Acute cardiotoxicity of moniliformin in broiler chickens as measured by electrocardiography

Avian Diseases

Volumn 40, Issue 1, 1996, Pages 223-227

  Nagaraj, R Y ^a   Wu, W ^a   Will, J A ^a   Vesonder, R F ^b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b NATIONAL CENTER FOR AGRICULTURAL UTILIZATION RESEARCH   (United States)

Author keywords

Bradycardia; Broilers; Electrocardiogram; Moniliformin; Mycotoxin

Indexed keywords

AVES; GALLUS GALLUS;

CYCLOBUTANE DERIVATIVE; MONILIFORMIN; MYCOTOXIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRD DISEASE; BRADYCARDIA; CHEMICALLY INDUCED DISORDER; CHICKEN; DRUG EFFECT; ELECTROCARDIOGRAPHY; HEART RATE; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ANIMALS; BRADYCARDIA; CHICKENS; CYCLOBUTANES; ELECTROCARDIOGRAPHY; HEART RATE; MYCOTOXINS; POULTRY DISEASES; TIME FACTORS;

EID: 0029692659     PISSN: 00052086     EISSN: None     Source Type: Journal    
DOI: 10.2307/1592393     Document Type: Article

References (24)

1. Allen, N. K., H. R. Burmeister, G. A. Weaver, and C. J. Mirocha. Toxicity of dietary and intravenously administered moniliformin to broiler chickens. Poult. Sci. 60:1415-1417. 1981.
2. Angus, J. A., R. M. Brazenor, and M. Leduc. Effects of verapamil on coronary artery diameter, car-diac contractility, and P-R interval. Clin. Exp. Pharmacol. Physiol. 6:15-28. 1982.
3. Antoni, H. Pathophysiology of cardiac arrhythmias (review). Z. Kardiol. 81:111-117. 1992.
4. Bhandari, A. K., and P. T. Sager. Management of periinfarctional ventricular arrhythmias and conduction disturbances. In: Cardiac arrhythmias: a practical approach, vol. 2. G. V. Naccarelli, ed. Furura Publishing Co., Inc., New York. pp. 283-324. 1991.
5. Burmeister, H. R., A. Ciegler, and R. F. Vesonder. Moniliformin a metabolite of Fusarium moniliforme NRRL 6322: purification and toxicity. Appl. Environ. Microbiol. 39:957-961. 1979.
6. Cole, R. J., and R. H. Cox. Handbook of toxic fungal metabolites. Academic Press, New York. pp. 894-897. 1981.
7. Cole, R. J., J. W. Kirksey, H. G. Cutler, B. L. Doupnik, and J. C. Peckham. Toxin from Fusarium moniliforme: effects on plants and animals. Science 179:1324-1326. 1973.
8. + current in rat ventricular myocytes. Am. J. Physiol. 257:H1746-H1749. 1989.
9. Engelhardt, J. A., W. W. Carlton, and J. F. Tuite. Toxicity of Fusarium moniliforme var. subglutinans for chicks, ducklings and turkey poults. Avian Dis. 52:1523-1530. 1989.
10. Gathercole, P. S., P. G. Thiel, and J. H. S. Hofmeyr. Inhibition of pyruvate dehydrogenase complex by moniliformin. Biochem. J. 233:719-723. 1986.
11. Gelderblom, W. C. A., P. G. Thiel, W. F. O. Marasas, and K. J. Van der Merwe. Natural occurrence of rusarin C, a mutagen produced by Fusarium moniliforme in corn. J. Agric. Food Chem. 32:1064-1067. 1984.
12. James, T. N. The coronary circulation and conduction system in acute myocardial infarction. Prog. Cardiovasc. Dis. 10:410-449. 1968.
13. Kriek, N. P. J., W. F. O. Marasas, P. S. Steyn, S. J. Van Rensberg, and M. Steyn. Toxicity of a moniliformin-producing strain of Fusarium moniliforme var. subglutinans isolated from maize. Food Cosmet. Toxicol. 15:579-587. 1977.
14. Marasas, W. F. O., P. G. Thiel, C. J. Rabie, P. E. Nelson, and T. A. Toussoun. Moniliformin production in Fusarium section Liseola. Mycologia 78: 242-247. 1986.
15. Morgan, W. Effective anesthesia for chick surgery. Proc. S.D. Acad. Sci. 36:105-108. 1957.
16. Nagaraj, R. Y., W. D. Wu, and R. F. Vesonder. Toxicity of corn culture material of Fusarium proliferatum M-7176 and nutritional intervention in chicks. Poult. Sci. 73:617-626. 1994.
17. Paletta, M., S. Abraham, G. N. Beatch, and M. J. A. Walker. Mechanisms underlying the antiarrhythmic properties of beta adrenoceptor blockade against ischemia-induced arrhythmias in acutely prepared rats. Br. J. Pharmacol. 98:87-94. 1989.
18. SAS Institute. SAS user's guide: statistics, version 5 ed. SAS Institute Inc., Cary, N.C. 1985.
19. Spedding, M. Differences between the effects of calcium antagonist in the pithed rat preparation. Cardiovasc. Pharmacol. 4:973-979. 1982.
20. Sutherland, D. J. B., A. W. Jaussi, and C. J. Gubler. The effect of thiamine deprivation, and oxythiamine- and pyrithiamine-treatment on cardiac function and metabolism in the rat. J. Nutr. Sci. Vitaminol. 20:35-54. 1974.
21. Thiel, P. G. A molecular mechanism for the toxic action of moniliformin, a mycotoxin produced by Fusarium moniliforme. Biochem. Pharmacol. 27: 483-486. 1978.
22. Thiel, P. G., C. J. Meyer, and W. F. O. Marasas. Natural occurrence of moniliformin together with deoxynivalenol and zearalenone in Transkeian corn. J. Agric. Food Chem. 30:308-312. 1982.
23. Vaughan-Williams, E. M. Subgroups of class 1 antiarrhythmic drugs. Eur. Heart J. 5:96-98. 1984.
24. Zhao, D., F. Q. Feng, X. Yan, C. Li, Y. Pan, and Q. Cui. Ultrastructural study of moniliformin induced lesions of myocardium in rats and mice. Biomed. Environ. Sci. 6:37-44. 1993.