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Volumn 27, Issue SUPPL. 1, 1996, Pages 35-40

Colorectal cancer: Molecular genetic studies and their future clinical applications

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; COLON CARCINOGENESIS; COLORECTAL CANCER; CONFERENCE PAPER; DNA DAMAGE; DNA REPAIR; FAMILIAL CANCER; GENE MUTATION; HUMAN; MOLECULAR GENETICS; ONCOGENE; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; COLON TUMOR; DISEASE COURSE; FORECASTING; GENETICS; MOLECULAR BIOLOGY; MUTATION; RECTUM TUMOR; REVIEW;

EID: 0029690587     PISSN: 00981532     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-911X(1996)27:1+<35::AID-MPO7>3.0.CO;2-O     Document Type: Conference Paper
Times cited : (7)

References (57)
  • 1
    • 0026010995 scopus 로고
    • Molecular themes in oncogenesis
    • Bishop JM: Molecular themes in oncogenesis. Cell 64:235, 1991.
    • (1991) Cell , vol.64 , pp. 235
    • Bishop, J.M.1
  • 2
    • 0026074818 scopus 로고
    • Cooperation between oncogenes
    • Hunter T. Cooperation between oncogenes. Cell 64:249, 1991.
    • (1991) Cell , vol.64 , pp. 249
    • Hunter, T.1
  • 3
    • 0026069474 scopus 로고
    • Oncogenes and signal transduction
    • Cantley LC, Auger KR, Carpenter C, et al: Oncogenes and signal transduction. Cell 64:281, 1991.
    • (1991) Cell , vol.64 , pp. 281
    • Cantley, L.C.1    Auger, K.R.2    Carpenter, C.3
  • 4
    • 0028362724 scopus 로고
    • Oncogenes and tumor suppressor genes
    • Weinberg R: Oncogenes and tumor suppressor genes. CA Cancer J Clin 44:160, 1994.
    • (1994) CA Cancer J Clin , vol.44 , pp. 160
    • Weinberg, R.1
  • 5
    • 0026059515 scopus 로고
    • Tumor suppressor genes
    • Marshall CJ: Tumor suppressor genes. Cell 64:213, 1991.
    • (1991) Cell , vol.64 , pp. 213
    • Marshall, C.J.1
  • 6
    • 0027504088 scopus 로고
    • Antioncogenes and human cancer
    • Knudson AG: Antioncogenes and human cancer. Proc Natl Acad Sci USA 90:10914, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10914
    • Knudson, A.G.1
  • 7
    • 0027977269 scopus 로고
    • It was a very good year for DNA repair
    • Cleaver JE: It was a very good year for DNA repair. Cell 76:1, 1994.
    • (1994) Cell , vol.76 , pp. 1
    • Cleaver, J.E.1
  • 8
    • 0027742295 scopus 로고
    • The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancers
    • Fishel R, Lescoe MK, Rao MRS, et al: The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancers. Cell 75:1027, 1993.
    • (1993) Cell , vol.75 , pp. 1027
    • Fishel, R.1    Lescoe, M.K.2    Rao, M.R.S.3
  • 9
    • 0027145633 scopus 로고
    • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
    • Leach FS, Nicolaides NC, Papdopoulos N, et al: Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215, 1993.
    • (1993) Cell , vol.75 , pp. 1215
    • Leach, F.S.1    Nicolaides, N.C.2    Papdopoulos, N.3
  • 10
    • 0028221943 scopus 로고
    • Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
    • Bronner CE, Baker SM, Morrison PT, et al: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368:258, 1994.
    • (1994) Nature , vol.368 , pp. 258
    • Bronner, C.E.1    Baker, S.M.2    Morrison, P.T.3
  • 11
    • 0028350601 scopus 로고
    • Mutation of a mutL homolog in hereditary colon cancer
    • Papadopoulos N, Nicolaides NC, Wei Y-F, et al: Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625, 1994.
    • (1994) Science , vol.263 , pp. 1625
    • Papadopoulos, N.1    Nicolaides, N.C.2    Wei, Y.-F.3
  • 12
    • 0028106776 scopus 로고
    • HMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds
    • Liu B, Parsons RE, Hamilton SR, et al: hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds. Cancer Res 54:4590, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4590
    • Liu, B.1    Parsons, R.E.2    Hamilton, S.R.3
  • 13
    • 0024268176 scopus 로고
    • The adenomatous polyp and the hereditary polyposis syndromes
    • Burt RW, Samowitz WS: The adenomatous polyp and the hereditary polyposis syndromes. Gastroenterol Clin North Am 17:657, 1988.
    • (1988) Gastroenterol Clin North Am , vol.17 , pp. 657
    • Burt, R.W.1    Samowitz, W.S.2
  • 14
    • 0022810104 scopus 로고
    • Brief clinical report: Gardner syndrome in a man with interstitial deletion of 5q
    • Herrera L, Kakati S, Gibas L, et al: Brief clinical report: Gardner syndrome in a man with interstitial deletion of 5q. Am J Med Genet 25:473, 1986.
    • (1986) Am J Med Genet , vol.25 , pp. 473
    • Herrera, L.1    Kakati, S.2    Gibas, L.3
  • 15
    • 0023223410 scopus 로고
    • Localization of the gene for familial polyposis on chromosome 5
    • Bodmer WF, Bailey C, Bodmer J, et al: Localization of the gene for familial polyposis on chromosome 5. Nature 328:614, 1987.
    • (1987) Nature , vol.328 , pp. 614
    • Bodmer, W.F.1    Bailey, C.2    Bodmer, J.3
  • 16
    • 0023572211 scopus 로고
    • The gene for familial polyposis coli maps to the long arm of chromosome 5
    • Leppert M, Dobbs M, Scambler P, et al: The gene for familial polyposis coli maps to the long arm of chromosome 5. Science 238:1411, 1987.
    • (1987) Science , vol.238 , pp. 1411
    • Leppert, M.1    Dobbs, M.2    Scambler, P.3
  • 17
    • 0025938038 scopus 로고
    • Identification and characterization of the familial adenomatous polyposis coli gene
    • Groden J, Thlivers A, Samowitz W, et al: Identification and characterization of the familial adenomatous polyposis coli gene. Cell 66:589, 1991.
    • (1991) Cell , vol.66 , pp. 589
    • Groden, J.1    Thlivers, A.2    Samowitz, W.3
  • 18
    • 0025941471 scopus 로고
    • Identification of deletion mutations and three new genes at the familial polyposis locus
    • Joslyn G, Carlson M, Thlivers A, et al: Identification of deletion mutations and three new genes at the familial polyposis locus. Cell 66:601, 1991.
    • (1991) Cell , vol.66 , pp. 601
    • Joslyn, G.1    Carlson, M.2    Thlivers, A.3
  • 19
    • 0025817880 scopus 로고
    • Identification of FAP locus genes from chromosome 5q21
    • Kinzler KW, Nilbert MC, Su L-K, et al: Identification of FAP locus genes from chromosome 5q21. Science 253:661, 1991.
    • (1991) Science , vol.253 , pp. 661
    • Kinzler, K.W.1    Nilbert, M.C.2    Su, L.-K.3
  • 20
    • 0025899162 scopus 로고
    • Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
    • Nishisho I, Nakamura Y, Miyoshi Y, et al: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253:665, 1991.
    • (1991) Science , vol.253 , pp. 665
    • Nishisho, I.1    Nakamura, Y.2    Miyoshi, Y.3
  • 21
    • 0027763498 scopus 로고
    • Molecular diagnosis of familial adenomatous polyposis
    • Powell SM, Petersen GM, Krush AJ, et al: Molecular diagnosis of familial adenomatous polyposis. N Engl J Med 329:1982, 1993.
    • (1993) N Engl J Med , vol.329 , pp. 1982
    • Powell, S.M.1    Petersen, G.M.2    Krush, A.J.3
  • 22
    • 0027724691 scopus 로고
    • Alleles of the APC gene: An attenuated form of familial polyposis
    • Spirio L, Olschwang S, Groden J, et al: Alleles of the APC gene: an attenuated form of familial polyposis. Cell 75:951, 1993.
    • (1993) Cell , vol.75 , pp. 951
    • Spirio, L.1    Olschwang, S.2    Groden, J.3
  • 23
    • 0026630266 scopus 로고
    • APC mutations occur early during colorectal tumorigenesis
    • Powell WM, Zilz N, Beazer-Barclay Y, et al: APC mutations occur early during colorectal tumorigenesis. Nature 359:235, 1992.
    • (1992) Nature , vol.359 , pp. 235
    • Powell, W.M.1    Zilz, N.2    Beazer-Barclay, Y.3
  • 24
    • 0026894053 scopus 로고
    • Somatic mutations of the APC gene in colorectal tumors: Mutations cluster region in the APC gene
    • Miyoshi Y, Nagase H, Ando H, et al: Somatic mutations of the APC gene in colorectal tumors: mutations cluster region in the APC gene. Hum Mol Genet 1:229, 1992.
    • (1992) Hum Mol Genet , vol.1 , pp. 229
    • Miyoshi, Y.1    Nagase, H.2    Ando, H.3
  • 25
    • 9344263008 scopus 로고
    • Inactivation of both APC gene products with b-catenin
    • Levy DB, Smith KJ, Beazer-Barclay Y, et al: Inactivation of both APC gene products with b-catenin. Science 253:665, 1993.
    • (1993) Science , vol.253 , pp. 665
    • Levy, D.B.1    Smith, K.J.2    Beazer-Barclay, Y.3
  • 26
    • 9344263008 scopus 로고
    • Association of the APC gene product with b-catenin
    • Rubinfeld B, Souza B, Albert I, et al: Association of the APC gene product with b-catenin. Science 253:665, 1993.
    • (1993) Science , vol.253 , pp. 665
    • Rubinfeld, B.1    Souza, B.2    Albert, I.3
  • 27
    • 0027756014 scopus 로고
    • Association of the APC tumor suppressor protein with catenins
    • Su L-K, Vogelstein B, Kinzler KW. Association of the APC tumor suppressor protein with catenins. Science 262:1734, 1993.
    • (1993) Science , vol.262 , pp. 1734
    • Su, L.-K.1    Vogelstein, B.2    Kinzler, K.W.3
  • 29
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
    • Lynch HT, Smyrk TC, Watson P, et al: Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 104:1535, 1993.
    • (1993) Gastroenterology , vol.104 , pp. 1535
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3
  • 30
    • 0027933070 scopus 로고
    • Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
    • Nicolaides NC, Papadopoulous N, Lin B, et al: Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371:75, 1994.
    • (1994) Nature , vol.371 , pp. 75
    • Nicolaides, N.C.1    Papadopoulous, N.2    Lin, B.3
  • 31
    • 0027158031 scopus 로고
    • Clues to the pathogenesis of familial colorectal cancer
    • Aaltonen LA, Peltomaki P, Leach FS, et al: Clues to the pathogenesis of familial colorectal cancer. Science 260:812, 1993.
    • (1993) Science , vol.260 , pp. 812
    • Aaltonen, L.A.1    Peltomaki, P.2    Leach, F.S.3
  • 32
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260:816, 1993.
    • (1993) Science , vol.260 , pp. 816
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 33
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al: Genetic alterations during colorectal tumor development. N Engl J Med 319:525, 1988.
    • (1988) N Engl J Med , vol.319 , pp. 525
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 34
    • 0025241292 scopus 로고
    • Genetic changes and histopathological types in colorectal tumors from patients with adenomatous polyposis
    • Miyaki M, Seki M, Okamoto M, et al: Genetic changes and histopathological types in colorectal tumors from patients with adenomatous polyposis. Cancer Res 50:7166, 1990.
    • (1990) Cancer Res , vol.50 , pp. 7166
    • Miyaki, M.1    Seki, M.2    Okamoto, M.3
  • 35
    • 0027138093 scopus 로고
    • K-ras mutations in putative preneoplastic lesions in human colon
    • Pretlow TP, Brasitus PA, Fulton NC, et al: K-ras mutations in putative preneoplastic lesions in human colon. J Natl Cancer Inst 85:2004, 1993.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 2004
    • Pretlow, T.P.1    Brasitus, P.A.2    Fulton, N.C.3
  • 36
    • 0027973077 scopus 로고
    • Molecular determinants of dysplasia in colorectal lesions
    • Jen J, Powell SM, Papadopoulos N, et al: Molecular determinants of dysplasia in colorectal lesions. Cancer Res 54:5523, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5523
    • Jen, J.1    Powell, S.M.2    Papadopoulos, N.3
  • 37
    • 0027136679 scopus 로고
    • K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer
    • Fearon ER. K-ras gene mutation as a pathogenetic and diagnostic marker in human cancer. J Natl Cancer Inst 85:1978, 1993.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1978
    • Fearon, E.R.1
  • 38
    • 0027905014 scopus 로고
    • Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Shirasawa S, Furuse M, Yokoyama N, et al: Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260:85, 1993.
    • (1993) Science , vol.260 , pp. 85
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3
  • 39
    • 0002112642 scopus 로고
    • Molecular abnormalities in colon and rectal cancer
    • Mendelsohn J, Howley PM, Israel MA, Liotta LA (eds): Philadelphia: WB Saunders Company
    • Fearon ER: Molecular abnormalities in colon and rectal cancer. In Mendelsohn J, Howley PM, Israel MA, Liotta LA (eds): "The Molecular Basis of Cancer." Philadelphia: WB Saunders Company, 1995, pp. 340-357.
    • (1995) The Molecular Basis of Cancer , pp. 340-357
    • Fearon, E.R.1
  • 40
    • 0021879645 scopus 로고
    • Hereditary cancer, oncogenes and anti-oncogenes
    • Knudson AG Jr: Hereditary cancer, oncogenes and anti-oncogenes. Cancer Res 45:1437, 1985.
    • (1985) Cancer Res , vol.45 , pp. 1437
    • Knudson Jr., A.G.1
  • 41
    • 0024514647 scopus 로고
    • Allelotype of colorectal carcinomas
    • Vogelstein B, Fearon ER, Kern SE, et al: Allelotype of colorectal carcinomas. Science 244:207, 1989.
    • (1989) Science , vol.244 , pp. 207
    • Vogelstein, B.1    Fearon, E.R.2    Kern, S.E.3
  • 42
    • 1842324305 scopus 로고
    • Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
    • Baker SJ, Fearon ER, Nigro JM, et al: Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 24:207, 1989.
    • (1989) Science , vol.24 , pp. 207
    • Baker, S.J.1    Fearon, E.R.2    Nigro, J.M.3
  • 43
    • 0025634118 scopus 로고
    • p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM, et al: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717, 1990.
    • (1990) Cancer Res , vol.50 , pp. 7717
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3
  • 44
    • 0028137084 scopus 로고
    • p53: A glimpse at the puppet behind the shadow play
    • Friend SH: p53: a glimpse at the puppet behind the shadow play. Science 265:334, 1994.
    • (1994) Science , vol.265 , pp. 334
    • Friend, S.H.1
  • 45
    • 0000712278 scopus 로고
    • A mammalian cell cycle check-point pathway utilizing p53 and GASS45 is detective in ataxia-telangiectasia
    • Kastan MB, Zhan Q, El-Deiry WS, et al: A mammalian cell cycle check-point pathway utilizing p53 and GASS45 is detective in ataxia-telangiectasia. Cell 71:817, 1993.
    • (1993) Cell , vol.71 , pp. 817
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3
  • 46
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • El-Deiry WS, Tokino T, Velculescu VE, et al: WAF1, a potential mediator of p53 tumor suppression. Cell 75:817, 1993.
    • (1993) Cell , vol.75 , pp. 817
    • El-Deiry, W.S.1    Tokino, T.2    Velculescu, V.E.3
  • 47
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper JW, Adami GR, Wei N, et al: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75:805, 1993.
    • (1993) Cell , vol.75 , pp. 805
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3
  • 48
    • 0027109075 scopus 로고
    • p53, guardian of the genome
    • Lane DP: p53, guardian of the genome. Nature 358:15, 1992.
    • (1992) Nature , vol.358 , pp. 15
    • Lane, D.P.1
  • 49
    • 0028025563 scopus 로고
    • Apoptosis in cancer therapy: Crossing the threshold
    • Fisher DE: Apoptosis in cancer therapy: crossing the threshold. Cell 78:539, 1994.
    • (1994) Cell , vol.78 , pp. 539
    • Fisher, D.E.1
  • 50
    • 0027474820 scopus 로고
    • Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma
    • Ookawa K, Sakamoto M, Hirohashi S, Yoshida Y, Sugimura T, Terada M, Yokota J: Concordant p53 and DCC alterations and allelic losses on chromosomes 13q and 14q associated with liver metastases of colorectal carcinoma. Int J Cancer 53:382, 1993.
    • (1993) Int J Cancer , vol.53 , pp. 382
    • Ookawa, K.1    Sakamoto, M.2    Hirohashi, S.3    Yoshida, Y.4    Sugimura, T.5    Terada, M.6    Yokota, J.7
  • 51
    • 0028321495 scopus 로고
    • Chromosome 18q loss and prognosis of colorectal cancer
    • Jen J, Kim H, Piantodosi S, et al: Chromosome 18q loss and prognosis of colorectal cancer. N Engl J Med 331:213, 1994.
    • (1994) N Engl J Med , vol.331 , pp. 213
    • Jen, J.1    Kim, H.2    Piantodosi, S.3
  • 52
    • 0025056930 scopus 로고
    • Identification of a chromosome 18q gene which is altered in colorectal cancers
    • Fearon ER, Cho KR, Nigro JM, et al: Identification of a chromosome 18q gene which is altered in colorectal cancers. Science 247:49, 1990.
    • (1990) Science , vol.247 , pp. 49
    • Fearon, E.R.1    Cho, K.R.2    Nigro, J.M.3
  • 53
    • 0028314271 scopus 로고
    • The DCC gene - Structural analysis and mutations in colorectal carcinomas
    • Cho KR, Oliner JD, Simons JW, et al: The DCC gene - structural analysis and mutations in colorectal carcinomas. Genomics 19:525, 1994.
    • (1994) Genomics , vol.19 , pp. 525
    • Cho, K.R.1    Oliner, J.D.2    Simons, J.W.3
  • 54
    • 0028228920 scopus 로고
    • The DCC gene product in cellular differentiation and colorectal tumorigenesis
    • Hefrick L, Cho KR, Fearon ER, et al: The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev 8:1174, 1994.
    • (1994) Genes Dev , vol.8 , pp. 1174
    • Hefrick, L.1    Cho, K.R.2    Fearon, E.R.3
  • 55
    • 0027934722 scopus 로고
    • Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues
    • Reale MA, Hu G, Zafar AI, et al: Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res 54:4493, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4493
    • Reale, M.A.1    Hu, G.2    Zafar, A.I.3
  • 56
    • 0026537986 scopus 로고
    • Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors
    • Sidransky D, Tokino T, Hamilton SR, et al: Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors. Science 256:102, 1992.
    • (1992) Science , vol.256 , pp. 102
    • Sidransky, D.1    Tokino, T.2    Hamilton, S.R.3
  • 57
    • 0028331587 scopus 로고
    • Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
    • Gibbs JB, Oliff A, Kohl NE: Farnesyltransferase inhibitors: ras research yields a potential cancer therapeutic. Cell 77:175, 1994.
    • (1994) Cell , vol.77 , pp. 175
    • Gibbs, J.B.1    Oliff, A.2    Kohl, N.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.