The effects of male gender and female sex hormone deficiency on the vascular responses of the rat

Journal of Physiology and Pharmacology

Volumn 47, Issue 3, 1996, Pages 425-432

  Nevala, R ^a   Paakkari, I ^a   Tarkkila, L ^a   Vapaatalo, H ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

gender difference; ovariectomy; vascular reactivity

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM; NORADRENALIN; POTASSIUM CHLORIDE; SEX HORMONE; VASOACTIVE AGENT;

ARTICLE; BLOOD VESSEL REACTIVITY; CARDIOVASCULAR DISEASE; CONCENTRATION RESPONSE; FEMALE; GENDER; HORMONE DEFICIENCY; MALE; MESENTERIC ARTERY; OVARIECTOMY; RAT; RISK; SEX DIFFERENCE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM;

ANIMALS; FEMALE; GONADAL STEROID HORMONES; MALE; MESENTERIC ARTERIES; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITROPRUSSIDE; NOREPINEPHRINE; OVARIECTOMY; POTASSIUM CHLORIDE; RATS; RATS, WISTAR; SEX FACTORS;

EID: 0029736981     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Barret-Connor E, Bush TL. Estrogen and coronary heart disease JAMA, 1881, 265: 1861-1867.
2. Walsh BW, Schiff I, Rosner B, Greenberg L, Ravnikar V, Sacks FM. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N Engl J Med 1991; 24: 325: 1196-204
3. Gruchow HW, Anderson AJ, Barboriak JJ et al. Postmenopausal use of estrogen and occlusion of coronary arteries. Am Heart J 1988; 11: 5, 952-963.
4. Bush TL, Barret-Connor E, Cowan LD. Cardiovascular mortality and noncontraceptive estrogen use in women: results from the Lipid Research, Clinical Program Follow-Up Study Circulation, 1987; 75: 1002-1009
5. Luotola H. Blood pressure and hemodynamics in postmenopausal women during estradiol-17 beta substitution. An Clin Res 1983, 15 Suppl 38: 100-121.
6. Magness RR, Rosenfeld CR. Local and systemic estradiol-17p: effects on uterine and systemic vasodilation. Am J Physiol 1989; 256: Endocrinol Metab 19): E536-542.
7. Freedman RR, Sabharwal SC, Desai N. Sex differences in peripheral vascular adrenergic receptors. Circ Res 1987; 61: 581-585.
8. Kauser K, Rubanyi GM. Gender difference in bioassayable endothelium derived nitric oxide from isolated rat aortae. Am J Physiol 1994; 267: H2311-2317.
9. Futo J, Shay J, Block S, Holt J, Beach M, Moss J. Estrogen and progesterone withdrawal increases cereral vasoreactivity to serotonin in rabit basilar artery. Life Sci 1992; 50: 1165-1172.
10. Cheng DY, Gruetter CA. Chronic estrogen alters contractile responsiveness to angiotensin II and norepinephrine in female rat aorta. Eur J Pharmacol 1992, 215: 171-176.
11. Miller VM, Vanhoutte PM. 17β-Estradiol augments endothelium-dependent contractions to arachidonic acid in rabbit aorta. Am J Physiol 1990; 258: R1502-1507.
12. Morita T. Latifpour J. O'Hollaren B, Wheeler MA, Weiss RM. Sex differences in function and distribution on alpha 1- and alpha 2-adrenoceptors in rabbit urethra. Am J Physiol 1987; 252: F1124-1128.
13. Phillippe M, Saunders T, Bangalore S. A mechanism for testosterone modulation of alpha-1 adrenergic receptor expression in the DDT1 MF-2 smooth muscle myocyte, Mol Cell Biochem 1991; 100: 78-90.
14. Morita T, Tsuchiya N, Tsujii T, Kondo S. Changes of autonomic receptors, following castration and estrogen administration in the male rabbit urethral smooth muscle. Tohoku J Exp Med 1992; 166: 403-405.
15. Xiao XH, Rand MJ. Mechanisms of vasoconstrictor responses to KCl in rat isolated perfused tail arteries: interaction with the alpha 2-adrenoceptor agonist UK14304. Eur J Pharmacol 1991; 196: 133-136.
16. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: Implications for atherosclerosis. Proc Natl Acad Sci 1992; 89: 11259-11263.
17. Hishikawa K, Nakaki T, Marumo T et al. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS 1995; 360: 291-293.
18. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol 1994; 24: 471-476.
19. Lieberman EH, Gerhard MD, Uehata A et al. Estrogen improves endothelium-dependent, flow-mediated vasodilation in postmenopausal women. Ann Int Med 1994; 121: 936-941.
20. Gisclard V, Miller VM, Vanhoutte PM. Effect of 17 beta-estradiol on endothelium-dependent responses in the rabbit. J Pharmacol Exp Ther 1988; 244: 19-22.
21. Williams JK, Adams RM, Klopfenstein HS. Estrogen modulates responses of atherosclerotic coronary arteries. Circulation 1990; 81: 1680-1687.
22. Williams JK, Shively CA, Clarkson TB. Determinationa of coronary artery reactivity in premenopausal female cynomolgus monkeys with diet induced atherosclerosis. Circulation 1994; 90: 983-987.
23. Gilligan DM, Badar DM, Panza JA, Guyyumi AA, Cannon RO. III: Acute vascular effects of estrogen in postmenopausal women. Circulation 1994; 90: 786-791.
24. Jiang C, Sarrel PM, Lindsay DC, Poole-Wilson PA, Collins P. Endothelin-independent relaxation of rabbit coronary artery by 17 β-estradiol in vitro. Br J Pharmacol 1991; 104: 1033-1037.