Correlation between brain MRI lesion volume and disability in patients with multiple sclerosis

Acta Neurologica Scandinavica

Volumn 94, Issue 2, 1996, Pages 93-96

  Mammi, S ^a   Filippi, M ^a,b   Martinelli, V ^a   Campi, A ^a   Colombo, B ^a   Scotti, G ^a   Canal, N ^a   Comi, G ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Brain magnetic resonance imaging; Disability; Lesion volume; Multiple sclerosis

Indexed keywords

ADULT; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DISABILITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE;

EID: 0029736852     PISSN: 00016314     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0404.1996.tb07036.x     Document Type: Article

References (35)

1. KOOPMANS RA, LI DKB, GROCHOWSKI E, et al. Benign versus chronic progressive multiple sclerosis: magnetic resonance imaging features. Ann Neurol 1989: 25: 74-81.
2. BAUMHEFNER RW, TOURTELLOTTE WW, SYNDULKO K, et al. Quantitative multiple sclerosis plaque assessment with magnetic resonance imaging: its correlation with clinical parameters, evoked potentials and intrablood-brain-barrier IgG synthesis. Arch Neurol 1990: 47: 19-26.
3. THOMPSON AJ, KERMODE AG, MACMANUS DG, et al. Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ 1990: 300: 631-634.
4. ISAAC C, LI DKB, GENTON M, et al. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 1988: 38: 1511-1515.
5. MILLER DH, RUDGE P, JOHNSON G, et al. Serial gadolinium-enhanced magnetic resonance imaging in multiple sclerosis. Brain 1988: 111: 927-939.
6. WILLOUGHBY EW, GROCHOWSKI E, LI DKB, et al. Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 1989: 25: 43-49.
7. KERMODE AG, TOFTS PS, THOMPSON AJ, et al. Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology 1990: 40: 229-235.
8. HARRIS JO, FRANK JA, PATRONAS N, et al. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 1991: 29: 548-555.
9. THOMPSON AJ, KERMODE AG, WICKS D, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 1991: 29: 53-62.
10. THOMPSON AJ, MILLER D, YOUL B, et al. Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration. Neurology 1992: 42: 60-63.
11. WIEBE S, LEE DH, KARLIK SJ, et al. Serial cranial and spinal cord magnetic resonance imaging in multiple sclerosis. Ann Neurol 1992: 32: 643-650.
12. CAPRA R, MARCIANÒ N, VIGNOLO LA, et al. Gadolinium-pentetic acid magnetic resonance imaging in patients with relapsing-remitting multiple sclerosis. Arch Neurol 1992: 49: 687-689.
13. FILIPPI M, PATY DW, KAPPOS L, et al. Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: A follow up study. Neurology 1995: 45: 255-260.
14. KHOURY SJ, GUTTMANN CRG, ORAV EJ, et al. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology 1994: 44: 2120-2124.
15. MILLER DH. Magnetic resonance in monitoring the treatment of multiple sclerosis. Ann Neurol 1994: 36: S91-S94.
16. FILIPPI M, BARKER GJ, HORSFIELD MA, et al. A quantitative brain MRI study in benign and secondary progressive multiple sclerosis. J Neurol 1994: 241: 246-251.
17. GASS A, BARKER GJ, KIDD D, et al. Magnetization transfer rate correlates with clinical disability in multiple sclerosis. Ann Neurol 1994: 36: 62-67.
18. VAN WALDERVEEN MAA, BARKHOF F, HOMMES OR, et al. Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short TR/ short TE (T1-weighted) spin-echo images. Neurology 1995: 45: 1684-1690.
19. DE STEFANO N, MATTHEWS PM, ANTEL JP, PREUL M, FRANCIS GS, ARNOLD DL. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995: 38: 901-909.
20. DAVIE CA, BARKER GJ, WEBB S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axonal loss. Brain 1995: 118: 1583-1592.
21. FILIPPI M, CAMPI A, DOUSSET V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995: 45: 478-482.
22. FILIPPI M, CAMPI A, MAMMI S, et al. Brain MRI and multimodal evoked potentials in benign and secondary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1995: 58: 31-37.
23. COMI G, FILIPPI M, MARTINELLI V, et al. Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J Neurol Sci 1995: 132: 222-227.
24. FILIPPI M, HORSFIELD MA, TOFTS PS, BARKHOF F, THOMPSON AJ, MILLER DH. Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis. Brain 1995: 118: 1601-1612.
25. GRIMAUD J, LAI M, THORPE JW, et al. Evaluation of computer-assisted quantification of MS lesions in cranial MR imaging (abstract). Proceedings of the Society of Magnetic Resonance 1995: 1: 283.
26. MCDONALD WI and HALLIDAY AM. Diagnosis and classification of multiple sclerosis. Br Med Bull 1977: 33: 4-9.
27. KURTZKE JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983: 33: 1444-1452.
28. MILLER DH, BARKHOF F, BERRY I, et al. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis: Concerted Action Guidelines. J Neurol Neurosurg Psychiatry 1991: 54: 683-688.
29. The IFNB Multiple Sclerosis Study Group, the University of British Columbia MS/MRI Analysis Group. Interferon beta-1b in the treatment of multiple sclerosis: final outcome of the randomized controlled trial. Neurology 1995: 45: 1277-1285.
30. FILIPPI M, HORSFIELD MA, CAMPI A, MAMMI S, PEREIRA C, COMI G. Resolution-dependent estimates of lesion volumes in magnetic resonance imaging studies of the brain in multiple sclerosis. Ann Neurol 1995: 38: 749-754.
31. DOUSSET V, GROSSMAN R, RAMER KN, et al. Experimental Allergic Encephalomyelitis and Multiple Sclerosis: Lesion characterization with Magnetization Transfer Imaging. Radiology 1992: 182(2): 483-491.
32. BARBOSA S, BLUMHARDT LD, ROBERTS N, LOCK T, EDWARDS RTH. Magnetic resonance relaxation time mapping in multiple sclerosis: normal appearing white matter and the 'invisible' lesion load. Magn Reson Imaging 1994: 12: 33-42.
33. FILIPPI M, HORSFIELD MA, MORRISSEY SP, et al. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of MS. Neurology 1994: 44: 635-641.
34. LOEVENER LA, GROSSMAN RI, COHEN JA, LEXA FJ, KESSLER D, KOLSON DL. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. Radiology 1995: 96: 511-515.
35. Kidd D, Thorpe JW, Thompson AJ, et al. Spinal cord MRI using multi-array coils and fast spin echo. II. Findings in multiple sclerosis. Neurology 1993: 43: 2632-2637.