Phospholipid metabolism induced by Clostridium perfringens alpha-toxin elicits a hot-cold type of hemolysis in rabbit erythrocytes

Infection and Immunity

Volumn 64, Issue 9, 1996, Pages 3930-3933

  Ochi, Sadayuki ^a   Hashimoto, Katsushi ^a   Nagahama, Masahiro ^a   Sakurai, Jun ^a  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CLOSTRIDIUM TOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHOLIPID;

ANIMAL CELL; ARTICLE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; GAS GANGRENE; HEMOLYSATE; HEMOLYSIS; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RABBIT;

EID: 0029736389     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.64.9.3930-3933.1996     Document Type: Article

References (16)

1. Agwu, D. E., L. C. McPhail, M. C. Chabot, L. W. Daniel, R. L. Wykle, and C. E. McCall. 1989. Choline-linked phosphoglycerides: a source of phosphatidic acid and diglycerides in stimulated neutrophils. J. Biol. Chem. 264: 1405-1413.
2. Bhamidipati, S. P., and J. A. Hamilton. 1993. NMR studies of phospholipase C hydrolysis of phosphatidylcholine in model membranes. J. Biol. Chem. 268:2431-2434.
3. Black, W. J., J. J. Munoz, M. G. Peacock, P. A. Schad, J. L. Cowell, J. J. Burchall, M. Lim, A. Kent, L. Steinman, and S. Falkow. 1988. ADP-ribosyl-transferase activity of pertussis toxin and immunomodulation by Bordetella pertussis. Science 240:656-659.
4. Exton, J. H. 1994. Phosphatidylcholine breakdown and signal transduction. Biochim. Biophys. Acta 1212:26-42.
5. Fujii, Y., S. Nomura, Y. Oshila, and J. Sakurai. 1986. Excitatory effect of Clostridium perfringens alpha toxin on the rat isolated aorta. Br. J. Pharmacol. 88:531-539.
6. Fujii, Y., and J. Sakurai. 1989. Contraction of the rat isolated aorta caused by Clostridium perfringens alpha toxin (phospholipase C): evidence for the involvement of arachidonic acid metabolism. Br. J. Pharmacol. 97:119-124.
7. Levine, L., D. M. Xiao, and C. Little. 1988. Increased arachidonic acid metabolites from cells in culture after treatment with the phosphatidylcholine-hydrolyzing phospholipase C from Bacillus cereus. Prostaglandins 34: 633-642.
8. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
9. Meyers, D. J., and R. S. Berk. 1990. Characterization of phospholipase C from Pseudomonas aeruginosa as a potent inflammatory agent. Infect. Immun. 58:659-666.
10. Nagahama, M., K. Michiue, and J. Sakurai. 1996. Membrane-damaging action of Clostridium perfringens alpha-toxin on phospholipid liposomes. Biochim. Biophys. Acta 1280:120-126.
11. Nagahama, M., Y. Okagawa, T. Nakayama, E. Nishioka, and J. Sakurai. 1995. Site-directed mutagenesis of histidine residues in Clostridium perfringens alpha-toxin. J. Bacteriol. 177:1179-1185.
12. Olson, S. C., E. P. Bowman, and J. D. Lambeth. 1991. Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate): activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol. J. Biol. Chem. 266:17236-17242.
13. Sakurai, J. 1995. Toxins of Clostridium perfringens. Rev. Med. Microbiol. 6:175-185.
14. Sakurai, J., V. Fujii, and M. Shirolani. 1990. Contraction induced by Closiridium perfringens alpha toxin in the isolated rat ileum. Toxicon 28:411-418.
15. Sakurai, J., S. Ochi, and H. Tanaka. 1993. Evidence for coupling of ClosIridium perfringens alpha-toxin-induced hemolysis to stimulated phosphatidic acid formation in rabbit erythrocytes. Infect. Immun. 61:3711-3718.
16. Sakurai, J., S. Ochi, and H. Tanaka. 1994. Regulation of Clostridium perfringens alpha-toxin-activated phospholipase C in rabbit erythrocyte membranes. Infect. Immun. 62:717-721.