Evaluation of multidrug resistance phenotype in acute leukemia by determination of nuclear efflux of tetrahydropyranyl-doxorucibin using confocal laser microspectrofluorometry;EVALUATION DU PHENOTYPE DE LA RESISTANCE PLEIOTROPIQUE SUR DES PRELEVEMENTS MEDULLAIRES DE PATIENTS PRESENTANT UNE LEUCEMIE AIGUE PAR MESURE DE L'EFFLUX NUCLEAIRE DE LA TETRAHYDROPYRANYL-DOXORUBICINE. APPROCHE PAR MICROSPECTROFLUORIMETRIE CONFOCALE LASER

Annales de Biologie Clinique

Volumn 54, Issue 1, 1996, Pages 9-15

  Morjani, H ^a   Pignon, B ^b   Vilque, J P ^b   Millot, J M ^a   Lartigue, B ^b   Simon, G ^b   Etienne J C ^b   Potron, G ^b   Manfait, M ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b SERVICE DE DERMATOLOGIE   (France)

Author keywords

Acute leukemia; Anthracycline; Antibiotics; Confocal microscopy; Multidrug resistance; P glycoprotein

Indexed keywords

ANTHRACYCLINE; CD34 ANTIGEN; GLYCOPROTEIN P; PIRARUBICIN; ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; DRUG DERIVATIVE;

ACUTE LEUKEMIA; ARTICLE; BLAST CELL; CELL FRACTIONATION; CELL LEVEL; CELL NUCLEUS; CELL SUSPENSION; CLINICAL ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DNA BINDING; DRUG TRANSPORT; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MICROFLUOROMETRY; MULTIDRUG RESISTANCE; PHENOTYPE; PROTEIN EXPRESSION; ACUTE DISEASE; ACUTE LYMPHOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; BONE MARROW; CHILD; CONFOCAL MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METHODOLOGY; MICROSPECTROPHOTOMETRY; MIDDLE AGED; MYELOID LEUKEMIA; PATHOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBIOTICS, ANTINEOPLASTIC; ANTIGENS, CD34; BIOLOGICAL TRANSPORT; BONE MARROW; CELL NUCLEUS; CHILD; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LEUKEMIA, MYELOID; MICROSCOPY, CONFOCAL; MICROSPECTROPHOTOMETRY; MIDDLE AGED; P-GLYCOPROTEIN; PHENOTYPE;

EID: 0029704406     PISSN: 00033898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Juliano RL, Ling V (1976) A surface P-glycoprotein drug modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455, 152-162
2. Cordon-Cardo C (1991) Immunohistochemical analysis of P-glycoprotein expression in normal and tumor tissues in humans. In. Molecular and cellular biology of multidrug resistance in tumor cells (Roninson IB, ed). Plenum Press, New York, 303-318
3. Bellamy WT, Dalton WS (1994) Multidrug resistance in the laboratory and clinic. In: Advances in clinical chemistry (Spiegel HE, ed). Academic Press Inc, San Diego, vol 31, 1-61
4. Campos L, Guyota TD, Archimbaud E et al (1992) Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis. Blood 79, 473-476
5. Campos L, Guyota TD, Jaffar C et al (1992) Correlation of mdr1/P-170 expression with daunorubicine uptake and sensitivity of leukemic progenitors in acute myeloid leukemia. Eur J Haematol 48, 254-258
6. Marie JP, Zittoun R, Sikic BI (1991) Multidrug resistance (mdr1) gene expression in adult acute leukemias. correlations with treatment outcome and in vitro drug sensitivity. Blood 78, 586-592
7. Merlin JL, Guerci A, Marchal S, Missoum N, Ramacci C, Humbert JC, Tsuruo T, Guerci O (1994) Comparative evaluation of S9788, verapamil and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematological malignancies. Blood 84, 262-269
8. Guerci A, Merlin JL, Missoum N, Feldman L, Marchal S, Witz F, Rose C, Guerci O (1995) Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation and P-glycoprotein expression simultaneously determined by flow cytometry. Blood 85, 2147-2153
9. Pignon B, Morjani H, Vilque JP, Millot JM, Lartigue B, Simon G, Étienne JC, Potron G, Manfait M (1995) In vitro study of THP-doxorubicin retention in human leukemic cells using confocal laser microspectrofluorometry. Leukemia (à paraître)
10. Kokenberg E, Sonneveld P, Delwel R et al (1988) In vivo uptake of daunorubicin by acute myeloid leukemia (AML) cells measured by flow cytometry. Leukemia 8, 511-517.
11. Speth P, Linssen P, Boezeman J, Wessels H, Haanen C (1985) Quantitation of anthracyclines in human hematopoietic cell subpopulations by flow cytometry correlated with high pressure liquid chromatography. Cytometry 6, 143-150
12. Gewirtz DA, Yanowitch S (1987) Metabolism of adriamycin in hepatocytes isolated from the rat and the rabbit. Biochem Pharmacol 36, 1793-1798
13. Geller RB, Zarurak M, Hurwitz CA et al (1990) Prognostic importance of immunophenotyping in adults with acute myelocytic leukemia: the significance of the stem-cell glycoprotein CD34 (My 10). Br J Haematol 76, 340-347
14. Millot JM, Rasoanaivo T, Angiboust JF, Gigli M, Manfait M (1989) Microspectrofluorimétrie sur cellules vivantes : incorporation nucléaire et pharmacocinétique. Innov Tech Biol Med 10, 160-174
15. Gigli M, Doglia SM, Millot JM, Valentini L, Manfait M (1988) Quantitative study of doxorubicin in living cell nuclei by microspectrofluorometry. Biochim Biophys Acta 950, 13-20
16. Morjani H, Pignon B, Millot JM, Debal V, Lamiable D, Potron G, Etienne JC, Manfait M (1992) Intranuclear concentration measurements of doxorubicin in living leucocytes from patients treated for lympho-proliferative disorder. Leukemia Res 16, 647-653
17. Debal V, Allam N, Morjani H, Millot JM, Braguer D, Breillout, Manfait M (1994) Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids. Br J Cancer 70, 1118-1125
18. Millot JM, Pingret L, Angiboust JF, Bonhomme A, Pinon JM, Manfait M (1995) Quantitative determination of free calcium in subcellular compartments, as probed by Indo-1 and confocal microspectrofluorometry. Cell Calcium 17, 354-366
19. Musto P, Melillo L, Lombardi G et al (1991) High risk of early resistant relapse for leukemic patients with presence of multidrug resistance associated P-glycoprotein positive cells in complete remission. Br J Haematol 77, 50-53
20. Pirker R, Wallner J, Geissler K et al (1991) mdr1 gene expression and treatment outcome in acute myeloid leukemia. J Natl Cancer Inst 83, 708-712
21. Sato H, Gottesman MM, Goldstein LJ, Pastan I, Block AM, Sandberg AA, Preisler HD (1990) Expression of the multidrug resistance gene in myeloid leukemias. Leuk Res 14, 11-21
22. Michteli M, Damiani D, Geromin A et al (1992) Overexpression of multidrug resistance-associated P-170 glycoprotein in acute non-lymphocytic leukemia. Eur J Haematol 48, 87-92
23. Zhou DC, Mane JP, Suberville AM, Zittoun R (1992) Rlevance of mdr1 gene expression in acute myeloid leukemia and comparison of different diagnostic methods. Leukemia 6, 879-885
24. Chaudhary PM, Roninson IB (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human, hematopoietic stem cells. Cell 66, 85-87
25. List AF, Spier CM, Cline A et al (1991) Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with stem cell phenotype. Br J Haematol 78, 28-32