Regional chemotherapy for colorectal hepatic metastases: Evidence for improved survival with new drug combinations

Annals of Surgical Oncology

Volumn 3, Issue 1, 1996, Pages 36-43

  Sutanto Ward, E ^a   Arisawa, Y ^a   Tremiterra, S ^a   Sigurdson, E R ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

5 Fluorouridine; Colorectal cancer; FUdR; Hepatic arterial infusion; Hepatic metastases; Mitomycin C

Indexed keywords

ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIBIOTIC; ANTINEOPLASTIC ANTIMETABOLITE; FLOXURIDINE; MITOMYCIN;

ANIMAL; ARTICLE; CELL CULTURE; COLORECTAL TUMOR; INTRAARTERIAL DRUG ADMINISTRATION; LIVER TUMOR; MALE; METASTASIS; PATHOLOGY; RAT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; FLOXURIDINE; INFUSIONS, INTRA-ARTERIAL; INJECTIONS, INTRA-ARTERIAL; LIVER NEOPLASMS; MALE; MITOMYCIN; RATS; TUMOR CELLS, CULTURED;

EID: 0029690793     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02409049     Document Type: Article

References (23)

1. Coller FA. In: Ransom HK, Regan WJ, eds. Cancer of the colon and rectum. New York: American Cancer Society, 1956:3-4.
2. Chen HSG, Gross JF. Intra-arterial infusion of anti-cancer drugs: theoretic aspects of drug delivery and review of responses. Cancer Treat Rep 1980;64:31-40.
3. Breedis C, Young C. The blood supply of neoplasms in the liver. Am J Pathol 1954;30:969.
4. Cohen A, Schaeffer N, Higgins J. Treatment of metastatic colorectal cancer with hepatic artery combination chemotherapy. Cancer 1986;57:1115-7.
5. Sigurdson ER, Ridge JA, Kemeny N, Daly JM. Tumor and liver drug uptake following hepatic artery and portal vein infusion. J clin Oncol 1987;5:1936-40.
6. Kemeny N. Is hepatic infusion of chemotherapy effective for liver metastases? Yes! In: DeVita VT, Hellman S, Rosenberg S, eds. Important advances in oncology. Philadelphia: JB Lippincott, 1992:207-27.
7. Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P. Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann Intern Med 1987;107:459-65.
8. Martin MS, Martin F, Michiels R, et at. An experimental model for cancer of the colon and rectum. Digestion 1973; 8:22-34.
9. House AK, Maley MAL. Clinical and in vivo response following surgery or surgery plus adjuvant chemotherapy or immunotherapy for colorectal carcinoma in a rat model. J R Soc Med 1983;76:833-16.
10. Martin F, Caignard A, Jeannin JF, Leclerc A, Martin M. Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors. Int J Cancer 1983; 32:623-7.
11. Marquet RL, Westbroek DL, Jeekel J. Interferon treatment of a transplantable rat colon adenocarcinoma: importance of tumor site. Int J Cancer 1984;33:689-92.
12. Suto A, Kubota T, Shimoyama Y, Ishibiki K, Abe O. MTT assay with reference to the clinical effect of chemotherapy. J Surg Oncol 1989;42:28-32.
13. van der Elst J, De Greve J, Geerts F, De Neve W, Storme G, Willems G. Quantitative study of liver metastases from colon cancer in rats after treatment with cyclosporin A. J Natl Cancer Inst 1986;77:227-31.
14. van Dale P, Galand P. Effect of partial hepatectomy on experimental liver invasion by intraportally injected colon carcinoma cells in rats. Invasion Metastasis 1988;8:217-27.
15. Archer SG, Gray BN. Comparison of portal vein chemother-apy with hepatic artery chemotherapy in the treatment of liver micrometastases. Am J Surg 1990;159:325-9.
16. Kemeny N, Conti J, Sigurdson E, et al. A pilot study of hepatic artery floxuridine combined with systemic 5-fluorouracil and leucovorin. Cancer 1993;71:1964-71.
17. Wilkinson DS, Pilot HC. Inhibition of ribosomal ribonucleic acid maturation in Novikoff hepatoma cells by 5-fluorouracil and 5-fluorouridine. J Biol Chem 1973;248:63-8.
18. Wilkinson DS, Tisty TD, Hanas RJ. The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine. Cancer Res 1975;35:3014-20.
19. Currie VE, Burchenal JH, Sykes MP, Clarkson BD, Krakoff IH. Animal and clinical studies of 5-fluorouridine. Proc AACR ASCO 1975;16:188.
20. Anukarahanonta T, Holstege A, Keppler D. Selective enhancement of 5-fluorouridine uptake and action in rat hepatomas in vivo following pretreatment with D-galactosamine and 6-azauridine or N-(phosphonacetyl)-L-aspartate. Eur J Cancer 1980;16:1171-80.
21. Pausch J, Holstege A, Anukarahanonta T, Keppler D, Gerok W. First clinical experiences with a selective chemotherapy of hepatocellular carcinoma with 5-fluorouridine in combination with other antipyrimidines. Adv Enzyme Regul 1985; 24:429-32.
22. Kemeny N, Cohen A, Seiter K, Conti J, Sigurdson E. Randomized trial of hepatic arterial floxuridine, mitomycin, and carmustine versus floxuridine alone in previously treated patients with liver metastases from colorectal cancer. J clin Oncol 1993;11:330-5.
23. Atiq O, Kemeny N, Niedzweiki D, Botet J. Treatment of unresectable primary liver cancer with intrahepatic fluorodeoxyuridine and mitimycin C through an implantable pump. Cancer 1992;69:920-24.