A retroviral element in the human CYP2D gene cluster [1]

Pharmacogenetics

Volumn 6, Issue 4, 1996, Pages 375-377

  Molven, Anders ^a   Steen, Vidar M ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

CYP2D6; CYP2D7; Endogenous retrovirus; LTR

Indexed keywords

CYTOCHROME P450 ISOENZYME;

GENE CLUSTER; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; LETTER; LONG TERMINAL REPEAT; PRIORITY JOURNAL; RETROVIRUS;

UNIDENTIFIED RETROVIRUS;

EID: 0029736669     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-199608000-00013     Document Type: Letter

References (8)

1. Daly AK, Steen VM. Fairbrother KS, Idle JR. CYP2D6 multiallelism. Methods Enzymol 1996 (in press).
2. Di Cristofano A, Strazzullo M, Longo L, La Mantia G, Characterization and genomic mapping of the ZNF80 locus: expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family. Nucl Acids Res 1995: 23, 2823-2830.
3. Heim MH, Meyer UA. Evolution of a highly polymorphic human cytochrome P450 gene cluster: CYP2D6. Genomics 1992: 14, 49-58.
4. La Mantia G, Maglione D, Pengue G, Di Cristofano A, Simeone A, Lanfrancone L, Lania L. Identification and characterization of novel human endogenous retroviral sequences preferentially expressed in undifferentiated embryonal carcinoma cells. Nucl Acids Res 1991: 19, 1513-1520.
5. Lania L, Di Cristofano A, Strazzullo M, Pengue G, Majello B, La Mantia G. Structural and functional organization of the human endogenous retroviral ERV9 sequences. Virology 1992: 191, 464-468.
6. Mager DL, Goodchild NL. Homologous recombination between the LTRs of a human retrovirus-like element causes a 5-kb deletion in two siblings. Am J Hum Genet 1989: 45, 848-854.
7. Steen VM, Andreassen OA, Daly AK, Tefre T, Børresen A-L, Idle JR, Gulbrandsen A-K. Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology. Pharmacogenetics 1995a: 5, 215-223.
8. Steen VM, Molven A, Aarskog NK, Gulbrandsen A-K. Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of the human cytochrome P450 CVP2D6 gene. Hum Mol Genet 1995b: 4, 2251-2257.