Trends Report. EPA 454/R-94-026. Research Triangle Park, NC:U.S. Environmental Protection Agency, 1994.
85. Kalkstein LS, Davis RE. Weather and human mortality: an evaluation of demographic and interregional responses in the United States. Ann Assoc Am Geographers 79:44-64 (1989).
86. Thurston GD, Kinney PL. Air pollution epidemiology: considerations in time-series modeling. Inhalation Toxicol 7:71-83 (1995).
87. Sackett DL. Bias in analytic research. J Chron Dis 32:51-63 (1979).
88. Pope CA, Dockery DW, Schwartz J. Review of epidemiological evidence of health effects of particulate air pollution. Inhalation Toxicol 7:1-18 (1995).
89. Kalkstein LS. A new approach to evaluate the impact of climate on human mortality. Environ Health Perspect 96:145-150 (1991).
90. Wilmshurst P. Temperature and cardiovascular mortality. Br Med J 309:1029-1030 (1994).
91. Kunst AE, Looman CWN, Mackenbach JP. Outdoor air temperature and mortality in the Netherlands: a time-series analysis. Am J Epidemiol 137:331-341 (1993).
92. Dunnigan MG, Harland WA, Fyfe T. Seasonal incidence and mortality of ischaemic heart disease. Lancet 2:793-797 (1970).
93. Pan W, Li L, Tsai M. Temperature extremes and mortality from coronary heart disease and cerebral infarction in elderly Chinese. Lancet 345:353-355 (1995).
94. Bull GM. The weather and deaths from pneumonia. Lancet 1:1405-1408 (1980).
95. Rogot E, Padgett SJ. Association of coronary and stroke mortality with temperature and snowfall in selected areas of the United States 1962-1966. Am J Epidemiol 105:565-575 (1976).
96. 10 association in Los Angeles. Inhalation Toxicol 7:59-69 (1995).
97. Mackenbach JP, Looman CWN, Kunst AE. Air pollution, lagged effects of temperature and mortality: the Netherlands 1979-1987. J Epidemiol Community Health 47:121-126 (1993).